دورية أكاديمية
MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A
| العنوان: | MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A |
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| المؤلفون: | Howson, LJ, Napolitani, G, Shepherd, D, Ghadbane, H, Kurupati, P, Preciado-Llanes, L, Rei, M, Dobinson, HC, Gibani, MM, Teng, KWW, Newell, EW, Veerapen, N, Besra, GS, Pollard, AJ, Cerundolo, V |
| بيانات النشر: | Nature Research (part of Springer Nature) |
| سنة النشر: | 2017 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, INVARIANT T-CELLS, RECEPTOR HETEROGENEITY, BACTERIAL-INFECTION, HIV-INFECTION, ACTIVATION, DIVERSITY, SUBSET, MUCOSA, BLOOD, Adolescent, Adult, Cell Line, Tumor, Cell Proliferation, Clone Cells, Healthy Volunteers, Host-Pathogen Interactions, Humans, Jurkat Cells, Leukocytes, Mononuclear, Middle Aged, Mucosal-Associated Invariant T Cells, Paratyphoid Fever, Receptors, Antigen, T-Cell |
| الوصف: | Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can detect bacteria-derived metabolites presented on MR1. Here we show, using a controlled infection of humans with live Salmonella enterica serovar Paratyphi A, that MAIT cells are activated during infection, an effect maintained even after antibiotic treatment. At the peak of infection MAIT cell T-cell receptor (TCR)β clonotypes that are over-represented prior to infection transiently contract. Select MAIT cell TCRβ clonotypes that expand after infection have stronger TCR-dependent activation than do contracted clonotypes. Our results demonstrate that host exposure to antigen may drive clonal expansion of MAIT cells with increased functional avidity, suggesting a role for specific vaccination strategies to increase the frequency and potency of MAIT cells to optimize effector function. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | Nature Communications; http://hdl.handle.net/10044/1/70486Test; https://doi.org/10.1038/s41467-017-02540-xTest |
| DOI: | 10.1038/s41467-017-02540-x |
| الإتاحة: | https://doi.org/10.1038/s41467-017-02540-xTest http://hdl.handle.net/10044/1/70486Test |
| حقوق: | © 2018 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0Test/. |
| رقم الانضمام: | edsbas.8D031D87 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-017-02540-x |