التفاصيل البيبلوغرافية
| العنوان: |
Dysregulation of germinal centres in autoimmune disease. |
| المؤلفون: |
Vinuesa, Carola G.1 carola.vinuesa@anu.edu.au, Sanz, Iñaki2, Cook, Matthew C.1,3, Sanz, Iñaki (AUTHOR) |
| المصدر: |
Nature Reviews Immunology. Dec2009, Vol. 9 Issue 12, p845-857. 13p. 2 Diagrams, 3 Charts. |
| مصطلحات موضوعية: |
*GERMINAL centers, *AUTOIMMUNE diseases, *B cells, *LYMPH nodes, *ANTIGEN presenting cells, *DENDRITIC cells, *ANTIGENS |
| مستخلص: |
In germinal centres, somatic hypermutation and B cell selection increase antibody affinity and specificity for the immunizing antigen, but the generation of autoreactive B cells is an inevitable by-product of this process. Here, we review the evidence that aberrant selection of these autoreactive B cells can arise from abnormalities in each of the germinal centre cellular constituents--B cells, T follicular helper cells, follicular dendritic cells and tingible body macrophages--or in the supply of antigen. As the progeny of germinal centre B cells includes long-lived plasma cells, selection of autoreactive B cells can propagate long-lived autoantibody responses and cause autoimmune diseases. Elucidation of crucial molecular signals in germinal centres has led to the identification of novel therapeutic targets. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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