دورية أكاديمية
A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease
| العنوان: | A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease |
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| المؤلفون: | Al-Hassi, HO, Bernardo, D, Murugananthan, AU, Mann, ER, English, NR, Jones, A, Kamm, MA, Arebi, N, Hart, AL, Blakemore, AI, Stagg, AJ, Knight, SC |
| المصدر: | 761 ; 751 |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2012 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Immunology, INFLAMMATORY-BOWEL-DISEASE, CHEMOKINE RECEPTOR CCR7, MESENTERIC LYMPH-NODES, INTESTINAL INFLAMMATION, STIMULATORY CAPACITY, CYTOKINE PRODUCTION, SIGNALING PATHWAY, ADIPOSE-TISSUE, IN-VITRO, MATURATION, B7-1 Antigen, B7-2 Antigen, CD40 Antigens, Case-Control Studies, Cell Movement, Cellular Microenvironment, Colon, Crohn Disease, Dendritic Cells, Humans, Ileum, Leptin, Receptors, CCR7, STAT3 Transcription Factor, Antigens, CD40 |
| الوصف: | Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 expression on blood DC. Increased mesenteric fat and leptin occur early in Crohn's disease (CD), suggesting leptin-mediated change in intestinal CCR7 expression on DC as a pro-inflammatory mechanism. We have demonstrated CCR7 expression and capacity to migrate to its ligand macrophage inflammatory protein 3beta in normal human ileal DC but not colonic or blood DC. In CD, functional CCR7 was expressed on DC from all sites. Only DC populations containing CCR7-expressing cells produced LepRb; in vitro exposure to leptin also increased expression of functional CCR7 in intestinal DC in a dose-dependent manner. In conclusion, leptin may regulate DC migration from gut, in homeostatic and inflammatory conditions, providing a link between mesenteric obesity and inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1933-0219 |
| العلاقة: | Mucosal Immunology; http://hdl.handle.net/10044/1/63927Test; https://dx.doi.org/10.1038/mi.2012.113Test |
| DOI: | 10.1038/mi.2012.113 |
| الإتاحة: | https://doi.org/10.1038/mi.2012.113Test http://hdl.handle.net/10044/1/63927Test |
| حقوق: | © 2013 Society for Mucosal Immunology. This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http:// creativecommons.org/licenses/by-nc-nd/3.0 |
| رقم الانضمام: | edsbas.27E6D096 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19330219 |
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| DOI: | 10.1038/mi.2012.113 |