Preparation and Antibacterial Activity of Thermo-Responsive Nanohydrogels from Qiai Essential Oil and Pluronic F108
| العنوان: | Preparation and Antibacterial Activity of Thermo-Responsive Nanohydrogels from Qiai Essential Oil and Pluronic F108 |
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| المؤلفون: | Abishek Jung Poudel, Shiming Li, Lin Xiao, Ying Yang, Feng He, Fu Xiang, Jianfeng Zhan, Shuxian Chen |
| المصدر: | Molecules, Vol 26, Iss 5771, p 5771 (2021) Molecules Volume 26 Issue 19 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Staphylococcus aureus, Artemisia argyi, Drug Compounding, Pharmaceutical Science, Organic chemistry, Poloxamer, Micelle, Article, essential oil, Analytical Chemistry, law.invention, qiai, QD241-441, antibacterial activity, law, Drug Discovery, Escherichia coli, Oils, Volatile, Physical and Theoretical Chemistry, Particle Size, Thermo responsive, Essential oil, Micelles, Aqueous solution, Microbial Viability, Chemistry, Plant Extracts, Antimicrobial, nanohydrogel, Anti-Bacterial Agents, Artemisia, Chemistry (miscellaneous), Delayed-Action Preparations, Molecular Medicine, Nanoparticles, Thermodynamics, thermo-responsive property, Antibacterial activity, Nuclear chemistry |
| الوصف: | Essential oils (EOs) have been used in cosmetics and food due to their antimicrobial and antiviral effects. However, the applications of EOs are compromised because of their poor aqueous solubility and high volatility. Qiai (Artemisia argyi Levl. et Van. var. argyi cv. Qiai) is a traditional Chinese herb and possesses strong antibacterial activity. Herein, we report an innovative formulation of EO as nanohydrogels, which were prepared through co-assembly of Qiai EO (QEO) and Pluronic F108 (PEG-b-PPG-b-PEG, or PF108) in aqueous solution. QEO was efficiently loaded in the PF108 micelles and formed nanohydrogels by heating the QEO/PF108 mixture solution to 37 °C, by the innate thermo-responsive property of PF108. The encapsulation efficiency and loading capacity of QEO reached 80.2% and 6.8%, respectively. QEO nanohydrogels were more stable than the free QEO with respect to volatilization. Sustained QEO release was achieved at body temperature using the QEO nanohydrogels, with the cumulative release rate reaching 95% in 35 h. In vitro antibacterial test indicated that the QEO nanohydrogels showed stronger antimicrobial activity against S. aureus and E. coli than the free QEO due to the enhanced stability and sustained-release characteristics. It has been attested that thermo-responsive QEO nanohydrogels have good potential as antibacterial cosmetics. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3587bfe15d5aa6244023ffcbfd5c594bTest https://www.mdpi.com/1420-3049/26/19/5771Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3587bfe15d5aa6244023ffcbfd5c594b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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