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المؤلفون: Hiroshi Tazawa, Satoru Kikuchi, Hiroki Kajioka, Shunsuke Kagawa, Atene Ito, Shinji Kuroda, Toshiyoshi Fujiwara, Ryuichi Yoshida, Shuichi Sakamoto, Kazuhiro Noma, Yuzo Umeda, Masashi Yoshimoto
المصدر: Cancer Letters. 497:1-3
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Epithelial-Mesenchymal Transition, Neutrophils, Thrombomodulin, Inflammation, Apoptosis, Extracellular Traps, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, Pancreatic cancer, Tumor Cells, Cultured, Medicine, Animals, Humans, Epithelial–mesenchymal transition, Cell Proliferation, HMGB1, Epithelial to mesenchymal transition, business.industry, Liver Neoplasms, Neutrophil extracellular traps, medicine.disease, Xenograft Model Antitumor Assays, Extravasation, Ischemia-reperfusion model, Pancreatic Neoplasms, Disease Models, Animal, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Reperfusion Injury, Cancer cell, Cancer research, Carcinogens, Tetradecanoylphorbol Acetate, Phorbol 12-myristate 13-acetate, medicine.symptom, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e94073d5f6cd3af10e6c9cb47038ca6Test
https://ousar.lib.okayama-u.ac.jp/61273Test -
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المؤلفون: Jianglei Chen, Yanhong Du, Wenjing Wu, Siribhinya Benyajati, Dibyendu Chakraborty, Yusuke Takahashi, Xiang Ma, Yangxiong Li, Wentao Liang, Jian Xing Ma
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Very Low-Density Lipoprotein Receptor, Retinal Pigment Epithelium, Interphotoreceptor matrix, Biochemistry, LRP6, low-density lipoprotein receptor–related protein 6, Macular Degeneration, Mice, shedding, RFP, red fluorescent protein, AMD, age-related macular degeneration, VLDLRI, VLDLR variant I, Wnt Signaling Pathway, Mice, Knockout, lipoprotein receptor, Chemistry, Wnt signaling pathway, MT1, membrane type 1, LRP6, IPM, interphotoreceptor matrix, TIMP3, tissue inhibitor of metalloproteinase 3, gRNA, guide RNA, TCF, T-cell factor, Cell biology, MMP, matrix metalloproteinase, medicine.anatomical_structure, Ectodomain, VLDLRII, VLDLR variant II, LDLR, low-density lipoprotein receptor, Research Article, PMA, phorbol 12-myristate 13-acetate, 5-FAM, 5-carboxyfluorescein, RPE, retinal pigment epithelium, VLDL receptor, TNFα, tumor necrosis factor alpha, ADAM17 Protein, H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate, ROS, reactive oxygen species, Downregulation and upregulation, Protein Domains, CHX, cycloheximide, sVLDLR, soluble ectodomain of VLDLR, PKC, protein kinase C, medicine, Animals, Humans, Molecular Biology, Retinal pigment epithelium, ADAM, Cell Biology, VLDLR, very low-density lipoprotein receptor, Wnt signaling, Disease Models, Animal, Receptors, LDL, DCF, dichlorofluorescein, retinal degeneration, BSA, bovine serum albumin, ADAM17, a disintegrin and metalloprotease 17
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5974b7bf59a8584fad41d82734272403Test
https://pubmed.ncbi.nlm.nih.gov/34509473Test -
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المؤلفون: Nigel J. Pyne, Rothwelle J. Tate, Federico Torta, David R. Adams, Jeongah Oh, Susan Pyne, Ryan D. R. Brown, Margaret R. Cunningham, Ben E.P. Veerman
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, translocation, Chromosomal translocation, plasma membrane, Biochemistry, chemistry.chemical_compound, AUC, area under the curve, Mice, Sph, sphingosine, Sphingosine, R-loop, regulatory loop, structural biology, PA, phosphatidic acid, ERK, extracellular signal–regulated protein kinase, PLAs, proximity ligation assays, chemistry.chemical_classification, biology, Chemistry, PS, phosphatidylserine, CTD, C-terminal domain, Cell biology, Amino acid, Phosphotransferases (Alcohol Group Acceptor), Protein Transport, Sphingosine kinase 1, PLD2, phospholipase D2, PM, plasma membrane, MCF-7 Cells, Female, fluorescence, FIPI, N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide hydrochloride, Research Article, PMA, phorbol 12-myristate 13-acetate, LBL-1, lipid-binding loop 1, hSK1, human