المؤلفون: Hans-Peter Hammes, Elena Heidenreich, Peter P. Nawroth, Martina U. Muckenthaler, Sandro Altamura, Thomas Fleming, Andrea Schlotterer, Katja Müdder, Ruiyue Qiu

المصدر: Molecular Metabolism, Vol 51, Iss, Pp 101235-(2021)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, DR, diabetic retinopathy, Hepcidin, medicine.disease_cause, Mice, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, MetS, Metabolic Syndrome, Internal medicine, biology, Fpn, Ferroportin, Fatty liver, Liver, DIOS, dysmetabolic iron overload syndrome, CRP, C-reactive protein, Receptors, Leptin, HH, hereditary hemochromatosis, Original Article, IRP, Iron Regulatory Protein, medicine.medical_specialty, Iron Overload, Iron, 030209 endocrinology & metabolism, Mice, Transgenic, IR, Insulin Resistance, SEM, standard error of the mean, 03 medical and health sciences, Insulin resistance, ROS, reactive oxygen species, NASH, Non Alcoholic Steatohepatitis, NAFLD, medicine, Animals, Humans, Molecular Biology, business.industry, NTBI, Non Transferrin Bound Iron, Cell Biology, medicine.disease, RC31-1245, IRS1, Db/db Mouse, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, biology.protein, NAFLD, Non Alcoholic Fatty Liver Disease, Lipid Peroxidation, Steatosis, Metabolic syndrome, business, Oxidative stress, IRE, Iron Responsive Element, T2DM, Type 2 Diabetes Mellitus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ad7abfa625d87337f2502f8e59462Test
http://www.sciencedirect.com/science/article/pii/S2212877821000806Test

المؤلفون: Julie Rodriguez, Nathalie M. Delzenne, Christelle Knudsen, Audrey M. Neyrinck, Martin Beaumont, Laure B. Bindels

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain = Catholic University of Louvain (UCL), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Wallonia (FOOD4GUT project) 1318148 / EU 613979 MyNewGut FP7-609398

المصدر: The Proceedings of the Nutrition Society, Vol. 78, no. 3, p. 319-328 (2019)
Proceedings of the Nutrition Society
Proceedings of the Nutrition Society, Cambridge University Press (CUP), 2019, 78 (3), pp.319-328. ⟨10.1017/S0029665118002756⟩

مصطلحات موضوعية: GLP glucagon-like peptide, 0301 basic medicine, non-alcoholic fatty liver desease, Medicine (miscellaneous), Gut flora, Bioinformatics, Mice, GPR G protein-coupled receptors, 0302 clinical medicine, NASH non-alcoholic steatohepatitis, Non-alcoholic Fatty Liver Disease, Nutrition and Dietetics, Fatty liver, 3. Good health, Liver, NAFLD non-alcoholic fatty liver disease, prebiotic, ALT alanine aminotransferase, 030211 gastroenterology & hepatology, medicine.symptom, ITF inulin-type fructans, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Inflammation, Gut microbiota, Biology, digestive system, 03 medical and health sciences, BA bile acid, medicine, Animals, Humans, gut microbiota, Host (biology), Probiotics, FXR farnesoid X receptor, AST aspartate aminotransferase, Metabolism, medicine.disease, biology.organism_classification, Obesity, Gastrointestinal Microbiome, Disease Models, Animal, Prebiotics, 030104 developmental biology, AhR aryl hydrocarbon receptor, inflammation, LPS lipopolysaccharides, Farnesoid X receptor, Energy Metabolism, Function (biology), Non-alcoholic fatty liver disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e56d9d5d0ddd04fa33e558922e0d67Test
https://doi.org/10.1017/s0029665118002756Test

المؤلفون: Ik Hwan Kim, Moon Kee Meang, Young Min Yoon, Ji Yong Lee, Byung Soo Youn, Tae Hee Lee, Han-Soo Kim, Lee Ji Eun, Yae Eun Park

