Antilipidemic Agents, III: Synthesis of Some Heterocyclic Derivatives of β-Sitosterol
| العنوان: | Antilipidemic Agents, III: Synthesis of Some Heterocyclic Derivatives of β-Sitosterol |
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| المؤلفون: | M. A. Khalil, Nargues S. Habib |
| المصدر: | Archiv der Pharmazie. 323:401-404 |
| بيانات النشر: | Wiley, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Bicyclic molecule, Stereochemistry, medicine.drug_class, Anticholesteremic Agents, Pharmaceutical Science, Carboxamide, Thioester, Sitosterols, Mice, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Animals, Phenols, Heterocyclic derivatives, Hypolipidemic Agents |
| الوصف: | Four novel series of heterocyclic derivatives of β-sitosterol were prepared by the reaction of 3-β-sitosterol hemisuccinate with SOCl2 then with thiols, amines or phenols. These series are: 3β-[(3-substituted-4(3H)-quinazolinon-2-yl)thiocarbonylproprionyloxy]stigmast-5-ene; 3β([4-substituted-5-(4-pyridyl)-4H-1,2,4-triazol-3-yl]thiocarbonylpropionyloxy}stigmast-5-ene; 3β-[(5-substituted-1,3,4-thiadiazol-2-yl)carbamoylpropionyloxy]stigmast-5-ene and 3β-substituted carbanoyl or oxycarbonylpropionyloxy)stigmast-5-ene. The antilipidemic activity of representative compounds was studied. Antilipidaemische Verbindungen, 3. Mitt.: Synthese einiger heterocyclischer Derivate des β-Sitosterols Vier neue Serien heterocyclischer Derivate des β-Sitosterols wurden hergestellt durch Reaktion von β-Sitosterol-hemisuccinat mit SOCl2, gefolgt von Thiolen, Aminen oder Phenolen. Es handelt sich um 3β-3β-[(3-substituierte-4(3H)-Chinazolinon-2-yl)thiocarbonylproprionyloxy]stigmast-5-en; 3β-([4-substituierte-5-(4-Pyridyl)-4H-1,2,4-triazol-3-yl]thiocarbonylpropionyloxy} stigmast-5-en; 3β-[(5-substituierte-1,3,4-Thiadiazol-2-yl]carbamoylpropionyloxy]stigmast-5-en und 3β-(substituierte carbamoyl oder oxycarbanylpropionyloxy)stigmast-5-ene. Die antilipidaemische Aktivitat reprasentativer Verbindungen wurde gepruft. |
| تدمد: | 1521-4184 0365-6233 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc708418af1834fa487f97c9f774b4eTest https://doi.org/10.1002/ardp.19903230705Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9dc708418af1834fa487f97c9f774b4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214184 03656233 |
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