يعرض 1 - 10 نتائج من 13 نتيجة بحث عن '"Riccardo Petrelli"', وقت الاستعلام: 0.90s تنقيح النتائج
  1. 1
    Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents

    المؤلفون: Loredana Cappellacci, Mario Grifantini, Filippo Maggi, Riccardo Petrelli, Diego Romano Perinelli

    المصدر: Current Medicinal Chemistry. 27:2449-2493

    مصطلحات موضوعية: Antineoplastic Agents, Apoptosis, Hydroxamic Acids, Biochemistry, Romidepsin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Neoplasms, Panobinostat, Drug Discovery, medicine, Humans, Vorinostat, 030304 developmental biology, Pharmacology, 0303 health sciences, Hydroxamic acid, business.industry, Organic Chemistry, Cancer, Cell Cycle Checkpoints, medicine.disease, Histone Deacetylase Inhibitors, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Molecular Medicine, Histone deacetylase, business, Belinostat, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8ef85e172931dfb2420bcfe9fba24aTest
    https://doi.org/10.2174/0929867325666181016163110Test


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  2. 2
    Exploring the Molecular Mechanisms Underlying the in vitro Anticancer Effects of Multitarget‐Directed Hydrazone Ruthenium(II)–Arene Complexes

    المؤلفون: Massimiliano Cuccioloni, Laura Bonfili, Mauro Angeletti, Riccardo Petrelli, Loredana Cappellacci, Anna Maria Eleuteri, Massimo Nabissi, Fabio Marchetti, Riccardo Pettinari, Valentina Cecarini

    المصدر: ChemMedChem. 15:105-113

    مصطلحات موضوعية: Cell Membrane Permeability, Stereochemistry, media_common.quotation_subject, Serum albumin, Hydrazone, chemistry.chemical_element, Antineoplastic Agents, Apoptosis, 01 natural sciences, Biochemistry, Ruthenium, Cell membrane, chemistry.chemical_compound, Coordination Complexes, Cell Line, Tumor, Drug Discovery, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Internalization, Cytotoxicity, media_common, Pharmacology, chemistry.chemical_classification, Binding Sites, biology, 010405 organic chemistry, Organic Chemistry, Hydrazones, Cell Cycle Checkpoints, DNA, In vitro, 0104 chemical sciences, Molecular Docking Simulation, Kinetics, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, biology.protein, Nucleic Acid Conformation, Molecular Medicine, Hydroxymethylglutaryl CoA Reductases, Cyclin-Dependent Kinase Inhibitor p27, Protein Binding

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6998f8b0f4699db4e3fa2f6f17dbac7aTest
    https://doi.org/10.1002/cmdc.201900551Test


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  3. 3
    Ligand Design for N,O- or N,N-Pyrazolone-Based Hydrazones Ruthenium(II)-Arene Complexes and Investigation of Their Anticancer Activity

    المؤلفون: Fabio Marchetti, Armando J. L. Pombeiro, Riccardo Pettinari, Agustín Galindo, Loredana Cappellacci, Claudio Pettinari, Laura Bonfili, Massimiliano Cuccioloni, M. Fátima C. Guedes da Silva, Riccardo Petrelli, Anna Maria Eleuteri, Corrado Di Nicola

    المصدر: Inorganic Chemistry. 57:14123-14133

    مصطلحات موضوعية: Double bond, Pyrazolone, chemistry.chemical_element, Antineoplastic Agents, Crystallography, X-Ray, Ligands, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Ruthenium, Inorganic Chemistry, chemistry.chemical_compound, Coordination Complexes, Cell Line, Tumor, medicine, Humans, Hexamethylbenzene, Pyrazolones, Physical and Theoretical Chemistry, Methylene, chemistry.chemical_classification, Molecular Structure, 010405 organic chemistry, Ligand, Hydrazones, Nuclear magnetic resonance spectroscopy, Tautomer, 0104 chemical sciences, Models, Chemical, chemistry, Drug Design, Quantum Theory, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5325af47e7a2eae4fdcf754627dba3Test
    https://doi.org/10.1021/acs.inorgchem.8b01935Test


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  4. 4
    Development of C-Methyl Branched Purine Ribonucleoside Analogs: Chemistry, Biological Activity and Therapeutic Potential

