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المؤلفون: Songsong Wang, Peng Li, Liang Zou, Jianbo Xiao, Feiya Sheng
المصدر: Journal of Advanced Research
مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, SREBPs, sterol regulatory element binding proteins, SREBP2, sterol regulatory element-binding protein 2, SHP, small heterodimer partner, chemistry.chemical_compound, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, LXRα, liver X receptor α, VLDL, very low-density lipoprotein, Multidisciplinary, TG, triglyceride, Bile acid, Chemistry, Fatty liver, FGF15/19, fibroblast growth factor 15/19, Cholesterol, WB, Western blot, ACC, Acetyl-CoA carboxylase, 030220 oncology & carcinogenesis, Lipogenesis, Quercetin, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, Bile acid metabolism, SDS, sodium dodecyl sulfate, TGR5, Takeda G-protein-coupled receptor 5, medicine.drug_class, Hyperoside, LC-MS, the combination of high-performance liquid chromatography and mass spectrometry, Article, Bile Acids and Salts, pACC, phosphorylated ACC, 03 medical and health sciences, Label-free proteomics, FXR, farnesoid X receptor, CYP27A1, sterol 27-hydroxylase, NAFLD, Internal medicine, medicine, Animals, Cholesterol metabolism, Liver X receptor, ComputingMethodologies_COMPUTERGRAPHICS, BAs, bile acids, SREBP1, sterol regulatory element-binding protein 1, Targeted metabolomics, Lipid Metabolism, CYP7A1, cholesterol 7α-hydroxylase, medicine.disease, Rats, TC, total cholesterol, QC, quality control, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, PMSF, phenylmethylsulfonyl fluoride, Apo, apolipoprotein, BSH, bile salt hydrolase, Farnesoid X receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2bd34a875a308c3012404fcb1667ccTest
https://doi.org/10.1016/j.jare.2021.06.001Test -
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المؤلفون: Teruo Miyazaki, Tadashi Ikegami, Satoru Takahashi, Junichi Iwamoto, Tadakuni Monma, Fumihiro Sugiyama, Akira Honda, Yukio Morishita, Seiya Mizuno, Takeshi Hirayama, Hajime Ueda
المصدر: Journal of Lipid Research, Vol 61, Iss 1, Pp 54-69 (2020)
J Lipid Resمصطلحات موضوعية: Male, 0301 basic medicine, Lithocholic acid, cytochrome P450, medicine.drug_class, QD415-436, 030204 cardiovascular system & hematology, Chenodeoxycholic Acid, Biochemistry, Bile Acids and Salts, Rats, Sprague-Dawley, CYP2A12, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Cytochrome P-450 Enzyme System, Chenodeoxycholic acid, 7α-hydroxy-4-cholesten-3-one 12α-hydroxylase, medicine, Animals, Research Articles, Mice, Knockout, Molecular Structure, cholesterol 7α-hydroxylase, Bile acid, Deoxycholic acid, Cholic acid, CYP2C70, Cell Biology, Molecular biology, Rats, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, chemistry, Steroid Hydroxylases, Knockout mouse, Small heterodimer partner, Female, Farnesoid X receptor, Aryl Hydrocarbon Hydroxylases, CRISPR-Cas9, Hydrophobic and Hydrophilic Interactions
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0208c867d823ecf4443ddb865a56abc8Test
https://doi.org/10.1194/jlr.ra119000395Test -
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المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100093-(2021)
Journal of Lipid Researchمصطلحات موضوعية: 0301 basic medicine, Very low-density lipoprotein, Hormone-sensitive lipase, 030204 cardiovascular system & hematology, Biochemistry, Carboxylesterase, Mice, SHP, small heterodimer partner, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, RCT, reverse cholesterol transport, cardiovascular disease, cholesteryl ester hydrolase, LKO, liver-specific Ces1d KO, Cells, Cultured, AADAC, arylacetamide deacetylase, Mice, Knockout, Western-type diet, Hydrolysis, Reverse cholesterol transport, WAT, white adipose tissue, lipase activity, WTD, Western-type diet, Cholesteryl ester, lipids (amino acids, peptides, and proteins), Cholesterol Esters, HSL, hormone-sensitive lipase, VLDL, Research Article, FC, free cholesterol, LD, lipid droplet, HDL, Mice, Transgenic, QD415-436, Cholesterol 7 alpha-hydroxylase, liver, SR-BI, scavenger receptor class B type I, 03 medical and health sciences, Hydrolase, Animals, Cholesterol, Cell Biology, CYP7A1, cholesterol 7α-hydroxylase, reverse cholesterol transport, TC, total cholesterol, Lox, Ces1dflox/flox, 030104 developmental biology, chemistry, 4-MU, 4-methylumbelliferone, cholesterol metabolism, Ces1d, carboxylesterase 1d
