المساهمون: Sang Hoon Lee, Eun Young Kim, Jung Min Han, Gyoonhee Han, Yoon Soo Chang, Kim, Eun Young

مصطلحات موضوعية: Amino Acids / pharmacology, Amino Acids / therapeutic use, Animals, Carcinoma, Non-Small-Cell Lung* / drug therapy, Non-Small-Cell Lung* / genetics, Non-Small-Cell Lung* / pathology, Cell Line, Tumor, Cell Proliferation, Humans, Lung Neoplasms* / drug therapy, Lung Neoplasms* / genetics, Lung Neoplasms* / pathology, Mammals / metabolism, Mechanistic Target of Rapamycin Complex 1 / metabolism, Mechanistic Target of Rapamycin Complex 1 / pharmacology, Mice, Mitogen-Activated Protein Kinase Kinases / pharmacology, Mitogen-Activated Protein Kinase Kinases / therapeutic use, Protein Kinase Inhibitors / therapeutic use, BC-LI-0186, LARS1, Non-small cell lung cancer, Trametinib, mTORC1

العلاقة: CANCER RESEARCH AND TREATMENT; J00453; OAK-2023-02139; OAK-2023-02140; OAK-2023-02141; https://ir.ymlib.yonsei.ac.kr/handle/22282913/195578Test; T202303868; CANCER RESEARCH AND TREATMENT, Vol.55(3) : 851-864, 2023-06

الإتاحة: https://doi.org/10.4143/crt.2022.1527Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195578Test

المساهمون: SeongShick Ryu, Yunju Nam, Namkyoung Kim, Injae Shin, Eunhye Jeon, Younghoon Kim, Nam Doo Kim, Taebo Sim, Sim, Taebo

مصطلحات موضوعية: Animals, Antineoplastic Agents* / pharmacology, Antineoplastic Agents* / therapeutic use, Apoptosis, Cell Line, Tumor, Cell Proliferation, Drug Resistance, Humans, Mice, Protein Kinase Inhibitors* / pharmacology, Protein Kinase Inhibitors* / therapeutic use, Signal Transduction

العلاقة: JOURNAL OF MEDICINAL CHEMISTRY; J01588; OAK-2022-02353; https://ir.ymlib.yonsei.ac.kr/handle/22282913/188578Test; T202201511; JOURNAL OF MEDICINAL CHEMISTRY, Vol.65(8) : 6017-6038, 2022-04

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01776Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188578Test

المساهمون: Magda Bahcall, Cloud P Paweletz, Yanan Kuang, Luke J Taus, Taebo Sim, Nam Doo Kim, Kshiti H Dholakia, Christie J Lau, Prafulla C Gokhale, Pratik R Chopade, Fangxin Hong, Zihan Wei, Jens Köhler, Paul T Kirschmeier, Jiannan Guo, Sujuan Guo, Stephen Wang, Pasi A Jänne, Sim, Taebo

مصطلحات موضوعية: Animals, Drug Resistance, Neoplasm / drug effects, Female, High-Throughput Nucleotide Sequencing / methods, Humans, Mice, Molecular Docking Simulation / methods, Protein Kinase Inhibitors / pharmacology, Protein Kinase Inhibitors / therapeutic use

العلاقة: MOLECULAR CANCER THERAPEUTICS; J02254; OAK-2022-02281; https://ir.ymlib.yonsei.ac.kr/handle/22282913/188552Test; https://aacrjournals.org/mct/article/21/2/322/678522/Combination-of-Type-I-and-Type-II-MET-TyrosineTest; T202201478; MOLECULAR CANCER THERAPEUTICS, Vol.21(2) : 322-335, 2022-02

الإتاحة: https://doi.org/10.1158/1535-7163.MCT-21-0344Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188552Test
https://aacrjournals.org/mct/article/21/2/322/678522/Combination-of-Type-I-and-Type-II-MET-TyrosineTest

المؤلفون: Yu, Mengdi, Zhang, Hongxia, Wang, Brian, Zhang, Yinuo, Zheng, Xiaoying, Shao, Bei, Zhuge, Qichuan, Jin, Kunlin

المصدر: Cells

مصطلحات موضوعية: metabolism, ampk, sirt1, aging, health span, intervention, mTOR, senescence, signaling, AMP-Activated Protein Kinases / metabolism, Age Factors, Animals, Biomarkers / metabolism, Cognition / drug effects, Cognitive Aging, Enzyme Activation, Enzyme Activators / therapeutic use, Functional Status, Healthy Aging / drug effects, Healthy Aging / metabolism, Healthy Aging / psychology, Humans, Mental Health, Molecular Targeted Therapy, Protein Kinase Inhibitors / therapeutic use, Signal Transduction / drug effects, Sirtuin 1 / metabolism, TOR Serine-Threonine Kinases / antagonists & inhibitors, TOR Serine-Threonine Kinases / metabolism

وصف الملف: application/pdf

العلاقة: https://doi.org/10.3390/cells10030660Test; Yu, M., Zhang, H., Wang, B., Zhang, Y., Zheng, X., Shao, B., Zhuge, Q., & Jin, K. (2021). Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging. Cells, 10(3), 660. https://doi.org/10.3390/cells10030660Test; https://hdl.handle.net/20.500.12503/31700Test; 10

الإتاحة: https://doi.org/20.500.12503/31700Test
https://doi.org/10.3390/cells10030660Test
https://hdl.handle.net/20.500.12503/31700Test

المؤلفون: Chen, Ching-Hsien, Statt, Sarah, Chiu, Chun-Lung, Thai, Philip, Arif, Muhammad, Adler, Kenneth B, Wu, Reen

