دورية أكاديمية

Evolocumab and clinical outcomes in patients with cardiovascular disease

التفاصيل البيبلوغرافية
العنوان: Evolocumab and clinical outcomes in patients with cardiovascular disease
المؤلفون: Sabatine, M. S., Giugliano, R. P., Keech, A. C., Honarpour, N., Wiviott, S. D., Murphy, S. A., Kuder, J. F., Wang, H., Liu, T., Wasserman, S. M., Sever, P. S., Pedersen, T. R., Fish, M. P., Abrahamsen, T. E., Im, K., Kanevsky, E., Bonaca, M. P., Lira Pineda, A., Hanlon, K., Knusel, B., Somaratne, R., Kurtz, C., Scott, R., Accini Mendoza, J. L., Amerena, J., Badariene, J., Burgess, L., Ceska, R., Charng, M. J., Choi, D., Cobos, J. L., Dan, G. A., De Ferrari, G. M., Deedwania, P. C., Chopra, V. K., Erglis, A., Ezhov, M. V., Ferreira, J., Filipová, S., Gaciong, Z. A., Pasierski, T., Georgiev, B. G., Gonzalez-Galvez, G., Gouni-Berthold, I., Schäufele, T., Hirayama, A., Huber, K., Rammer, M., Kjaerulf Jensen, H., Wermuth, S., Jiang, L., Jukema, J. W., Kraydashenko, O., Leiter, L. A., Lewis, B. S., López-Miranda, J., Lorenzatti, A. J., Mach, F., McAdam, B., Nilsson, L., Olsson, A., Rallidis, L., Rogelio, G. G., Kerr Saraiva, J. F., Scheen, André, Schiele, F., Connolly, D., Siu, C. W., Tay, L., Thorgeirsson, G., Tikkanen, M. J., Tokgozoglu, S. L., Toth, K., Viigimaa, M., Wan Ahmad, W. A., Hennekens, C. H., Andreotti, F., Baigent, C., Brown, W. V., Davis, B. R., Newcomer, J. W., Wood, S. K., LaRosa, J., Ansell, B., Lowe, C., Zahn, L., Awtry, E., Berger, C., Croce, K., Desai, A., Gelfand, E., Ho, C., Leeman, D., Link, M., Norden, A., Pande, A., Rost, N., Ruberg, F., Silverman, S., Singhal, A., Vita, J., Murthy, D., Nigro, F., Rupka, D., Gossard, D., Gupta, M., Dowell, A., Mansour, S., Baass, A., Tziakas, D., Geadah, C., Dwivedi, S. K., Huynh, T., Peterson, S., Poirier, P., Sabe-Affaki, G., Vertes, G., Crowley, D., Duchesne, L., Pincetti Jofre, C. P., Potthoff Cardenas, S., Bousboulas, S., Parikh, K., Conejeros Kindel, C., Saavedra Gajardo, V. A., Lanas Zanetti, F., Sepulveda Varela, P. A., Stockins Fernandez, B. A., Li, W., Li, D., Zhao, S., Li, Z., Wang, J., Pothineni, R. B., Patsilinakos, S., Yang, Y., Zhang, L., Yang, P., Zhang, X., Huang, H., Xue, L., Zheng, Z., Huang, W., Dai, H., Solanki, B., Su, H., Mertzanos, G., Zeng, X., Zheng, Y., Tang, Y., Yao, Zhuhua, Sun, Y., Du, Y., Ge, Z., Yan, J., O'Donnell, M., Chen, X., Liu, F., Kubica, J., Pei, H., Yang, X., Cui, H., Gu, Y., Yang, Z., Li, J., Lian, Y., Crean, P., Cui, Y., Wang, D., Jiang, J., Panagoulis, C., Li, X., Chen, J., Mo, Z., Xu, P., He, Y., Zhou, C., Barton, J., Qu, P., Zhu, Y., Liu, Y., Shen, X., Bilianou, H., Gao, X., Terront Lozano, M. A., Moncada Corredor, M. A., Hernandez Triana, E., Botero Lopez, R., Shechter, M., Coronel Arroyo, J. A., Quintero Baiz, A. E., Sanchez Vallejo, G., Arana Londoño, C., Molina de Salazar, D. I., Skoumas, I., Castellanos Bueno, R., Manzur Jattin, F., Cure Cure, C. A., Sotomayor Herazo, A., Pentela-Nowicka, J., Spinar, J., Hala, T., Machkova, M., Klimsa, Z., Polasek, R., Jerabek, O., Elisaf, M., Kazdera, P., Pozdisek, Z., Vaclavik, J., Shotan, A., Frana, P., Elbl, L., Kucera, D., Kryza, R., Malecha, J., Reichert, P., Sochor, K., Manolis, A., Ludka, O., Kellnerova, I., Panov, A., Peterka, K., Zidkova, E., Cech, V., Brabec, T., Fiserova, N., Kvasnicka, J., Rosolova, H., Nemecek, E., Moschos, N., Adamkova, V., Klutstein, M., Dunaj, M., Pojsl, S., Cepelak, M., Podpera, I., Kuchar, L., Rysava, D., Burianova, H., Spinarova, L., Skrobakova, J., Kochiadakis, G., Chorin, E., Charvat, J., Homza, M., Zemanek, J., Koleckar, P., Karen, I., Krupicka, J., Blaha, V., Matuska, J., Brotanek, J., Cifkova, R., Gavish, D., Ntaios, G., Kuchar, R., Vomacka, Z., Kosek, Z., Hulinsky, V., Krejcova, H., Kuchar, J., Jelinek, Z., Jelinek, P., Markdanner