دورية أكاديمية
Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites
| العنوان: | Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites |
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| المؤلفون: | Coquet, Jonathan M, Schuijs, Martijn J, Smyth, Mark J, Deswarte, Kim, Beyaert, Rudi, Braun, Harald, Boon, Louis, Karlsson Hedestam, Gunilla B, Nutt, Steven L, Hammad, Hamida, Lambrecht, Bart N |
| المصدر: | Coquet , J M , Schuijs , M J , Smyth , M J , Deswarte , K , Beyaert , R , Braun , H , Boon , L , Karlsson Hedestam , G B , Nutt , S L , Hammad , H & Lambrecht , B N 2015 , ' Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites ' , Immunity , vol. 43 , no. 2 , pp. 318-30 . https://doi.org/10.1016/j.immuni.2015.07.015Test |
| سنة النشر: | 2015 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | Animals, Antigens, Dermatophagoides/immunology, Arthropod Proteins/immunology, Asthma/immunology, CD4-Positive T-Lymphocytes/immunology, Cells, Cultured, Cysteine Endopeptidases/immunology, Eosinophilia/immunology, Eosinophils/drug effects, Immunity, Cellular, Interleukins/administration & dosage, Lung/immunology, Mice, Inbred C57BL, Knockout, Pyroglyphidae/immunology, Receptors, Antigen, T-Cell/genetics, CXCR5/metabolism, Interleukin-21/administration & dosage, Th2 Cells/immunology |
| الوصف: | Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.immuni.2015.07.015 |
| الإتاحة: | https://doi.org/10.1016/j.immuni.2015.07.015Test https://curis.ku.dk/portal/da/publications/interleukin21producing-cd4-t-cells-promote-type-2-immunity-to-house-dust-mitesTest(6d142c1a-16fa-4732-a91f-e276eaf21f06).html |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.D14762D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.immuni.2015.07.015 |
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