Exercise efficiency impairment in metabolic myopathies
| العنوان: | Exercise efficiency impairment in metabolic myopathies |
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| المؤلفون: | Fabrice Rannou, Jean-Baptiste Noury, Pascale Marcorelles, Fabien Zagnoli, François Petit |
| المساهمون: | Service de Neurologie [Brest], Hôpital d'Instruction des Armées 'Clermont-Tonnerre' (HIA), Université de Bordeaux (UB), Service d'Anatomie Pathologique, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, CRNH Auvergne, Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-65770-y⟩ Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-65770-y⟩ |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | myalgia, Male, Purine-Pyrimidine Metabolism, Inborn Errors, Mitochondrial Diseases, [SDV]Life Sciences [q-bio], Respiratory chain, lcsh:Medicine, Incremental exercise, AMP Deaminase, 0302 clinical medicine, lcsh:Science, ComputingMilieux_MISCELLANEOUS, Multidisciplinary, Exercise Tolerance, medicine.diagnostic_test, Anthropometry, Neuromuscular disease, Middle Aged, medicine.anatomical_structure, Cardiology, Female, Analysis of variance, medicine.symptom, Adult, medicine.medical_specialty, Adolescent, Exercise intolerance, Muscle disorder, Article, 03 medical and health sciences, Young Adult, Oxygen Consumption, Muscular Diseases, Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Exercise, Muscle biopsy, Glycogen Storage Disease Type VII, business.industry, lcsh:R, Skeletal muscle, 030229 sport sciences, Energy metabolism, Myalgia, Exercise Test, Glycogen Storage Disease Type V, lcsh:Q, business, 030217 neurology & neurosurgery |
| الوصف: | Metabolic myopathies are muscle disorders caused by a biochemical defect of the skeletal muscle energy system resulting in exercise intolerance. The primary aim of this research was to evaluate the oxygen cost (∆V’O2/∆Work-Rate) during incremental exercise in patients with metabolic myopathies as compared with patients with non-metabolic myalgia and healthy subjects. The study groups consisted of eight patients with muscle glycogenoses (one Tarui and seven McArdle diseases), seven patients with a complete and twenty-two patients with a partial myoadenylate deaminase (MAD) deficiency in muscle biopsy, five patients with a respiratory chain deficiency, seventy-three patients with exercise intolerance and normal muscle biopsy (non-metabolic myalgia), and twenty-eight healthy controls. The subjects underwent a cardiopulmonary exercise test (CPX Medgraphics) performed on a bicycle ergometer. Pulmonary V’O2 was measured breath-by-breath throughout the incremental test. The ∆V’O2/∆Work-Rate slope for exercise was determined by linear regression analysis. Lower oxygen consumption (peak percent of predicted, mean ± SD; p 2/∆Work-Rate slope (mLO2.min−1.W−1) was increased in patients with MAD absent (12.6 ± 1.5), MAD decreased (11.3 ± 1.1), glycogenoses (14.0 ± 2.5), respiratory chain defects (13.1 ± 1.2), and patients with non-metabolic myalgia (11.3 ± 1.3) compared with control subjects (10.2 ± 0.7; p 2 consumption during daily life-submaximal exercises. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8761049fac9f7218520a5847f1a6c3Test http://link.springer.com/article/10.1038/s41598-020-65770-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0e8761049fac9f7218520a5847f1a6c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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