Lindgren, L., Kracoff, O., Saetre Lihn, A., Richter, D., Korsgaard Thomsen, K., Bronnum-Schou, J., Nielsen, H., Nielsen, T., Egstrup, K., Klausen, I. C., Mickley, H., Hove, J., Atar, S., Jeppesen, J., Melchior, T., Athyros, V., Schmidt, E. B., Valter, I., Rosenthal, A., Kaik, J., Kork, A., Alt, I., Strand, J., Rigler, S., Nieminen, S., Kahri, J., Suomi, J., Raczak, G., Nyman, K., Strandberg, T. E., Piippo, T., Savolainen, M., Vikman, S., Pucheu, Y., Hasin, Y., Cariou, B., Henry, P., Ferrari, E., Montalescot, G., Kolovou, G., Ferrieres, J., Roubille, F., Bonnet, B., Angoulvant, D., Range, G., Schiff, E., Bammert, A., Delarche, N., Mariat, C., Cayla, G., Durlach, V., Danias, P., Coisne, D., Paillard, F., Rouzier, R., Goralski, M., Merlini, P., Khanoyan, P., Cottin, Y., Ziegler, O., Khalife, K., Le Corvoisier, P., Motreff, P., Melidonis, A., Spaulding, C., VanBelle, E., Bourhaial, H., Dabrowski, M., Opitz, C., Kahrmann, G., Contzen, C., Appel, K., Schenkenberger, I., Rinke, A., Trenk, D., Fan, K. Y. Y., Maus, O., Karakas, M., Bart, B., Hanefeld, M., Darius, H., Hetzel, G., Münzel, T., Wöhrle, J., Stawowy, P., Marten, I., Isermann, B., Siu, S. C., Kast, P., Rapezzi, C., Vorpahl, M., Bosiljanoff, P., Hengstenberg, C., Kassner, U., Salbach, P., Fischer, M., Hornyik, A., Lakatos, F., Zilahi, Z., Nagy, K., Pirro, M., Laszlo, Z., Wozniak, I., Peterfai, E., Lupkovics, G., Andreka, P., Merkely, B., Herczeg, B., Piros, G. A., Salamon, C., Mark, L., Gonnelli, S., Papp, A., Szakal, I., Cygler, J., Edes, I., Mohacsi, A., Tomcsanyi, J., Hajko, E., Nagy, A., Papp, E., Kiss, R., Floresta, A. M., Karadi, I., Sigurdsson, A., Jain, A., Kramarczuk, E., Pai, R., Kothiwale, V., Kulkarni, G., Mahajan, A., Aggarwal, S., Mehta, V., Mennuni, M., Rajadhyaksha, G., Joshi, A., Khandait, V., Parmar, M., Bystryk, L., Tyagi, S., Airody Govinda, R., Ardissino, D., Senni, M., Marenzi, G., Marcucci, R., Sampietro, T., Bubnova, M., Podolec, P., Cosmi, F., Perrone Filardi, P., De Caterina, R., Fedele, F., Moretti, L., Biasucci, L. M., Ferri, C., Go, Y., Kiyosue, A., Gordeev, I., Higashi, Y., Zieba, B., Tokunaga, T., Kawasaki, T., Sakagami, S., Namba, S., Saku, K., Oku, K., Arakawa, T., Iida, H., Osipova, I., Nakamura, Y., Yamamoto, K., Mackenzie, I., Hata, Y., Katsuda, Y., Koga, Y., Shimizu, M., Uehara, H., Kajiyama, S., Okamoto, H., Tereshenko, S., Shinozaki, T., Fujino, Y., Funazaki, T., Mosiewicz, J., Higa, N., Kaigawa, K., Koike, A., Nakane, H., Sato, K., Satoh, Y., Solovieva, E., Shirasawa, K., Sugino, H., Tanabe, J., Uemura, O., Dubaniewicz, W., Yoshimichi, G., Akai, A., Himeno, H., Inage, T., Inoko, M., Meshkov, A., Kadokami, T., Noguchi, Y., Yamashita, K., Yasumura, Y., Yuge, M., Banach, M., Hosokawa, S., Kawamitsu, K., Kozuma, K., Matsuo, H., Dixon, L., Nakashima, E., Okada, M., Wada, A., Yokoya, K., Iwade, K., Kawabata, K., Tyszecka, G., Tanno, H., Ako, J., Fujita, H., Zateyshchikov, D., Izumiya, Y., Kanno, M., Nunohiro, T., Ohmura, H., Ueno, T., Kakurina, N., Jasinkevica, I., Lepich, T., Stukena, I., Veze, I., Henderson, D., Eglite, R., Teterovska, D., Sime, I., Strazdiene, V., Venceviciene, L., Gustiene, O., Radzeviciene-Jurgute, R., Kucinskiene, A., Rychlewska-Hanczewska, A., Maskon, O., Tan, J. L., Lee, C. Y., Erng, T., Gan, H. W., Mohamed