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c187170ad9e34930880af7dd91aa54Test
http://www.sciencedirect.com/science/article/pii/S0022227521000754Test -
4Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury
المؤلفون: Susanne N. Weber, Senem Ceren Karatayli, Grigorios Christidis, Ulrich Boehm, Matthias C. Reichert, Sen Qiao, Ersin Karatayli, Mathias Hohl, Frank Lammert, Dieter Lütjohann, Rabea A. Hall
المصدر: International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 7898, p 7898 (2021)مصطلحات موضوعية: Male, 0301 basic medicine, FGF21, Receptors, Cytoplasmic and Nuclear, Mice, acute-on-chronic liver failure (ACLF), 0302 clinical medicine, cholesterol 7α-hydroxylase (Cyp7A1), Biology (General), Cholesterol 7-alpha-Hydroxylase, Spectroscopy, Mice, Knockout, fibroblast growth factor 21 (FGF21), Bile acid, Chemistry, alcohol-associated liver disease (AALD), General Medicine, Computer Science Applications, Small heterodimer partner, Female, 030211 gastroenterology & hepatology, medicine.medical_specialty, ATP Binding Cassette Transporter, Subfamily B, QH301-705.5, medicine.drug_class, Cholesterol 7 alpha-hydroxylase, Article, Catalysis, Bile Acids and Salts, Inorganic Chemistry, 03 medical and health sciences, Internal medicine, medicine, Animals, bile acid, Physical and Theoretical Chemistry, QD1-999, Molecular Biology, ATP binding cassette subfamily B member 4 (Abcb4) knock-out mouse, Fibroblast growth factor receptor 1, FGF15, Organic Chemistry, Acute-On-Chronic Liver Failure, FGF19, Fibroblast growth factor receptor 4, Fibroblast Growth Factors, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Case-Control Studies, Hepatocytes
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3c43ea2a974960e0e9629d04ec5af6Test
https://doi.org/10.3390/ijms22157898Test -
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المؤلفون: Julia Yue Cui, Curtis D. Klaassen, Zidong Donna Fu
المصدر: Journal of Lipid Research, Vol 55, Iss 12, Pp 2576-2586 (2014)
مصطلحات موضوعية: Male, Atorvastatin, Organic Anion Transporters, Sodium-Independent, Biochemistry, chemistry.chemical_compound, Endocrinology, Enterohepatic Circulation, ATP Binding Cassette Transporter, Subfamily G, Member 5, Intestinal Mucosa, Cholesterol 7-alpha-Hydroxylase, Enterohepatic circulation, Research Articles, Cytochrome P-450 Enzyme Inducers, Symporters, Bile acid, Liver-Specific Organic Anion Transporter 1, RNA-Binding Proteins, Organic anion-transporting polypeptide, Liver, Small heterodimer partner, Cholestanetriol 26-Monooxygenase, lipids (amino acids, peptides, and proteins), Signal Transduction, medicine.drug, medicine.medical_specialty, medicine.drug_class, Lipoproteins, ultra-performance liquid chromatography-tandem mass spectrometry, Organic Anion Transporters, Sodium-Dependent, QD415-436, Biology, Cholesterol 7 alpha-hydroxylase, Bile Acids and Salts, Ileum, Internal medicine, medicine, Animals, Humans, Pyrroles, cardiovascular diseases, farnesoid X receptor signaling, cholesterol 7α-hydroxylase, Cholesterol, ATP Binding Cassette Transporter, Subfamily G, Member 8, nutritional and metabolic diseases, Cell Biology, Mice, Inbred C57BL, chemistry, Heptanoic Acids, biology.protein, ATP-Binding Cassette Transporters, Farnesoid X receptor, Hydroxymethylglutaryl-CoA Reductase Inhibitors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f603eafd77213a6e62859a2c96799Test
https://doi.org/10.1194/jlr.m053124Test -
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المؤلفون: Marco Montagnani, Elisa Michelini, Antonella Marangoni, Rita Aldini, Claudio Foschi, Luca Cevenini, Roberto Cevenini, Manuela Donati, Aldo Roda, Ido Ben Zvi, Laura Mezzanotte, Paola Nardini, Monica Cevenini
المساهمون: Michelini E, Donati M, Aldini R, Cevenini L, Mezzanotte L, Nardini P, Foschi C, Zvi IB, Cevenini M, Montagnani M, Marangoni A, Roda A, Cevenini R.
