المؤلفون: Chin Wong, Thomas Gelzleichter, Junichiro Sonoda, Amos Baruch, Linda Morrow, Suresh Dheerendra, Leslie W. Chinn, Richard Boismenu, Eric Wakshull, Maria E. Wilson, Puneet S. Arora, Shan Chen, Anjali Vaze, Johnny Gutierrez, Nicholas Lewin-Koh

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Male, 0301 basic medicine, obesity, Medical Sciences, FGF21, Adipose tissue, Mice, 0302 clinical medicine, Weight loss, Homeostasis, Medicine, Multidisciplinary, biology, Middle Aged, Biological Sciences, Adipose Tissue, Female, Adiponectin, Antibody, medicine.symptom, FGF21 receptor activation, Adult, Agonist, medicine.medical_specialty, Adolescent, medicine.drug_class, 030209 endocrinology & metabolism, Antibodies, Food Preferences, Young Adult, 03 medical and health sciences, Internal medicine, Weight Loss, Animals, Humans, Receptor, Fibroblast Growth Factor, Type 1, Aged, business.industry, Fibroblast growth factor receptor 1, Body Weight, medicine.disease, Obesity, Fibroblast Growth Factors, stomatognathic diseases, Macaca fascicularis, 030104 developmental biology, Endocrinology, biology.protein, food preference, business, metabolism, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb1e6fc5999a3fd66bc3ad16e368b18Test
https://doi.org/10.1073/pnas.2012073117Test

المؤلفون: Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini

المصدر: Journal of medicinal chemistry. 64(16)

مصطلحات موضوعية: Phases of clinical research, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Mice, Structure-Activity Relationship, Breast cancer, Dogs, In vivo, Drug Discovery, medicine, Animals, Humans, Dosing, Molecular Structure, Chemistry, Antagonist, Estrogen Receptor alpha, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Rats, Macaca fascicularis, Cell culture, Cancer research, MCF-7 Cells, Molecular Medicine, Female, Estrogen Receptor Antagonists, Carbolines

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee86fe3f8068fbb2ff9647a59eadb710Test
https://pubmed.ncbi.nlm.nih.gov/34251202Test

المؤلفون: Sharmila Rajan, Thomas Gelzleichter, Amos Baruch, Junichiro Sonoda, C. Andrew Boswell, Dale Stevens, Eric Stefanich, Danielle Mandikian, Kyra J. Cowan

المصدر: mAbs. 9:1379-1388

مصطلحات موضوعية: Male, 0301 basic medicine, Receptor complex, FGF21, medicine.drug_class, Receptor expression, Immunology, Drug Evaluation, Preclinical, Adipose tissue, CHO Cells, Pharmacology, Biology, Diet, High-Fat, Monoclonal antibody, 03 medical and health sciences, Cricetulus, Report, Cricetinae, medicine, Animals, Immunology and Allergy, Tissue Distribution, Obesity, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Adiponectin, Fibroblast growth factor receptor 1, Antibodies, Monoclonal, Fibroblast Growth Factors, Mice, Inbred C57BL, Macaca fascicularis, 030104 developmental biology, Adipose Tissue, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe09bafc48ef65e54437fd42a8236afTest
https://doi.org/10.1080/19420862.2017.1373923Test

المؤلفون: Gerhard F. Weinbauer, Akihiro Arima, Chris Schuetz, Cynthia Woods, Hong Wang, Jane L. Grogan, Thomas Gelzleichter, Yutaka Chihaya, Gary Cain, Gunnar Habermann, Jim Xiao

المصدر: Reproductive Toxicology. 63:82-95

مصطلحات موضوعية: Male, 0301 basic medicine, Lymphocyte, Embryonic Development, Lymphocytosis, Antibodies, Monoclonal, Humanized, Toxicology, Immunoglobulin G, Fetal Development, Andrology, 03 medical and health sciences, Pregnancy, medicine, Animals, Mesenteric lymph nodes, Lymphotoxin-alpha, Maternal-Fetal Exchange, Lymph node, Pateclizumab, Fetus, biology, Embryo, Mammalian, Macaca fascicularis, 030104 developmental biology, medicine.anatomical_structure, Immunology, biology.protein, Female, Lymph Nodes, Lymph, Antibody, Dendritic Cells, Follicular