Yusof, A. K., Ramanathan, G. L., Liew, H., Lopez Alvarado, A., Nevarez Ruiz, L. A., De los Rios Ibarra, M. O., Guzik, T., Subramaniam, T., Bazzoni Ruiz, A. E., Ramos Lopez, G. A., Llamas Esperon, G. A., De la Peña Topete, G. D. J., Violante Ortiz, R. M., Illescas Diaz, J. J., Leon Gonzalez, S., Sanchez Diaz, C. J., Mendez Machado, G. F., Venegas Carrillo, L. A., Pella, D., Monteiro, P., Aldrete Velasco, J. A., Cardona Muñoz, E. G., Leiva Pons, J. L., Perez Alva, J. C., van der Zwaan, C., Oomen, A., van de Wal, R., Magro, M., Boswijk, D., Fulop, P., Janus, C., Pereira, H., Groutars, R., Tonino, W., Cornel, J. H., Oude Ophuis, A., Troquay, R., Liem, A., Westendorp, I., Van Hessen, M., Antalik, L., Lok, D., De Nooijer, C., Oliveira, L., Den Hartog, F., Van Beek, E., Bendermacher, P., Jansen, R., Römer, T., Rensing, B., Hersbach, F., Dzupina, A., Herrman, J., Ladyjanskaia, G., Karalis, I., Senior, R., Linssen, G., Bokern, M., Visman, A., Kooij, A., Monajemi, H., Lieverse, A., Banikova, A., Baker, J., Tie, S., Risberg, K., Hysing, J., Matos, P., Hoivik, H. O., Norheim, P., Solnor, L., Hovland, A., Kjaernli, T., Sosovec, D., Jocson, G., Coching, R. M., Batalla, E., Go, A., Habaluyas, R., Soares Goncalves, S., Barcinas, R., Sy, R. A., Estepar, R. A., Germar, A., Urgeova, L., Trebacz, J., Szymkowiak, K., Wnetrzak-Michalska, R., Kopaczewski, J., Przekwas-Jaruchowska, M., Kania, G., Leitao, A., Zabowka, M., Mirek-Bryniarska, E., Dabrowska, M., Saksena, R., Napora, P., Konieczny, M., Spyra, J., Lysek, R., Pijanowski, Z., Grzegorzewski, B., Bednarkiewicz, Z., Vasco Salgado, A., Kinasz, L., Antkowiak-Piatyszek, K., Herzog, W., Stania, K., Szpajer, M., Staneta, P., Skonieczny, G., Ksiezycka-Majczynska, E., Blicharski, T., Piepiorka, M., Wozakowska-Kaplon, B., Timoteo, A. T., Zechowicz, T., Mazur, J., Ilkowski, J., Lubiszewska, B., Hiczkiewicz, J., Wierzbicka, K., Kosior, D., Garbocz, P., Pintilei, E., Badila, E., Militaru, C., Tudoran, M., Hranai, M., Arsenescu-Georgescu, C., Capps, N., Mitu, F., Zdrenghea, D., Lighezan, D., Teodorescu, I., Popescu, M. I., Coman, I., Vintila, M. 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المصدر: New England Journal of Medicine, 376 (18), 1713-1722 (2017)
بيانات النشر: Massachussetts Medical Society
سنة النشر: 2017
المجموعة: University of Liège: ORBi (Open Repository and Bibliography)
مصطلحات موضوعية: PCSK9 protein, human, Article, Cardiovascular Diseases, Aged, Antibodies, Monoclonal, Anticholesteremic Agents, Atherosclerosis, Cholesterol, LDL, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Incidence, Least-Squares Analysis, Male, Middle Aged, Proprotein Convertase 9, Human health sciences, Endocrinology, metabolism & nutrition, Pharmacy, pharmacology & toxicology, Cardiovascular & respiratory systems
الوصف: peer reviewed ; BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0028-4793
1533-4406
العلاقة: urn:issn:0028-4793; urn:issn:1533-4406; https://orbi.uliege.be/handle/2268/235343Test; info:hdl:2268/235343; scopus-id:2-s2.0-85017341929; info:pmid:28304224
DOI: 10.1056/NEJMoa1615664
الإتاحة: https://doi.org/10.1056/NEJMoa1615664Test
https://orbi.uliege.be/handle/2268/235343Test
حقوق: restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess
رقم الانضمام: edsbas.6218D789
قاعدة البيانات: BASE
الوصف
تدمد:00284793
15334406
DOI:10.1056/NEJMoa1615664