دورية أكاديمية
A modular and controllable T cell therapy platform for acute myeloid leukemia
| العنوان: | A modular and controllable T cell therapy platform for acute myeloid leukemia |
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| المؤلفون: | Benmebarek, Mohamed-Reda, Cadilha, Bruno L., Herrmann, Monika, Lesch, Stefanie, Schmitt, Saskia, Stoiber, Stefan, Darwich, Abbass, Augsberger, Christian, Brauchle, Bettina, Rohrbacher, Lisa, Oner, Arman, Seifert, Matthias, Schwerdtfeger, Melanie, Gottschlich, Adrian, Rataj, Felicitas, Fenn, Nadja C., Klein, Christian, Subklewe, Marion, Endres, Stefan, Hopfner, Karl-Peter, Kobold, Sebastian |
| المصدر: | http://lobid.org/resources/99370672770606441Test#!, 35(8):2243-2257. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Leukemia, Experimental/pathology [MeSH], Female [MeSH], Acute myeloid leukaemia, T-Lymphocytes/immunology [MeSH], Humans [MeSH], Myeloid, Acute/immunology [MeSH], Experimental/immunology [MeSH], Mice, Inbred NOD [MeSH], Receptors, Antigen, T-Cell/immunology [MeSH], Animals [MeSH], SCID [MeSH], Tumor Cells, Cultured [MeSH], Mice [MeSH], Article, Experimental/therapy [MeSH], Xenograft Model Antitumor Assays [MeSH], T-Lymphocytes/transplantation [MeSH], Cancer immunotherapy, Targeted therapies, Acute/therapy [MeSH], Immunotherapy, Adoptive/methods [MeSH], Acute/pathology [MeSH] |
| الوصف: | Targeted T cell therapy is highly effective in disease settings where tumor antigens are uniformly expressed on malignant cells and where off-tumor on-target-associated toxicity is manageable. Although acute myeloid leukemia (AML) has in principle been shown to be a T cell-sensitive disease by the graft-versus-leukemia activity of allogeneic stem cell transplantation, T cell therapy has so far failed in this setting. This is largely due to the lack of target structures both sufficiently selective and uniformly expressed on AML, causing unacceptable myeloid cell toxicity. To address this, we developed a modular and controllable MHC-unrestricted adoptive T cell therapy platform tailored to AML. This platform combines synthetic agonistic receptor (SAR) -transduced T cells with AML-targeting tandem single chain variable fragment (scFv) constructs. Construct exchange allows SAR T cells to be redirected toward alternative targets, a process enabled by the short half-life and controllability of these antibody fragments. Combining SAR-transduced T cells with the scFv constructs resulted in selective killing of CD33 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6443854Test; https://doi.org/10.1038/s41375-020-01109-wTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789085Test/ |
| DOI: | 10.1038/s41375-020-01109-w |
| الإتاحة: | https://doi.org/10.1038/s41375-020-01109-wTest https://repository.publisso.de/resource/frl:6443854Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789085Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.28FD8D2B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41375-020-01109-w |
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