    المؤلفون: Loredana Cappellacci, Riccardo Petrelli, Mario Grifantini

    المصدر: Current Medicinal Chemistry. 23:3118-3135

    مصطلحات موضوعية: Purine, Adenosine, Antineoplastic Agents, Hepacivirus, Pharmacology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Structure–activity relationship, Nucleotide, Purine Nucleotides, chemistry.chemical_classification, Receptor, Adenosine A1, 010405 organic chemistry, Organic Chemistry, Biological activity, Hepatitis C, Adenosine receptor, Adenosine A1 Receptor Agonists, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Ribonucleotide reductase, chemistry, Mechanism of action, Molecular Medicine, medicine.symptom, Multiple Myeloma, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f395e90fd41ec83a7fdbd4a3df7775eTest
    https://doi.org/10.2174/0929867323666160627100755Test


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  5. 5
    Nicotinamide Adenine Dinucleotide Based Therapeutics, Update

    المؤلفون: Rohit Singh, Krzysztof Felczak, Krzysztof W. Pankiewicz, Riccardo Petrelli

    المصدر: Current Medicinal Chemistry. 22:3991-4028

    مصطلحات موضوعية: DNA Ligases, Cell Survival, Cell, Antineoplastic Agents, Molecular Dynamics Simulation, Biology, Nicotinamide adenine dinucleotide, Biochemistry, Cofactor, chemistry.chemical_compound, IMP Dehydrogenase, Neoplasms, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Binding site, Pharmacology, chemistry.chemical_classification, Binding Sites, Bacteria, Kinase, Organic Chemistry, NAD, NAD binding, Phosphotransferases (Alcohol Group Acceptor), medicine.anatomical_structure, Enzyme, chemistry, biology.protein, Molecular Medicine, NAD+ kinase

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144d0b2b948c5fca571e9ffeefbc08d5Test
    https://doi.org/10.2174/0929867322666150821100720Test


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  6. 6
    Novel Inhibitors of Inosine Monophosphate Dehydrogenase in Patent Literature of the Last Decade

    المؤلفون: Daniel J. Wilson, Loredana Cappellacci, Riccardo Petrelli, Krzysztof Felczak, Patrizia Vita, Palmarisa Franchetti, Ilaria Torquati

    المصدر: Recent Patents on Anti-Cancer Drug Discovery. 8:103-125

    مصطلحات موضوعية: Cancer Research, Antiparasitic Agents, Drug Industry, Antiparasitic, medicine.drug_class, Patent literature, Antineoplastic Agents, General Medicine, Biology, Pharmacology, Antiviral Agents, IMPDH Inhibitors, Patents as Topic, IMP Dehydrogenase, Oncology, Biochemistry, IMP dehydrogenase, Drug Design, Drug Discovery, medicine, Animals, Humans, Pharmacology (medical), Enzyme Inhibitors, Immunosuppressive Agents

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a12daa0b69723e04789bbcf9e31666Test
    https://doi.org/10.2174/1574892811308020001Test


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  7. 7
    Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3′-C-methyl-ribonucleosides as antitumor agents

    المؤلفون: Mohineesh Kumar, Loredana Cappellacci, Palmarisa Franchetti, Riccardo Petrelli, Bingsen Zhou, Mario Grifantini, Yun Yen, Praveen Kusumanchi, Patrizia Vita, Hiremagalur N. Jayaram

    المصدر: European Journal of Medicinal Chemistry. 46:1499-1504

    مصطلحات موضوعية: Stereochemistry, Antineoplastic Agents, Chemical synthesis, Structure-Activity Relationship, Ribonucleotide Reductases, Drug Discovery, Tumor Cells, Cultured, medicine, Humans, Cell Proliferation, Pharmacology, chemistry.chemical_classification, Molecular Structure, Chemistry, Adenine, Organic Chemistry, Stereoisomerism, Biological activity, General Medicine, Ribonucleoside, Adenosine, Recombinant Proteins, Ribonucleoside-triphosphate reductase, Enzyme, Ribonucleotide reductase, Ribonucleosides, Caco-2 Cells, Drug Screening Assays, Antitumor, Nucleoside, HeLa Cells, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c931f278ea2e5cbc61280035ac47fceTest
    https://doi.org/10.1016/j.ejmech.2011.01.055Test


