دورية أكاديمية
Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma.
| العنوان: | Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma. |
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| المؤلفون: | Perez, Cristina, Botta, Cirino, Zabaleta, Aintzane, Puig, Noemi, Cedena, Maria-Teresa, Goicoechea, Ibai, Alameda, Daniel, San José-Eneriz, Edurne, Merino, Juana, Rodríguez-Otero, Paula, Maia, Catarina, Alignani, Diego, Maiso, Patricia, Manrique, Irene, Lara-Astiaso, David, Vilas-Zornoza, Amaia, Sarvide, Sarai, Riillo, Caterina, Rossi, Marco, Rosiñol, Laura, Oriol, Albert, Blanchard, María-Jesús, Rios, Rafael, Sureda, Anna, Martin, Jesus, Martinez, Rafael, Bargay, Joan, de la Rubia, Javier, Hernandez, Miguel-Teodoro, Martinez-Lopez, Joaquin, Orfao, Alberto, Agirre, Xabier, Prosper, Felipe, Mateos, Maria-Victoria, Lahuerta, Juan-José, Blade, Joan, San-Miguel, Jesús F, Paiva, Bruno |
| سنة النشر: | 2020 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Antigens, CD, Female, Follow-Up Studies, Humans, Lymphocyte Count, Male, Middle Aged, Multiple Myeloma, Myeloid-Derived Suppressor Cells, Neoplasm Proteins, Neutrophils, T-Lymphocytes, Transcription, Genetic |
| الوصف: | Granulocytic myeloid-derived suppressor cells (G-MDSCs) promote tumor growth and immunosuppression in multiple myeloma (MM). However, their phenotype is not well established for accurate monitoring or clinical translation. We aimed to provide the phenotypic profile of G-MDSCs based on their prognostic significance in MM, immunosuppressive potential, and molecular program. The preestablished phenotype of G-MDSCs was evaluated in bone marrow samples from controls and MM patients using multidimensional flow cytometry; surprisingly, we found that CD11b+CD14-CD15+CD33+HLADR- cells overlapped with common eosinophils and neutrophils, which were not expanded in MM patients. Therefore, we relied on automated clustering to unbiasedly identify all granulocytic subsets in the tumor microenvironment: basophils, eosinophils, and immature, intermediate, and mature neutrophils. In a series of 267 newly diagnosed MM patients (GEM2012MENOS65 trial), only the frequency of mature neutrophils at diagnosis was significantly associated with patient outcome, and a high mature neutrophil/T-cell ratio resulted in inferior progression-free survival (P |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1528-0020 |
| العلاقة: | http://hdl.handle.net/10668/15418Test; https://ashpublications.org/blood/article-pdf/136/2/199/1747998/bloodbld2019004537.pdfTest |
| DOI: | 10.1182/blood.2019004537 |
| الإتاحة: | https://doi.org/10.1182/blood.2019004537Test http://hdl.handle.net/10668/15418Test https://ashpublications.org/blood/article-pdf/136/2/199/1747998/bloodbld2019004537.pdfTest |
| حقوق: | open access |
| رقم الانضمام: | edsbas.EB783FAF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15280020 |
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| DOI: | 10.1182/blood.2019004537 |