SK1, Breast Neoplasms, SK1, sphingosine kinase 1, RS, RC0254, 03 medical and health sciences, Membrane Microdomains, Animals, Humans, enzyme mechanism, Sphingosine-1-phosphate, NTD, N-terminal domain, Sphingosine-1-phosphate (S1P), PLD, phospholipase D, Molecular Biology, S1P, sphingosine-1-phosphate, 030102 biochemistry & molecular biology, Phospholipase D, Cell Membrane, Cell Biology, Lipid signaling, QR, 030104 developmental biology, mSK1, mouse SK1, Phorbol, biology.protein, BuMe, butanol:methanol, mutagenesis in vitro, lipid signaling, FCS, fetal calf serum, Lysophospholipids, Protein Multimerization, DAPI, 4′,6-diamidino-2-phenylindole
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3396474707d566c93b76fdd17ca71cTest
http://europepmc.org/articles/PMC8135045Test -
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المؤلفون: Nobuhiko Miwa, Li Xiao
المصدر: Cells
Cells, Vol 10, Iss 626, p 626 (2021)
Volume 10
Issue 3مصطلحات موضوعية: Keratinocytes, medicine.medical_specialty, Anti-Inflammatory Agents, Subcutaneous Fat, Adipose tissue, hydrogen peroxide, medicine.disease_cause, Article, Antioxidants, adipogenesis, chemistry.chemical_compound, Mice, Internal medicine, adipose equivalents, medicine, Adipocytes, metabolic disorders, Animals, Humans, Secretion, hydrogen-rich water, Hydrogen peroxide, lcsh:QH301-705.5, chemistry.chemical_classification, reactive oxygen species, Reactive oxygen species, IL-6, Interleukin-6, Water, General Medicine, nano-bubbles, Coculture Techniques, HaCaT, Oxidative Stress, Endocrinology, lcsh:Biology (General), chemistry, Adipogenesis, inflammation, Phorbol, Nanoparticles, Tetradecanoylphorbol Acetate, Oxidative stress, phorbol 12-myristate 13-acetate, Hydrogen, Signal Transduction
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152f753db37d549687cc12ff803d5fe0Test
http://europepmc.org/articles/PMC7998368Test -
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المؤلفون: Gwen Lomberk, Adebowale O. Bamidele, Mary R. Sagstetter, Manuel Bonfim Braga Neto, Olga F. Sarmento, Subra Kugathasan, Raul Urrutia, Michelle Gonzalez, William A. Faubion, Phyllis A. Svingen
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 55-71 (2019)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: Male, 0301 basic medicine, Cell Separation, T-Lymphocytes, Regulatory, Regulatory T Cells, Jurkat Cells, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, co-IP, co-immunoprecipitation, Phosphorylation, Original Research, IBD, inflammatory bowel disease, Janus kinase 1, biology, Chemistry, EZH2, Polycomb Repressive Complex 2, Gastroenterology, FOXP3, Forkhead Transcription Factors, H3K27me3, trimethylated histone H3 at lysine 27, hemic and immune systems, C232, cysteine 232, Middle Aged, Proinflammatory Cytokine, 3. Good health, Chromatin, Intestines, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, Female, Epigenetics, 030211 gastroenterology & hepatology, ChIP, chromatin-immunoprecipitation, JAK, Janus kinase, Co-Repressor Proteins, Protein Binding, Signal Transduction, Crohn’s Disease, Adult, STAT3 Transcription Factor, PMA, phorbol 12-myristate 13-acetate, PBMC, peripheral blood mononuclear cell, Regulatory T cell, PBS, phosphate-buffered saline, SUZ12, suppressor of zeste, Treg, regulatory T cell, chemical and pharmacologic phenomena, macromolecular substances, Proinflammatory cytokine, 03 medical and health sciences, EED, embryonic ectoderm development, CD, Crohn’s disease, medicine, Animals, Humans, LZ, leucine zipper, Enhancer of Zeste Homolog 2 Protein, lcsh:RC799-869, Phosphotyrosine, Interleukin 6, Th, T helper, Transcription factor, Janus Kinases, Cell Nucleus, Inflammation, FOXP3, forkhead domain-containing X-chromosome–encoded protein, Hepatology, Interleukin-6, PLA, proximity ligation assay, Inflammatory Bowel Diseases, WT, wild-type, IL, interleukin, Mice, Inbred C57BL, 030104 developmental biology, Mutation, IPEX, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, biology.protein, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, FCS, fetal calf serum, PRC2, polycomb repressive complex 2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12e433b1850cff302bda788632ed012Test