المصدر: American journal of respiratory and critical care medicine. 190(10)

مصطلحات موضوعية: Animals, Cell Culture Techniques, Cell Line, Tumor, Disease Models, Animal, Humans, Intracellular Signaling Peptides and Proteins: metabolism, Lung Neoplasms: drug therapy, metabolism, pathology, Membrane Proteins: metabolism, Mice, Phosphatidylinositol 3-Kinase: metabolism, Phosphatidylinositol Phosphates: metabolism, Phosphorylation: physiology, Protein Kinase Inhibitors: therapeutic use, Quinazolines: therapeutic use, Signal Transduction: physiology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7jm9t4vvTest

المساهمون: Hanna Cho, Injae Shin, Hojong Yoon, Eunhye Jeon, Jiwon Lee, Younghoon Kim, SeongShick Ryu, Chiman Song, Nam Hoon Kwon, Youngji Moon, Sunghoon Kim, Nam Doo Kim, Hwan Geun Choi, Taebo Sim, Sim, Taebo

مصطلحات موضوعية: Animals, Antineoplastic Agents / chemical synthesis, Antineoplastic Agents / metabolism, Antineoplastic Agents / pharmacology, Antineoplastic Agents / therapeutic use, Cell Line, Tumor, Drug Screening Assays, Antitumor, Female, Focal Adhesion Kinase 1 / antagonists & inhibitors, Focal Adhesion Kinase 1 / metabolism, Humans, Mice, Inbred BALB C, Nude, Molecular Docking Simulation, Molecular Structure, Neoplasm Metastasis / prevention & control, Neoplasms / drug therapy, Phosphorylation / drug effects, Protein Kinase Inhibitors / chemical synthesis, Protein Kinase Inhibitors / metabolism, Protein Kinase Inhibitors / pharmacology, Protein Kinase Inhibitors / therapeutic use, Pyrimidines / chemical synthesis, Pyrimidines / metabolism, Pyrimidines / pharmacology, Pyrimidines / therapeutic use, Structure-Activity Relationship

العلاقة: JOURNAL OF MEDICINAL CHEMISTRY; J01588; OAK-2021-08342; https://ir.ymlib.yonsei.ac.kr/handle/22282913/187089Test; T202105027; JOURNAL OF MEDICINAL CHEMISTRY, Vol.64(16) : 11934-11957, 2021-07

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00459Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187089Test

المؤلفون: Van Etten, Richard A, Mauro, Michael, Radich, Jerald P, Goldman, John M, Saglio, Giuseppe, Jamieson, Catriona, Soverini, Simona, Gambacorti-Passerini, Carlo, Hehlmann, Rüdiger, Martinelli, Giovanni, Perrotti, Danilo, Scadden, David T, Skorski, Tomasz, Tefferi, Ayalew, Mughal, Tariq I

المصدر: Leukemia & lymphoma. 54(6)

مصطلحات موضوعية: Animals, Antineoplastic Agents: therapeutic use, Genomics, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive: etiology, therapy, Molecular Targeted Therapy, Neoplastic Stem Cells: metabolism, Protein Kinase Inhibitors: therapeutic use, Stem Cell Niche, Treatment Outcome

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9306b9vdTest

المؤلفون: Ahmed, Wesam, Van Etten, Richard A

المصدر: Current hematologic malignancy reports. 8(1)

مصطلحات موضوعية: Animals, Antineoplastic Agents: therapeutic use, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive: drug therapy, metabolism, Molecular Targeted Therapy: methods, Neoplasm Proteins: metabolism, Protein Kinase Inhibitors: therapeutic use, Signal Transduction: drug effects

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/53r0c1hrTest

المؤلفون: Friedlaender, Alex, Addeo, Alfredo, Russo, Alessandro, Gregorc, Vanesa, Cortinovis, Diego, Rolfo, Christian D

المصدر: ISSN: 1422-0067 ; International journal of molecular sciences, vol. 21, no. 17 (2020) 6329.

مصطلحات موضوعية: info:eu-repo/classification/ddc/616, ALK, EGFR, NSCLC, Early stage, Osimertinib, Targeted therapy, Animals, Carcinoma, Non-Small-Cell Lung / drug therapy, Non-Small-Cell Lung / metabolism, Non-Small-Cell Lung / pathology, Humans, Lung Neoplasms / drug therapy, Lung Neoplasms / metabolism, Lung Neoplasms / pathology, Molecular Targeted Therapy, Neoplasm Proteins / antagonists & inhibitors, Protein Kinase Inhibitors / therapeutic use

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32878298; https://archive-ouverte.unige.ch/unige:171929Test; unige:171929

الإتاحة: https://doi.org/10.3390/ijms21176329Test
https://archive-ouverte.unige.ch/unige:171929Test

المؤلفون: Zaleskas, Virginia M, Krause, Daniela S, Lazarides, Katherine, Patel, Nihal, Hu, Yiguo, Li, Shaoguang, Van Etten, Richard A

المصدر: PloS one. 1

مصطلحات موضوعية: Amino Acid Substitution, Animals, Bone Marrow Transplantation, Disease Models, Animal, Enzyme Activation, Erythropoiesis, Humans, Janus Kinase 2: antagonists & inhibitors, genetics, metabolism, Leukocytosis: blood, etiology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Platelet Count, Point Mutation, Polycythemia Vera: blood, drug therapy, enzymology, genetics, Primary Myelofibrosis: etiology, pathology, Protein Kinase Inhibitors: therapeutic use, Recombinant Proteins: genetics, metabolism, Transduction, Genetic

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/32n8720pTest