المصدر: EBioMedicine

مصطلحات موضوعية: 0301 basic medicine, Research paper, Eupatilin, CD, chromone scaffold derivative, Stem cells, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Mice, 0302 clinical medicine, Fibrosis, Chromone scaffold, Transforming Growth Factor beta, Phosphorylation, Myofibroblasts, DHLF, diseased human lung fibroblast, Epithelial–mesenchymal transition, Cell Differentiation, General Medicine, Pirfenidone, Extracellular Matrix, 030220 oncology & carcinogenesis, Nintedanib, Dedifferentiation, Myofibroblast, medicine.drug, NASH, non-alcoholic steatohepatitis, BLM, bleomycin-induced lung fibrosis model, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Bleomycin, In vivo, medicine, Hepatic Stellate Cells, IPF, idiopathic pulmonary fibrosis, Animals, Humans, Smad3 Protein, Flavonoids, business.industry, Fibroblasts, medicine.disease, CS, chromone scaffold, Disease Models, Animal, 030104 developmental biology, chemistry, Gene Expression Regulation, Latent TGF-beta Binding Proteins, Cell Transdifferentiation, Cancer research, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d51eade2f05c6a25366163c9dcd9de8Test
http://europepmc.org/articles/PMC6355727Test

المؤلفون: Carrie E. McCurdy, Kenneth N. Maclean, Paul Kievit, Bryan C. Bergman, Rachel C. Janssen, Peter R. Baker, Christopher M. Mulligan, Tyler Dean, Diana L. Takahashi, Travis Nemkov, Kjersti Aagaard, Hua Jiang, Stephanie R. Wesolowski, Angelo D'Alessandro, Jacob E. Friedman

المصدر: Molecular Metabolism, Vol 18, Iss, Pp 25-41 (2018)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, Steatosis, VIP, variable importance in projection, Hypoxemia, AUC, area under the curve, PC, phosphatidylcholine, 0302 clinical medicine, WSD, Western-style diet, Non-alcoholic Fatty Liver Disease, Pregnancy, Fetal programming, Hyperlipidemia, DAG, diacylglyceride, VLDL, very low-density lipoprotein, Hypoxia, 2. Zero hunger, TG, triglyceride, NEFA, non-esterified fatty acid, NHP, non-human primate, Fatty liver, 3. Good health, Liver, Lipotoxicity, CON, control, OB-WSD, Western-style diet induced obesity group, IV-GTT, intravenous glucose tolerance test, Prenatal Exposure Delayed Effects, Original Article, Female, Diet, Healthy, PLS-DA, partial least squares discriminant analysis, TCA, tricarboxylic acid cycle, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, medicine.medical_specialty, Offspring, NASH, non-alcoholic steatohepatitis, Citric Acid Cycle, Metabolomic, 030209 endocrinology & metabolism, DNL, de novo lipogenesis, TBARs, thiobarbituric acid reactive substances, OB-DR, diet reversal group, 03 medical and health sciences, Fetus, Internal medicine, medicine, TBARS, Animals, Obesity, AA, amino acid, lcsh:RC31-1245, Molecular Biology, Triglycerides, business.industry, Gluconeogenesis, Maternal Nutritional Physiological Phenomena, Cell Biology, medicine.disease, Oxidative Stress, 030104 developmental biology, Endocrinology, Diet, Western, Macaca, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06dccd8288a52f01636dbe7fd72ba0fTest
https://doi.org/10.1016/j.molmet.2018.09.008Test

المؤلفون: Anneleen Remmerie, Liesbet Martens, Charlotte L. Scott

المصدر: Frontiers in Endocrinology
FRONTIERS IN ENDOCRINOLOGY
Frontiers in Endocrinology, Vol 11 (2020)

مصطلحات موضوعية: 0301 basic medicine, POLARIZATION, Endocrinology, Diabetes and Metabolism, ADIPOCYTE DEATH, Adipose tissue, 030209 endocrinology & metabolism, Inflammation, Context (language use), Disease, Review, Biology, liver, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, INFLAMMATION, Non-alcoholic Fatty Liver Disease, LOCAL PROLIFERATION, medicine, Medicine and Health Sciences, Macrophage, Animals, Humans, NASH (non-alcoholic steatohepatitis), Obesity, Metabolic Syndrome, lcsh:RC648-665, NONALCOHOLIC STEATOHEPATITIS, HEPATIC RECRUITMENT, Macrophages, Fatty liver, NICHE, Biology and Life Sciences, single-cell, medicine.disease, macrophages, adipose tissue, 030104 developmental biology, Immunology, CELLS, Metabolic syndrome, medicine.symptom, DEPLETION, Inflammation Mediators, heterogeneity, SPI-C, non-alcoholic fatty liver disease (NAFLD)