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a2e69ba3906a3b5f46dd8a6489dc72Test
https://doi.org/10.1016/j.reprotox.2016.05.014Test

المؤلفون: Susan L. Limb, Lin Pan, Linda Nguyen, Yuan Chen, Thomas Gelzleichter, Cindy Burg

المصدر: Pulmonary pharmacologytherapeutics. 51

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Time Factors, Pyridones, Cmax, Administration, Oral, 030204 cardiovascular system & hematology, Gastroenterology, Drug Administration Schedule, Rats, Sprague-Dawley, 03 medical and health sciences, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Pharmacokinetics, Oral administration, Internal medicine, medicine, Animals, Pharmacology (medical), Gastric emptying, business.industry, Stomach, digestive, oral, and skin physiology, Biochemistry (medical), Anti-Inflammatory Agents, Non-Steroidal, Pirfenidone, medicine.disease, Rats, medicine.anatomical_structure, 030228 respiratory system, Tolerability, Gastric Emptying, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fadbac9bf93b56c393cf4fd4780449Test
https://pubmed.ncbi.nlm.nih.gov/29944949Test

المؤلفون: Kyra J. Cowan, Feng Yang, Mark Z. Chen, Ambrose Williams, Terry Hudson, Shannon Liu, Nicole Valle, Timothy Tully, Junichiro Sonoda, Thomas Gelzleichter, Sharmila Rajan, Frank Macchi

المصدر: Journal of pharmacological and toxicological methods. 94(Pt 1)

مصطلحات موضوعية: 0301 basic medicine, Male, Bispecific antibody, Receptor complex, Mice, Obese, CHO Cells, Toxicology, Antibodies, Cell Line, 03 medical and health sciences, Mice, Cricetulus, Animals, Humans, Obesity, Receptor, Fibroblast Growth Factor, Type 1, Related impurities, Obese Mice, Pharmacology, Manufacturing process, Chemistry, Membrane Proteins, Highly selective, Combinatorial chemistry, Mice, Inbred C57BL, Molecular Weight, stomatognathic diseases, Disease Models, Animal, Drug Combinations, 030104 developmental biology, HEK293 Cells, Product (mathematics), Immunoglobulin G, Drug product, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b66987db00744fc1e7acdc79bb85f9Test
https://pubmed.ncbi.nlm.nih.gov/29660397Test

المؤلفون: Diana Ronai Dunshee, Jose Zavala-Solorio, Hok Seon Kim, Sharmila Rajan, Yongmei Chen, James A. Ernst, Elizabeth Luis, Ai-Luen Wu, Robert Soriano, Ganesh Kolumam, Amos Baruch, Mark Z. Chen, Raymond K. Tong, Shelby K. Wyatt, Richard A.D. Carano, Christoph Spiess, Owen P. McGuinness, Jean-Michel Vernes, Andrew S. Peterson, Søren Warming, Keith R. Anderson, Xin Y. Rairdan, Junichiro Sonoda, Matthew J. Brauer, Scott Stawicki, Benjamin Haley, Laetitia Comps-Agrar, Jed Ross, Y. Gloria Meng, Johnny Gutierrez, James Ziai, Thomas Gelzleichter, Travis W. Bainbridge, Nicholas Lewin-Koh, Yan Wu, Nicholas van Bruggen, Vineela D. Gandham, Lance Kates, Yingnan Zhang, Dale Stevens

المصدر: EBioMedicine, Vol 2, Iss 7, Pp 730-743 (2015)
EBioMedicine

مصطلحات موضوعية: Male, FGF21, medicine.medical_treatment, Bispecific antibody, Adipose tissue, Mice, Obese, lcsh:Medicine, White adipose tissue, Brown adipose tissue, FGF19, Therapeutic antibody, Adipose Tissue, Brown, Antibodies, Bispecific, Insulin, Mice, Inbred BALB C, lcsh:R5-920, NASH, Thermogenesis, Type 2 diabetes, General Medicine, medicine.anatomical_structure, Original Article, Adipose tissue browning, Adiponectin, lcsh:Medicine (General), Protein Binding, medicine.medical_specialty, UCP1, Humanized antibody, Biology, General Biochemistry, Genetics and Molecular Biology, Cell Line, Insulin resistance, Internal medicine, Weight Loss, medicine, Animals, Humans, betaKlotho, Receptor, Fibroblast Growth Factor, Type 1, Obesity, Klotho Proteins, Fibroblast growth factor receptor 1, lcsh:R, Membrane Proteins, Hepatosteatosis, medicine.disease, Fibroblast Growth Factors, Mice, Inbred C57BL, Macaca fascicularis, Endocrinology, HEK293 Cells, FGFR1, Energy Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292cc2ae94284197f1952ee9ad725380Test
http://www.sciencedirect.com/science/article/pii/S235239641530030XTest