http://www.sciencedirect.com/science/article/pii/S2352345X18301267Test -
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المؤلفون: Marco A. Ramos, Ruth Heidelberger, Roberto J. Alcazar-Felix, Roberto Adachi, Eduardo I. Cardenas, Alan R. Burns, Alejandro I. Rodarte, Ricardo Treviño González, Rodolfo A. Cardenas, Alejandro Isaza, Elizabeth Sanchez
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, CTMC, connective tissue MC, GS, series conductance, CAE, chloroacetate esterase, DNP, 2,4-dinitrophenol, CTX, cholera toxin, GTPγS, guanosine 5′-3-O-(thio)triphosphate, Biochemistry, Wsh, MC-deficient KitW-sh/W-sh mouse, Abnormal platelet morphology, Mice, Gm, membrane conductance, MC, mast cell, MMC, mucosal MC, bm, basement membrane, DT, diphtheria toxin, PCMCs, peritoneal-cell-derived MCs, BMMCs, bone-marrow-derived MCs, Platelet, Mast Cells, MFI, mean fluorescence intensity, Munc, mammalian homolog of C. elegans uncoordinated gene, Mice, Knockout, Chemistry, Degranulation, Qb-SNARE Proteins, Cm, membrane capacitance, Mast cell, humanities, Cell biology, Vesicle-associated membrane protein, medicine.anatomical_structure, F, farad, Stx, syntaxin, Connective Tissue, Pf4, platelet factor 4, SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptors, ΔCm, capacitance gain, platelets, SNAP23, AU, arbitrary units, exocytosis, Research Article, Blood Platelets, PMA, phorbol 12-myristate 13-acetate, S, siemens, SNARE proteins, FSC, forward scatter, Connective tissue, Exocytosis, 03 medical and health sciences, OVA, ovalbumin, mMCP5/Mcpt5, mouse mast cell protease 5, MOV, mean object volume, medicine, anaphylaxis, Animals, Fura-2 AM, Fura-2-acetoxymethyl ester, Qc-SNARE Proteins, Syt, synaptotagmin, Molecular Biology, 030102 biochemistry & molecular biology, SNAP23, synaptosomal-associated protein of 23 KDa, SCF, stem cell factor, Secretory Vesicles, RBL-2H3, rat basophilic leukemia cell line, Cell Biology, Cma1, chymase 1, allergy, Sv, surface density, VAMP, vesicle-associated membrane protein, 030104 developmental biology, B6, C57BL6/J mouse line, mast cell, Platelet factor 4, HSA, human serum albumin, Vv, volume density
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8204093fa71125dcdeede86da55ba3aeTest
http://europepmc.org/articles/PMC7948755Test -
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المؤلفون: Kiu Hyung Cho, Jae Gyu Park, Ebtesam M. Al-Olayan, Debasish Kumar Dey, Sukkum Ngullie Chang, Sun Chul Kang, Buyng Su Hwang, Seong Taek Oh, Won Ho Kong
المصدر: International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol 21, Iss 9261, p 9261 (2020)مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, nuclear factor kappa-light-chain-enhancer of activated b cells (NF-κb), phorbol 12-myristate 13-acetate (PMA), Antioxidants, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Onions, lcsh:QH301-705.5, Zebrafish, Spectroscopy, Cell Line, Transformed, chemistry.chemical_classification, Chemistry, NF-kappa B, allium cepa test, General Medicine, Computer Science Applications, 030220 oncology & carcinogenesis, Toxicity, Tetradecanoylphorbol Acetate, medicine.symptom, tangeretin (TAN), Signal Transduction, Embryonic Development, Inflammation, Article, Catalysis, Congenital Abnormalities, Inorganic Chemistry, 03 medical and health sciences, In vivo, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Reactive oxygen species, Organic Chemistry, NF-κB, hypoxia-inducible factor 1-alpha (HIF-1α), Flavones, Hypoxia-Inducible Factor 1, alpha Subunit, Molecular biology, In vitro, Oxidative Stress, HaCaT, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, zebrafish embryotoxicity test, inflammation, Phorbol, Lipid Peroxidation, Epidermis, Reactive Oxygen Species, Biomarkers
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339ddb89128337a6cd420d6bf7ee9633Test
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المؤلفون: Thorsten Maretzky, Stefan F. Lichtenthaler, Gisela Weskamp, Theresa T. Lu, Sebastien Monette, Jose Lora, Dorjee T.N. Shola, Chingwen Yang, Carl P. Blobel, Thomas M. Li