وصف الملف: text/plain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d4176e5893622d3bdbf0e1629d38caTest
https://pubmed.ncbi.nlm.nih.gov/32411096Test

المؤلفون: Yanyong Xu, Kavita Jadhav, Yingdong Zhu, Yuan-Yuan Li, Takhar Kasumov, Jiesi Xu, Yang Xu, Luciano Adorini, Yoon Kwang Lee, Yanqiao Zhang, Liya Yin

المصدر: Molecular Metabolism, Vol 9, Iss, Pp 131-140 (2018)
Molecular Metabolism

مصطلحات موضوعية: Male, 0301 basic medicine, Col1α1, collagen type 1 α1, NS, not significant, Receptors, Cytoplasmic and Nuclear, PPARγ, peroxisome proliferation-activated receptor γ, Receptors, G-Protein-Coupled, Mice, IL-1β, interleukin 1β, SHP, small heterodimer partner, α-Sma, alpha smooth muscle actin (α-Sma), HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Tgfβ, transforming growth factor β, Receptor, TG, triglyceride, Bile acid, Chemistry, TGR5, GLP-1, glucagon-like peptide-1, Hep G2 Cells, Peroxisome, G protein-coupled bile acid receptor, 3. Good health, TNFα, tumor necrosis factor α, Pck1, phosphoenoylpyruvate carboxylase 1, TGR5, G protein coupled bile acid receptor (GPBAP), Lipogenesis, BA, bile acid, G6pc, glucose 6-phosphatase, Small heterodimer partner, Original Article, Agonist, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, lcsh:Internal medicine, Timp1, tissue inhibitor of metalloproteinase 1, medicine.drug_class, NASH, non-alcoholic steatohepatitis, Hypercholesterolemia, Diet, High-Fat, Bile Acids and Salts, 03 medical and health sciences, FXR, farnesoid X receptor, Farnesoid X receptor, NAFLD, Internal medicine, medicine, Animals, Humans, Obesity, lcsh:RC31-1245, Molecular Biology, CEBPα, CCAAT/enhancer-binding protein α, DIO, diet-induced obesity, Cell Biology, Atherosclerosis, Mice, Inbred C57BL, BAT, brown adipose tissue, 030104 developmental biology, Endocrinology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6f686d41c1a501b1cae42176973abbTest
http://www.sciencedirect.com/science/article/pii/S2212877817309195Test

المؤلفون: Miguel López, Rubén Nogueiras, Xabier Buqué, Maria J. Gonzalez-Rellan, Daniel Beiroa, Patricia Aspichueta, Uxia Fernandez, Begoña Porteiro, Rosalía Gallego, Carlos Dieguez, Guadalupe Sabio, Marcos F. Fondevila, Johan Fernø, Ana Senra, Alfonso Mora

المساهمون: Ministerio de Economía y Competitividad (España), Xunta de Galicia (España), Heise Vest RHF, Comunidad de Madrid (España), Basque Government (España), Fundación AstraZeneca, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Unión Europea. Comisión Europea, Centro de Investigación Biomedica en Red - CIBER