المؤلفون: Helen G. Haggerty, Matthew S. Holdren, R. Daniel Mellon, Rafael Ponce, Herve Lebrec, Shawn Heidel, Thomas Gelzleichter, Marc Pallardy

المصدر: Journal of Immunotoxicology. 11:1-12

مصطلحات موضوعية: Epstein-Barr Virus Infections, Herpesvirus 4, Human, Lymphoma, B-Cell, medicine.medical_treatment, Immunology, Inflammation, Biology, Toxicology, Risk Assessment, Metastasis, Immunomodulation, Immunocompromised Host, Immune system, medicine, Animals, Humans, B-Lymphocytes, Cancer, Immunosuppression, medicine.disease, Lymphoma, Immunosurveillance, Cell Transformation, Neoplastic, Immunotherapy, medicine.symptom, Oncovirus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb931be0464fece0d57d180d92f97bffTest
https://doi.org/10.3109/1547691x.2013.798388Test

المؤلفون: Curtis Maier, James Green, Holly W. Smith, Dan Wierda, Gopi Shankar, Danuta J. Herzyk, Inge A. Ivens, Shalini Gupta, Leslie Abad, Lakshmi Amaravadi, Bonita Rup, Thomas Gelzleichter, Peter Thomas, Christopher Hurst, Rafael A. Ponce, Elizabeth R. Gore, Thomas T. Kawabata, Barbara Mounho

المصدر: Regulatory Toxicology and Pharmacology. 54:164-182

مصطلحات موضوعية: Dose-Response Relationship, Drug, business.industry, Drug Administration Routes, Immunogenicity, Drug Evaluation, Preclinical, Data interpretation, Nonclinical safety, General Medicine, Pharmacology, Toxicology, Bioinformatics, Drug Administration Schedule, Recombinant Proteins, Biopharmaceutics, Species Specificity, Data Interpretation, Statistical, Antibody Formation, Toxicity Tests, Animals, Humans, Medicine, business, Toxicity profile, Clinical evaluation, Antibody formation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db21763a3b63644b6a26f232396a111Test
https://doi.org/10.1016/j.yrtph.2009.03.012Test

المؤلفون: Suhasini Iyer, Sherry Yeh, Kathy Howell, Mercedesz Balazs, Laura DeForge, Jeffrey Thompson, Allen J. Ebens, Zhonghua Lin, Christine Ambrose, Maya Leabman, Germaine Fuh, Shiming Ye, Wyne P. Lee, Qinglin Ou, Thomas Gelzleichter, Chingwei V. Lee, Wei Yu Lin, Dimitry M. Danilenko, Melissa A. Starovasnik, Joseph Beyer, Qian Gong, Dhaya Seshasayee, Flavius Martin, Jean Shu, Eric Suto

المصدر: Blood. 110:3959-3967

مصطلحات موضوعية: Cell Survival, medicine.drug_class, medicine.medical_treatment, Plasma Cells, Immunology, Bone Marrow Cells, Monoclonal antibody, Biochemistry, Lymphocyte Depletion, Mice, Species Specificity, Antigen, Neoplasms, B-Cell Activating Factor, Animals, Medicine, B-cell activating factor, B cell, CD20, Mice, Inbred BALB C, biology, business.industry, Antibodies, Monoclonal, Cell Biology, Hematology, Immunotherapy, Blockade, Macaca fascicularis, medicine.anatomical_structure, Immune System Diseases, biology.protein, Antibody, business, B-Cell Activation Factor Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097d141204a369c61e0bbe2e44212d6aTest
https://doi.org/10.1182/blood-2007-04-088088Test