المؤلفون: Francesca Foschi, Annachiara Tinivella, Valentina Crippa, Luca Pinzi, Luca Mologni, Daniele Passarella, Giulio Rastelli

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry. 38:239-245

مصطلحات موضوعية: Pharmacology, Lung Neoplasms, Antineoplastic Agents, General Medicine, ErbB Receptors, Structure-Activity Relationship, Drug Resistance, Neoplasm, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Mutation, Drug Discovery, allosteric inhibitors, anticancer drugs, drug design, EGFR inhibitors, Humans, Protein Kinase Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cda021b85828a0573d4727171f3d55Test
https://doi.org/10.1080/14756366.2022.2145284Test

المؤلفون: Barbara Rath, Adelina Plangger, Christoph Neumayer, Maximilian Hochmair, Gerhard Hamilton, Martin Funovics, Robert Zeillinger

المصدر: Investigational New Drugs. 40:215-223

مصطلحات موضوعية: Indoles, Lung Neoplasms, Afatinib, medicine.medical_treatment, Hyperphosphorylation, Antineoplastic Agents, Western blot, Carcinoma, Non-Small-Cell Lung, medicine, Humans, Pharmacology (medical), Cytotoxicity, Lung cancer, Protein Kinase Inhibitors, EGFR inhibitors, Pharmacology, Cisplatin, Chemotherapy, medicine.diagnostic_test, Chemistry, Cyclin-Dependent Kinase 4, medicine.disease, respiratory tract diseases, ErbB Receptors, Oncology, Mutation, Cancer research, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5312003ab72143a38194d617fd6188ecTest
https://doi.org/10.1007/s10637-021-01181-8Test

المؤلفون: Alexandra E. Rader, Carlota Rubio-Perez, Maxim V. Frolov, Mary Pasquinelli, Majd M. Ariss, Ryan D. Conrardy, Abul B. M. M. K. Islam, Alexa M. Gajda, Lawrence Eric Feldman, Cammille C. Go, Stefan J. Green, Alexandre Ferro Aissa, Elizaveta V. Benevolenskaya, Nuria Lopez-Bigas, Klara Valyi-Nagy

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-25 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Epithelial-Mesenchymal Transition, Cancer therapy, Cell Survival, Science, General Physics and Astronomy, Antineoplastic Agents, Drug resistance, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Receptor tyrosine kinase, Gene regulatory networks, 03 medical and health sciences, 0302 clinical medicine, Drug tolerance, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Humans, Cancer models, Protein Kinase Inhibitors, EGFR inhibitors, Multidisciplinary, Crizotinib, Drug discovery, Receptor Protein-Tyrosine Kinases, Drug Tolerance, U937 Cells, General Chemistry, respiratory tract diseases, ErbB Receptors, Gene Expression Regulation, Neoplastic, Drug Combinations, Cholesterol, 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Heterografts, Vesicle-mediated transport, Tyrosine kinase, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5567cf379b66251833dd58cf46aa6c95Test
https://doaj.org/article/07bdc3f7e13d4e018edb5f1887d9c903Test

المؤلفون: Kulbhushan Tikoo, Sandeep Singh, Nisha Sharma, Sajal Biswas, Gaurav Joshi, Raj Kumar, Tashvinder Singh, Manvendra Kumar, Zahid Rafiq Bhat, Sahil Arora

المصدر: Molecules
Volume 26
Issue 5
Molecules, Vol 26, Iss 1490, p 1490 (2021)

مصطلحات موضوعية: Lung Neoplasms, Pharmaceutical Science, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, T790M, Carcinoma, Non-Small-Cell Lung, Drug Discovery, Epidermal growth factor receptor, biology, Imidazoles, Gefitinib, ErbB Receptors, Molecular Docking Simulation, imidazo[1,2-a]quinoxaline, Chemistry (miscellaneous), Molecular Medicine, Erlotinib, medicine.drug, Antineoplastic Agents, mutant EGFR inhibitors, Article, lcsh:QD241-441, Erlotinib Hydrochloride, Inhibitory Concentration 50, Structure-Activity Relationship, anticancer agents, Quinoxaline, lcsh:Organic chemistry, Cell Line, Tumor, Quinoxalines, medicine, Humans, Physical and Theoretical Chemistry, Lung cancer, Protein Kinase Inhibitors, Cell Proliferation, 010405 organic chemistry, Organic Chemistry, non-covalent EGFR inhibitors, Wild type, Cancer, medicine.disease, 0104 chemical sciences, respiratory tract diseases, 010404 medicinal & biomolecular chemistry, chemistry, A549 Cells, Drug Resistance, Neoplasm, Mutation, Cancer research, biology.protein, Drug Screening Assays, Antitumor

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c3beb00e5f569c499c49be90ff8547Test
http://europepmc.org/articles/PMC7967119Test

المؤلفون: Yingqiang Liu, Mengzhen Lai, Shan Li, Yanan Wang, Fang Feng, Tao Zhang, Linjiang Tong, Mengge Zhang, Hao Chen, Yi Chen, Peiran Song, Yan Li, Gang Bai, Yi Ning, Haotian Tang, Yan Fang, Xiaoyun Lu, Meiyu Geng, Ke Ding, Ker Yu, Hua Xie, Jian Ding

المصدر: Cancer science. 113(2)

