Antibacterial oral sprays from kaffir lime (Citrus hystrix DC.) fruit peel oil and leaf oil and their activities against respiratory tract pathogens
| العنوان: | Antibacterial oral sprays from kaffir lime (Citrus hystrix DC.) fruit peel oil and leaf oil and their activities against respiratory tract pathogens |
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| المؤلفون: | Somporn Srifuengfung, Veena Satitpatipan, Varaporn Buraphacheep Junyaprasert, Vimol Srisukh, Nuntavan Bunyapraphatsara, Walla Tungrugsasut, Chanwit Tribuddharat |
| المصدر: | Journal of Traditional and Complementary Medicine, Vol 10, Iss 6, Pp 594-598 (2020) Journal of Traditional and Complementary Medicine |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | food.ingredient, Short Communication, MBC, Minimal bactericidal concentration, mm, millimeter, lcsh:Medicine, Alpha-terpineol, Biology, mg, milligram, medicine.disease_cause, Essential oil, Terpinene-4-ol, law.invention, Haemophilus influenzae, chemistry.chemical_compound, food, law, Streptococcus pneumoniae, KLO, Kaffir lime oil, medicine, KLLO, Kaffir lime leaf oil, Food science, ml, milliliter, μl, microliter, MIC, Minimal inhibitory concentration, %v/v, percent in volume by volume, Sore throat, min, minute, Broth microdilution, lcsh:R, Citronellal, Pharyngitis, ˚C, Degree Celsius, Kaffir Lime, ppm, part per million, μm, micrometer, Complementary and alternative medicine, chemistry, Staphylococcus aureus, g, gram, Antibacterial activity |
| الوصف: | Background and aim Kaffir lime fruit peel oil and Kaffir lime leaf oil have been reported for their activities against respiratory tract pathogens. The purpose of the study was to develop clear oral sprays to be used as a first-defense oral spray. Experimental procedure Clear antibacterial oral sprays were prepared and analyzed for their respective active major compounds, using GC-MS. The sprays were tested against a Gr. A streptococcal clinical isolate and 3 standard respiratory tract pathogens, using Broth microdilution method. A 4-month stability test was carried out as well. Results and conclusion Six clear oral sprays, three formulae composed of Kaffir lime fruit peel oil (6, 10, 13%v/v KLO) and the other three formulae containing Kaffir lime leaf oil (4, 8, 12%v/v KLLO), were developed. The active compounds in KLO were α-terpineol and terpinene-4-ol whereas that in KLLO was citronellal. All oral sprays exhibited antibacterial activity against one Group A streptococcal clinical isolate and three respiratory pathogenic pathogens, Staphylococcus aureus ATCC 29213, Streptococcus pneumoniae ATCC 49619, and Haemophilus influenzae ATCC 49247, among which the strongest activity was against H. influenzae ATCC 49247. The antibacterial activity of all oral sprays remained unchanged in an accelerated stability test, at 4, 30, and 45 °C under 75% relative humidity, throughout the 4-month storage. Graphical abstract Image 101 Highlights of the findings and novelties • Clear antibacterial oral sprays were prepared. • Active major compounds were alpha-terpineol, terpinene-4-ol, and citronellal. • The sprays showed strongest activities against Haemophilus influenzae ATCC 49247. • The antibacterial activity was shown throughout 4-month storage. |
| اللغة: | English |
| تدمد: | 2225-4110 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e09683bc4b1090868664b968614ccbTest http://www.sciencedirect.com/science/article/pii/S2225411018310368Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9e09683bc4b1090868664b968614ccb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22254110 |
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