التفاصيل البيبلوغرافية
| العنوان: |
Severe Fatigue and Persistent Symptoms at 3 Months Following Severe Acute Respiratory Syndrome Coronavirus 2 Infections During the Pre-Delta, Delta, and Omicron Time Periods: A Multicenter Prospective Cohort Study. |
| المؤلفون: |
Gottlieb, Michael, Wang, Ralph C, Yu, Huihui, Spatz, Erica S, Montoy, Juan Carlos C, Rodriguez, Robert M, Chang, Anna Marie, Elmore, Joann G, Hannikainen, Paavali A, Hill, Mandy, Huebinger, Ryan M, Idris, Ahamed H, Lin, Zhenqiu, Koo, Katherine, McDonald, Samuel, O'Laughlin, Kelli N, Plumb, Ian D, Santangelo, Michelle, Saydah, Sharon, Willis, Michael, Wisk, Lauren E, Venkatesh, Arjun, Stephens, Kari A, Weinstein, Robert A, Innovative Support for Patients with SARS-CoV-2 Infections Registry Group |
| المصدر: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 76, iss 11 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE) Group, Humans, Fatigue, Prospective Studies, Adult, COVID-19, SARS-CoV-2, COVID-19 Testing, Delta, Long COVID, Omicron, Pneumonia, Pneumonia & Influenza, Infectious Diseases, Lung, Prevention, Clinical Research, Emerging Infectious Diseases, Biodefense, Vaccine Related, Immunization, Infection, Good Health and Well Being, Biological Sciences, Medical and Health Sciences, Microbiology, socio, anthro-se |
| الوقت: |
1930 - 1941 |
| الوصف: |
BackgroundMost research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants focuses on initial symptomatology with limited longer-term data. We characterized prevalences of prolonged symptoms 3 months post-SARS-CoV-2 infection across 3 variant time-periods (pre-Delta, Delta, and Omicron).MethodsThis multicenter prospective cohort study of adults with acute illness tested for SARS-CoV-2 compared fatigue severity, fatigue symptoms, organ system-based symptoms, and ≥3 symptoms across variants among participants with a positive ("COVID-positive") or negative SARS-CoV-2 test ("COVID-negative") at 3 months after SARS-CoV-2 testing. Variant periods were defined by dates with ≥50% dominant strain. We performed multivariable logistic regression modeling to estimate independent effects of variants adjusting for sociodemographics, baseline health, and vaccine status.ResultsThe study included 2402 COVID-positive and 821 COVID-negative participants. Among COVID-positives, 463 (19.3%) were pre-Delta, 1198 (49.9%) Delta, and 741 (30.8%) Omicron. The pre-Delta COVID-positive cohort exhibited more prolonged severe fatigue (16.7% vs 11.5% vs 12.3%; P = .017) and presence of ≥3 prolonged symptoms (28.4% vs 21.7% vs 16.0%; P < .001) compared with the Delta and Omicron cohorts. No differences were seen in the COVID-negatives across time-periods. In multivariable models adjusted for vaccination, severe fatigue and odds of having ≥3 symptoms were no longer significant across variants.ConclusionsProlonged symptoms following SARS-CoV-2 infection were more common among participants infected during pre-Delta than with Delta and Omicron; however, these differences were no longer significant after adjusting for vaccination status, suggesting a beneficial effect of vaccination on risk of long-term symptoms. Clinical Trials Registration. NCT04610515. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://escholarship.org/uc/item/2d14j7xmTest |
| الإتاحة: |
https://escholarship.org/uc/item/2d14j7xmTest |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.C52A1A8B |
| قاعدة البيانات: |
BASE |
