التفاصيل البيبلوغرافية
| العنوان: |
Autologous peripheral blood-derived stem cells transplantation for treatment of no-option angiitis-induced critical limb ischemia: 10-year management experience. |
| المؤلفون: |
Fang, Gang, Jiang, Xiaolang, Fang, Yuan, Pan, Tianyue, Liu, Hao, Ren, Bichen, Wei, Zheng, Gu, Shiyang, Chen, Bin, Jiang, Junhao, Shi, Yun, Guo, Daqiao, Liu, Peng, Fu, Weiguo, Dong, Zhihui |
| المصدر: |
Stem Cell Research & Therapy; 10/28/2020, Vol. 11 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
STEM cell transplantation, STEM cell treatment, LIMB salvage, ISCHEMIA, ANKLE brachial index |
| مستخلص: |
Background: Previous studies have demonstrated that no-option angiitis-induced critical limb ischemia (NO-AICLI) could be significantly improved by transplantation of peripheral blood-derived stem cells (PBDSCs). Additionally, a randomized controlled trial (RCT) recently conducted by us suggested that peripheral blood-derived purified CD34+ cells (PCCs) were not inferior to non-purified peripheral blood mononuclear cells (PBMNCs) at limb salvage in treatment of NO-AICLI. However, most of these clinical trials whether RCT or single-arm studies were characterized with a small sample size and absence of long-term outcomes. Methods: To analyze long-term clinical outcomes of PBDSCs transplantation for NO-AICLI, we reviewed clinical data of patients with NO-AICLI receiving PBDSCs transplantation at our center during the past decade. Meanwhile, we first compared the long-term safety and efficacy of intramuscular transplantation of PCCs versus PBMNCs in a sizable number of patients with NO-AICLI. Results: From May 2009 to December 2019, a total of 160 patients with NO-AICLI patients were treated by PBDSCs transplantation (82 with PCCs, 78 with PBMNCs) at our center. Baseline characteristics between two groups were similar. Up to June 2020, the mean follow-up period was 46.6 ± 35.3 months. No critical adverse events were observed in either group. There was one death during the follow-up period. A total of eight major amputations occurred. The cumulative major amputation-free survival (MAFS) rate at 5 years after PBDSCs transplantation was 94.4%, without difference between two groups (P =.855). Wound healing, rest pain, pain-free walking time, ankle-brachial index, transcutaneous oxygen pressure, and quality of life (QoL) also significantly improved after PBDSCs transplantation. Conclusions: Autologous PBDSCs intramuscular transplantation could significantly decrease the major amputation rates and improve the QoL in patients with NO-AICLI. Long-term observation of a large sample of patients confirmed that the clinical benefits of PBDSCs transplantation were durable, without difference between the PCCs and PBMNCs groups. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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