المصدر: Analytical Biochemistry. 430:92-96
مصطلحات موضوعية: Blood Glucose, Male, Human cytomegalovirus, Transcription, Genetic, Biophysics, Color, Cytomegalovirus, Biology, Cholesterol 7 alpha-hydroxylase, Biochemistry, Microbiology, Proinflammatory cytokine, Mice, chemistry.chemical_compound, Multiplicity of infection, Chlamydia pneumoniae, medicine, Cholesterol 7α-hydroxylase, Animals, Humans, Viability assay, Cholesterol 7-alpha-Hydroxylase, Chlamydophila Infections, Molecular Biology, Triglycerides, Mice, Inbred BALB C, Cholesterol, Cholesterol, HDL, Hep G2 Cells, Cell Biology, Chlamydophila pneumoniae, medicine.disease, Virology, chemistry, Cell culture, Luminescent Measurements, Cell-based assay, Bioluminescent, lipids (amino acids, peptides, and proteins), Lipoprotein
وصف الملف: STAMPA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0671af8a3408bec77c21be9a076316dcTest
https://doi.org/10.1016/j.ab.2012.08.003Test -
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المؤلفون: Emmett O’Flaherty, Eleanor Davies, Alison D. McNeilly, Ole Skøtt, Dawn E W Livingstone, Tijana Mitić, Ruth Andrew, David P. Macfarlane, Rebecca M. Reynolds, Brian R. Walker, Scott M. McKenzie, Helle C. Thiesson, Kirsty M.M. McConnell
المصدر: McNeilly, A D, Macfarlane, D P, O'Flaherty, E, Livingstone, D E, Mitić, T, McConnell, K M, McKenzie, S M, Davies, E, Reynolds, R M, Thiesson, H C, Skøtt, O, Walker, B R & Andrew, R 2010, ' Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice ', Journal of Hepatology, vol. 52, no. 5, pp. 705-11 . https://doi.org/10.1016/j.jhep.2009.10.037Test
Journal of Hepatology
ResearcherID
McNeilly, A D, Macfarlane, D P, O'Flaherty, E, Livingstone, D E, Mitić, T, McConnell, K M, McKenzie, S M, Davies, E, Reynolds, R M, Thiesson, H C, Skøtt, O, Walker, B R & Andrew, R 2010, ' Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice ', Journal of Hepatology, vol. 52, no. 5, pp. 705-711 . https://doi.org/10.1016/j.jhep.2009.10.037Testمصطلحات موضوعية: Male, Hydrocortisone, Transcription, Genetic, Pituitary-Adrenal System, GCDCA, glyco-CDCA, DMEM, Dulbecco’s modified Eagle’s medium, chemistry.chemical_compound, PCR, polymerase chain reaction, Glucocorticoid, Cytosol, 0302 clinical medicine, GCMS, gas chromatography mass spectrometry, Chenodeoxycholic acid, DHB, dihydrocorticosterone, Adrenal, Promoter Regions, Genetic, Ki, inhibitor constant, Tetrahydrocortisol, ANOVA, analysis of variance, CA, cholic acid, 0303 health sciences, Bile acid, Deoxycholic acid, HPA, hypothalamic–pituitary–adrenal, SEM, standard error of mean, 3. Good health, Jaundice, Obstructive, ECRP, endoscopic retrograde cholangiopancreatography, Liver, 030220 oncology & carcinogenesis, ACTH, adrenocorticotropic hormone, Female, TCDCA, tauro-CDCA, Research Article, medicine.drug, THB, tetrahydrocorticosterone, Hypothalamo-Hypophyseal System, medicine.medical_specialty, 3αHSD, 3α-hydroxysteroid dehydrogenase, 3-Hydroxysteroid Dehydrogenases, ALT, alanine transaminase, medicine.drug_class, Jaundice, BDL, bile duct ligation, Biology, Cholesterol 7 alpha-hydroxylase, Cyp11b1, 11β-hydroxylase, CDCA, chenodeoxycholic acid, Bile Acids and Salts, 03 medical and health sciences, FXR, farnesoid X receptor, Cholestasis, Internal medicine, NEFA, non-esterified fatty acids, medicine, Animals, Humans, 5β-reductase, Rats, Wistar, Glucocorticoids, Ligation, 030304 developmental biology, Cyp7a1, cholesterol 7α-hydroxylase, ALP, alkaline phosphatase, Base Sequence, Hepatology, Cholic acid, medicine.disease, Rats, FF, fat-free, Kinetics, Endocrinology, 11βHSD, 11β-hydroxysteroid dehydrogenase, DCA, deoxycholic acid, chemistry, Farnesoid X receptor, Bile Ducts
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e698cd184636708be102d796e53ff053Test
https://doi.org/10.1016/j.jhep.2009.10.037Test -
