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A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

التفاصيل البيبلوغرافية
العنوان: A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
المؤلفون: Encinas, Cristina, Hernandez-Rivas, José-Ãngel, Oriol, Albert, Rosiñol, Laura, Blanchard, María Jesús, Bellón, José-María, García-Sanz, Ramón, de la Rubia, Javier, López de la Guía, Ana, Jímenez-Ubieto, Ana, Jarque, Isidro, Iñigo, Belén, Dourdil, Victoria, De Arriba, Felipe, Cuéllar Pérez-Ãvila, Clara, Gonzalez, Yolanda, Hernández, Miguel-Teodoro, Bargay, Joan, Granell, Miquel, Rodríguez-Otero, Paula, Silvent, Maialen, Cabrera, Carmen, Rios, Rafael, Alegre, Adrián, Gironella, Mercedes, Gonzalez, Marta-Sonia, Sureda, Anna, Sampol, Antonia, Ocio, Enrique M., Krsnik, Isabel, García, Antonio, García-Mateo, Aránzazu, Soler, Joan-Alfons, Martín Sánchez, Jesús, Arguiñano, José M, Mateos, M. V., Bladé Creixenti, Juan, San-Miguel, J, Lahuerta, J. J, Martínez-López, Joaquín
سنة النشر: 2022
المجموعة: Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB
مصطلحات موضوعية: Antibiotic Prophylaxis, Humans, Male, Multiple Myeloma
الوصف: Altres ajuts: PETHEMA (Spanish Program for the Treatment of Hematological Diseases), Madrid, Spain ; Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin ≤30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 20445385
العلاقة: Blood Cancer Journal; Vol. 12 Núm. 4 (april 2022), p. 68; https://ddd.uab.cat/record/280855Test; urn:10.1038/s41408-022-00652-2; urn:oai:ddd.uab.cat:280855; urn:scopus_id:85128796138; urn:articleid:20445385v12n4p68; urn:pmid:35440057; urn:pmc-uid:9018751; urn:pmcid:PMC9018751; urn:oai:pubmedcentral.nih.gov:9018751
الإتاحة: https://ddd.uab.cat/record/280855Test
حقوق: open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.F3CAC34A
قاعدة البيانات: BASE
الوصف
تدمد:20445385