المصدر: The Journal of Biological Chemistry
The journal of biological chemistry 296, 100733-(2021). doi:10.1016/j.jbc.2021.100733مصطلحات موضوعية: 0301 basic medicine, Male, Cytoplasm, KI, knock-in, knock-in mutation in mice, Biochemistry, Mice, iRhom1 and 2, inactive Rhomboid proteins 1 and 2, ADAM17 Protein, membrane protein, myeloid cell, MFI, mean fluorescence intensity, Receptor, Sequence Deletion, TACE (TNFα converting enzyme), Bone growth, mEF, mouse embryonic fibroblast, Chemistry, Protein Stability, ddc, Cell biology, BMDM, bone-marrow-derived macrophage, TNFα, tumor necrosis factor α, Transmembrane domain, Phenotype, Protein destabilization, ddc:540, DV, donor vector, Female, Signal transduction, metabolism [Fibroblasts], Research Article, IL-6R, interleukin-6 receptor, PMA, phorbol 12-myristate 13-acetate, genetics [ADAM17 Protein], ADAM17 (a disintegrin and metalloprotease 17), 03 medical and health sciences, metabolism [ADAM17 Protein], cell surface enzyme, Protein Domains, CHX, cycloheximide, Gene knockin, Animals, Amino Acid Sequence, Molecular Biology, metabolism [Cytoplasm], 030102 biochemistry & molecular biology, Base Sequence, Cell Biology, chemistry [ADAM17 Protein], Sheddase, Fibroblasts, EGFR, epidermal growth factor receptor, Mice, Inbred C57BL, 030104 developmental biology, EPCAM, epithelial cell adhesion molecule, mES, mouse embryonic stem, CRISPR-Cas Systems, ADAM17, a disintegrin and metalloprotease 17
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ddba9cdef79f06d77f3f2a019dddabTest
https://pubmed.ncbi.nlm.nih.gov/33957124Test -
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المؤلفون: Yuh Lin Wu, Yen Yu Lin, David Sun
المصدر: Chinese Journal of Physiology, Vol 63, Iss 4, Pp 179-186 (2020)
مصطلحات موضوعية: 0301 basic medicine, endocrine system, akt, Physiology, protein phosphatase 2a, Wortmannin, 03 medical and health sciences, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Physiology (medical), QP1-981, Animals, Humans, Protein Phosphatase 2, Phosphorylation, Protein kinase B, Protein kinase C, PI3K/AKT/mTOR pathway, Inflammation, Granulosa Cells, Activator (genetics), Protein phosphatase 2, Okadaic acid, granulosa cell, Cell biology, Rats, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Female, Proto-Oncogene Proteins c-akt, phorbol 12-myristate 13-acetate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb15fb5ae51e583c8810aac0c9e043c2Test
https://pubmed.ncbi.nlm.nih.gov/32859885Test -
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المؤلفون: Akira Matsuura, Shunsuke Ishii, Rie Uesugi, Eisuke Itakura
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: mitochondrial sensor, PINK1, PTEN-induced putative kinase 1, TMD, transmembrane domain, Cellular homeostasis, Mitochondrion, Biochemistry, Parkin, chemistry.chemical_compound, Chlorocebus aethiops, Enzyme Stability, PTEN-induced putative kinase 1 (PINK1), Chemistry, Depolarization, TERT, telomerase reverse transcriptase, Mitochondria, Cell biology, COS Cells, OMM, outer mitochondrial membrane, RTK, receptor tyrosine kinase, mito-Pain F, mitochondrial PINK1 accumulation index (containing full-length PINK1), Research Article, PMA, phorbol 12-myristate 13-acetate, mito-Pain, mitochondrial PINK1 accumulation index, PINK1, Carbonyl cyanide m-chlorophenyl hydrazone, Fluorescence, CCCP, carbonyl cyanide m-chlorophenyl hydrazone, ER, endoplasmic reticulum, Mitochondrial Proteins, Small Molecule Libraries, mitochondrial membrane potential, ROS, reactive oxygen species, Stress, Physiological, Animals, Humans, DAPI, Molecular Biology, MTR, MitoTracker Red, Fluorescent Dyes, mitochondrial stress, KD, kinase dead, mito-Pain T, truncated mito-Pain, Cell Biology, Cytosol, HEK293 Cells, MTS, mitochondrial targeting sequence, Protein Kinases, DAPI, 4′,6-diamidino-2-phenylindole, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863dbecbc7c5145aaab80029becd9a14Test
https://doi.org/10.1016/j.jbc.2021.101279Test