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المؤلفون: Stephen J. Gardell, Mark J. Evans, Chris Petucci, Shuguang Wang, Julie A. Krueger, Helen B. Hartman
المصدر: Journal of Lipid Research, Vol 50, Iss 6, Pp 1090-1100 (2009)
مصطلحات موضوعية: Male, Apolipoprotein E, medicine.medical_specialty, Indoles, medicine.drug_class, Gene Expression, Receptors, Cytoplasmic and Nuclear, QD415-436, Biology, Cholesterol 7 alpha-hydroxylase, Biochemistry, Bile Acids and Salts, Mice, chemistry.chemical_compound, Apolipoproteins E, small heterodimer partner, Endocrinology, Internal medicine, medicine, Animals, sterol 12 α-hydroxylase, Steroid 12-alpha-Hydroxylase, Cholesterol 7-alpha-Hydroxylase, Dyslipidemias, Mice, Knockout, cholesterol 7α-hydroxylase, Bile acid, Cholesterol, Azepines, Cell Biology, Lipids, Mice, Inbred C57BL, Receptors, LDL, chemistry, LDL receptor, Small heterodimer partner, Female, lipids (amino acids, peptides, and proteins), Farnesoid X receptor, atherosclerosis, CYP8B1, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78eeed91ed4e5c856d4dbfc2c80d0f0Test
https://doi.org/10.1194/jlr.m800619-jlr200Test -
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المؤلفون: Paolo Parini, Charlotte Murphy, Ingemar Björkhem, Mats Gåfvels, Jin Wang, Curt Einarsson, Gösta Eggertsen
المصدر: Journal of Lipid Research, Vol 47, Iss 2, Pp 421-430 (2006)
مصطلحات موضوعية: Male, Gene Expression, Receptors, Cytoplasmic and Nuclear, Biochemistry, Cholesterol, Dietary, Feces, Mice, chemistry.chemical_compound, Endocrinology, Bile, Homeostasis, ATP Binding Cassette Transporter, Subfamily G, Member 5, Cholesterol 7-alpha-Hydroxylase, ATP Binding Cassette Transporter, Subfamily B, Member 11, Liver X Receptors, Mice, Knockout, biology, Chemistry, Reverse cholesterol transport, Orphan Nuclear Receptors, Lipids, DNA-Binding Proteins, Cholesterol, Liver, Female, lipids (amino acids, peptides, and proteins), Sterol Regulatory Element Binding Protein 1, ATP Binding Cassette Transporter 1, Sterol Regulatory Element Binding Protein 2, liver X receptor, medicine.medical_specialty, ATP Binding Cassette Transporter, Subfamily B, Lipoproteins, Cholic Acid, QD415-436, Cholesterol 7 alpha-hydroxylase, sterol 12α-hydroxylase, Bile Acids and Salts, Internal medicine, medicine, Animals, Steroid 12-alpha-Hydroxylase, Liver X receptor, bile acids, Apolipoprotein A-I, cholesterol 7α-hydroxylase, ATP Binding Cassette Transporter, Subfamily G, Member 8, Cholic acid, Isoxazoles, Cell Biology, ABCA1, biology.protein, ATP-Binding Cassette Transporters, Hydroxymethylglutaryl CoA Reductases, Farnesoid X receptor, CYP8B1, farnesoid X receptor, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313f09a198d7bd694dda272a663bb055Test
https://doi.org/10.1194/jlr.m500441-jlr200Test -
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المؤلفون: William M. Pandak, Dalila Marques, Shunlin Ren, Elizabeth Hall, Kaye Redford, Gregorio Gil, Phillip B. Hylemon
المصدر: Journal of Lipid Research, Vol 45, Iss 11, Pp 2123-2131 (2004)
مصطلحات موضوعية: Male, Time Factors, medicine.drug_class, Blotting, Western, QD415-436, sterol carrier protein-2, Biology, Intracellular cholesterol transport, Cholesterol 7 alpha-hydroxylase, Models, Biological, Biochemistry, Adenoviridae, Bile Acids and Salts, Rats, Sprague-Dawley, Endocrinology, CYP27A1, medicine, Animals, Humans, sterol 27-hydroxylase, Cholesterol 7-alpha-Hydroxylase, Cells, Cultured, cholesterol 7α-hydroxylase, Bile acid, Steroidogenic acute regulatory protein, Membrane Transport Proteins, Biological Transport, MLN64, Cell Biology, Phosphoproteins, G protein-coupled bile acid receptor, Sterol, Rats, Up-Regulation, Cholesterol, Steroid Hydroxylases, Hepatocytes, Cholestanetriol 26-Monooxygenase, Carrier Proteins, CYP8B1, metabolism, steroidogenic acute regulatory protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d7423d6c68542d9a0b2a502873646fTest
https://doi.org/10.1194/jlr.m400233-jlr200Test