مصطلحات موضوعية: Cancer Research, Lung Neoplasms, Antineoplastic Agents, Apoptosis, medicine.disease_cause, T790M, Mice, In vivo, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, medicine, Animals, Humans, Osimertinib, Phosphorylation, Protein Kinase Inhibitors, EGFR inhibitors, Cell Proliferation, Mutation, Molecular Structure, Chemistry, Kinase, General Medicine, Xenograft Model Antitumor Assays, In vitro, respiratory tract diseases, ErbB Receptors, Oncology, Drug Resistance, Neoplasm, Cancer research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b7db792eafed79fde7e0631854a57cTest
https://pubmed.ncbi.nlm.nih.gov/34855271Test

المؤلفون: Darren Cross, Matthew J. Martin, Carine M. Guérot, Nicolas Floc'h, Clare Gregson, Jonathan P. Orme, Michal Bista, Lin Xue, Xu Li, Amar Rahi, Xiliang Zhao, Richard A. Ward, L. Evans, Gail L. Wrigley, Arash Mosallanejad, Tieguang Yao, Claire McWhirter, David J. Hargreaves, Nicola Colclough, Sue Bickerton, Darren Mckerrecher, Peter Barton, Yang Ye, Yi Liu, Marta Wylot, M. Raymond V. Finlay, Xiaoming Kang, Eva M. Lenz, Daniel O'Neill, Verity Talbot, Olivier Lorthioir, Paul D. Smith

المصدر: Journal of medicinal chemistry. 64(18)

مصطلحات موضوعية: Mice, Nude, Antineoplastic Agents, Mice, SCID, medicine.disease_cause, T790M, Organophosphorus Compounds, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, Osimertinib, Epidermal growth factor receptor, Lung cancer, Cell potency, Protein Kinase Inhibitors, EGFR inhibitors, Mutation, biology, Chemistry, medicine.disease, Xenograft Model Antitumor Assays, Rats, ErbB Receptors, Pyrimidines, Drug Resistance, Neoplasm, Cancer research, biology.protein, Molecular Medicine, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58199c545ee296c2c44cec7db12bfba5Test
https://pubmed.ncbi.nlm.nih.gov/34491761Test

المؤلفون: Kamrine E. Poels, Chelsi Napoli, Yosef Tobi, Helena A. Yu, Manli Shi, Weiwei Tan, Tom O. McDonald, Franziska Michor, Scott L. Weinrich, Shaon Chakrabarti, Yuli Wang, Aaron N. Hata, Adam J. Schoenfeld, Heidie Frisco-Cabanos, Alex Makhnin

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, Combination therapy, Cancer therapy, Cell Survival, Science, General Physics and Astronomy, Phases of clinical research, Antineoplastic Agents, General Biochemistry, Genetics and Molecular Biology, Article, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, Computer Simulation, Osimertinib, Dosing, Lung cancer, Quinazolinones, EGFR inhibitors, Acrylamides, Aniline Compounds, Models, Statistical, Multidisciplinary, business.industry, General Chemistry, Models, Theoretical, medicine.disease, Applied mathematics, Dacomitinib, ErbB Receptors, Clinical trial, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e0bdb52f3393033766da9119f216d6Test
http://europepmc.org/articles/PMC8211846Test

المؤلفون: Gege Gui, Charles G. Eberhart, Hongkai Ji, Weiqiang Zhou, Mingyao Ying, Shuli Xia, Bachuchu Lal, Yunqing Li, Yi Fu, Minling Gao, John Laterra

المصدر: Cancer Res

مصطلحات موضوعية: 0301 basic medicine, STAT3 Transcription Factor, Cancer Research, Cell, Antineoplastic Agents, Apoptosis, Mice, SCID, Biology, medicine.disease_cause, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Mice, Inbred NOD, Neurosphere, Radioresistance, medicine, Biomarkers, Tumor, Tumor Cells, Cultured, Animals, Humans, Osimertinib, Transcription factor, EGFR inhibitors, Cell Proliferation, Mutation, Acrylamides, Aniline Compounds, Hyperactivation, Brain Neoplasms, Xenograft Model Antitumor Assays, ErbB Receptors, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Cancer research, Female, Glioblastoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8713574eaa0f09e2168f87f01240957Test
https://europepmc.org/articles/PMC8277712Test/

المؤلفون: Riccardo Castelli, Laura Scalvini, Roberta Alfieri, Silvia La Monica, Marcello Tiseo

المصدر: Biochemical pharmacology. 190

مصطلحات موضوعية: 0301 basic medicine, Antineoplastic Agents, medicine.disease_cause, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Tumor growth, Osimertinib, In patient, Epidermal growth factor receptor, EGFR inhibitors, Pharmacology, Mutation, Lung, biology, business.industry, Point mutation, ErbB Receptors, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, biology.protein, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1f7c55d40ce9fd134d8684c0083b01Test
https://pubmed.ncbi.nlm.nih.gov/34097913Test

المؤلفون: Danlei Yu, Suresh S. Ramalingam, Zhen Chen, Taofeek K. Owonikoko, Shi-Yong Sun

المصدر: Oncogene

مصطلحات موضوعية: Cancer Research, Lung Neoplasms, Mutant, Mice, Nude, Antineoplastic Agents, Apoptosis, Biology, medicine.disease_cause, Article, T790M, Mice, Carcinoma, Non-Small-Cell Lung, Genetics, medicine, Tumor Cells, Cultured, Animals, Humans, Osimertinib, Molecular Biology, Gene, EGFR inhibitors, Cell Proliferation, Mutation, Acrylamides, Aniline Compounds, Lipogenesis, Xenograft Model Antitumor Assays, Sterol regulatory element-binding protein, ErbB Receptors, Gene Expression Regulation, Neoplastic, Proteolysis, Cancer research, Sterol Regulatory Element Binding Protein 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedc13dd6288c7cd043b2b3049194eecTest
https://pubmed.ncbi.nlm.nih.gov/34635799Test