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  8. 8
    From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine

    المؤلفون: Hiremagalur N. Jayaram, Riccardo Petrelli, Fabio Del Bello, Praveen Kusumanchi, Maria Meli, Loredana Cappellacci, Patrizia Vita, Arianna Ferro, Munender Vodnala, Mario Grifantini, Anders Hofer, Ilaria Torquati, Manlio Tolomeo, Palmarisa Franchetti, Natale D'Alessandro

    المساهمون: Petrelli,R, Meli,M, Vita,P, Torquati,I, Ferro,A, Vodnala,M, D’Alessandro,N, Tolomeo,M, Del Bello,F, Kusumanchi,P, Franchetti,P, Grifantini,M, Jayaram,HN, Hofer,A, Cappellacci,L

    مصطلحات موضوعية: Deoxyribonucleoside triphosphate, Adenosine, Cell Survival, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Histone deacetylase (HDAC) inhibitor, Histone Deacetylases, Adenosine Triphosphate, Allosteric Regulation, Cell Line, Tumor, Drug Discovery, Ribonucleotide Reductases, medicine, Valproic acid, Humans, Ribonucleotide reductase (RR) inhibitor, Enzyme Inhibitors, Molecular Biology, 3′-C-methyladenosine, Nucleoside analogue, Kinase, Chemistry, Organic Chemistry, Apoptosi, Esters, Settore CHIM/08 - Chimica Farmaceutica, Hematological and solid tumor, Histone Deacetylase Inhibitors, Kinetics, Ribonucleotide reductase, Settore BIO/14 - Farmacologia, Molecular Medicine, Histone deacetylase, Nucleoside, Intracellular, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7fa06186da59ec3c75116b35373fdbTest
    http://hdl.handle.net/11581/338581Test


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  9. 9
    Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3’-C-methyladenosine in leukaemia cells

    المؤلفون: Riccardo Petrelli, Luisa Dusonchet, Antonello Mai, Loredana Cappellacci, Dante Rotili, Mario Grifantini, Philipp Saiko, Arianna Ferro, Thomas Szekeres, Manlio Tolomeo, Maria Meli

    المساهمون: Meli, M, Tolomeo, M, Grifantini, M, Mai, A, Cappellacci, L, Petrelli, R, Rotili, D, Ferro, A, Saiko, P, Szekeres, T, Dusonchet, L

    مصطلحات موضوعية: Cancer Research, Adenosine, HL60, Cell, Deoxyribonucleotides, Antineoplastic Agents, Apoptosis, HL-60 Cells, Ribonucleotide reductase inhibitor, Biology, Hydroxamic Acids, HDAC inhibitors, RR inhibitors, Apoptosis, Leukaemia, ROS, chemistry.chemical_compound, Ribonucleotide Reductases, medicine, Humans, Cell Proliferation, Leukemia, G1 Phase, Cell cycle, Histone Deacetylase Inhibitors, Ribonucleotide reductase, medicine.anatomical_structure, Trichostatin A, Oncology, chemistry, Cancer research, Settore BIO/14 - Farmacologia, Histone deacetylase, Reactive Oxygen Species, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2405ae7c2770eca9a50c4e85fa151ce2Test
    http://hdl.handle.net/11581/218598Test


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  10. 10
    Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure

    المؤلفون: Liqiang Chen, Daniel J. Wilson, Guangyao Gao, Hiremagalur N. Jayaram, Riccardo Petrelli, Garrett T. McLean, Krzysztof W. Pankiewicz, Yuk Y. Sham

    المصدر: Bioorganicmedicinal chemistry. 18(16)

    مصطلحات موضوعية: Inosine monophosphate, Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Hydroxamic Acids, Biochemistry, Histone Deacetylases, chemistry.chemical_compound, IMP Dehydrogenase, IMP dehydrogenase, Cell Line, Tumor, Neoplasms, Drug Discovery, Humans, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Hydroxamic acid, Organic Chemistry, Biological activity, Small molecule, Histone Deacetylase Inhibitors, Enzyme, chemistry, Cinnamates, Drug Resistance, Neoplasm, Molecular Medicine, Histone deacetylase, Linker

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40da161b3405492e251eba759a71081bTest
    https://pubmed.ncbi.nlm.nih.gov/20650640Test


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