المصدر: Molecular Metabolism, Vol 8, Iss, Pp 132-143 (2018)
Molecular Metabolism
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: 0301 basic medicine, pIRE, Inositol-requiring enzyme 1 α, pJNK, phospho c-Jun N-terminal kinase, ACC, acetyl-CoA carboxylase, AST, aspartate aminotransferase, XBP1s, X-box binding protein 1, Abcd1, ATP binding cassette subfamily D member 1, Pharmacology, ER stress, endoplasmic reticulum stress, NFκβ, nuclear factor kappa b, FA, free fatty acid, Mice, Liver disease, UPR, unfolded protein response, 0302 clinical medicine, HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, DG, diacylglycerol, Topoisomerase II Inhibitors, IL6, initerleukin 6, Beta oxidation, Acadm, acyl-CoA deshydrogenase, medium chain, GFP, green fluorescent protein, IL10, interleukin 10, Acox, acyl-CoA oxidase 1, TG, triglyceride, Ad, adenovirus, Hep G2 Cells, Acadl, acyl-CoA deshydrogenase, long-chain, i.p., intraperitoneal, FAS, fatty acid synthase, 3. Good health, Liver, Pparα, peroxisome proliferator activated receptor alpha, JNK, c-Jun N-terminal kinase, Lipogenesis, DOX, Doxorubicin, DN, dominant negative, Original Article, ApoB, apolipoprotein b, Quer, quercetin, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, ASM, acid-soluble metabolites, NASH, non-alcoholic steatohepatitis, TNFα, tumor necrosis factor alpha, GAPDH, glyceraldehyde-3-phosphate deshydrogenase, AUC, area under curve, Diet, High-Fat, Cell Line, SPF, specific pathogen free room, 03 medical and health sciences, GTT, glucose test tolerance, ALT, alanine aminotransferase, AAV8, adeno-associated virus serotype 8, medicine, Animals, Humans, Obesity, EC, sterified cholesterol, lcsh:RC31-1245, Molecular Biology, MCD, methionine-choline deficient diet, CHOP, C/EBP-homologous protein, Inflammation, business.industry, OA, oleic acid, Lipid metabolism, DIO, diet-induced obesity, Cell Biology, Lipid Metabolism, medicine.disease, CDHFD, choline-deficient high fat diet, Mice, Inbred C57BL, 030104 developmental biology, Doxorubicin, pACC, phospho acetyl-CoA carboxylase, Hepatic stellate cell, BSA, bovine serum albumin, Tumor Suppressor Protein p53, Steatohepatitis, Steatosis, business, Fatp2, solute carrier family 27 (fatty acid transporter) member 2, IL1β, interleukin 1beta, 030217 neurology & neurosurgery, ITT, insulin test tolerance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7642e1971aebb46c881386960e7affTest
http://www.sciencedirect.com/science/article/pii/S2212877817310116Test

المؤلفون: Adam J. Rauckhorst, Xiaorong Fu, Katherine N. Gibson-Corley, Alvin D. Pewa, Ryan D. Sheldon, Eric B. Taylor, James E. Cox, Charlotte R. Feddersen, Shawn C. Burgess, Adam J. Dupuy, Lawrence R. Gray

المصدر: Molecular Metabolism, Vol 6, Iss 11, Pp 1468-1479 (2017)
Molecular Metabolism

مصطلحات موضوعية: Blood Glucose, 0301 basic medicine, Mitochondria, Liver, Mitochondrion, Mitochondrial Membrane Transport Proteins, Mice, 0302 clinical medicine, HFD, high fat diet, Fibrosis, immune system diseases, Pyruvic Acid, digestive, oral, and skin physiology, Diabetes, Mitochondria, HOMA-IR, homeostatic model assessment of insulin resistance, medicine.anatomical_structure, Liver, Mitochondrial matrix, 030220 oncology & carcinogenesis, Hepatocyte, Original Article, MPC, mitochondrial pyruvate carrier, TCA, tricarboxylic acid cycle, Monocarboxylic Acid Transporters, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, lcsh:Internal medicine, NASH, non-alcoholic steatohepatitis, Anion Transport Proteins, Citric Acid Cycle, T2D, type 2 diabetes, Biology, Diet, High-Fat, Mitochondrial pyruvate carrier (MPC), 03 medical and health sciences, Internal medicine, medicine, Animals, Obesity, lcsh:RC31-1245, Molecular Biology, ITT, insulin tolerance test, Inflammation, NCD, normal chow diet, Gluconeogenesis, Membrane Transport Proteins, nutritional and metabolic diseases, Cell Biology, Metabolism, medicine.disease, Citric acid cycle, Disease Models, Animal, Cytosol, Glucose, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Hyperglycemia, Hepatocytes, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80260421dd9726225c6f9a3cac3cf9faTest
http://www.sciencedirect.com/science/article/pii/S2212877817306828Test

المؤلفون: Thomas Laeger, Louise Fritsche, Christian Baumeier, Norbert Stefan, Annette Schürmann, Sophie Saussenthaler, Andreas Fritsche, Robert W. Schwenk, Maria Rödiger, Hans-Ulrich Häring, Luisa Schlüter, Stella Amelie Alaze

المصدر: Molecular Metabolism
Mol. Metab. 6, 1254-1263 (2017)
Molecular Metabolism, Vol 6, Iss 10, Pp 1254-1263 (2017)

مصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, PPARγ, medicine.medical_treatment, CD36, Adipose tissue, AST, aspartate aminotransferase, SM, skeletal muscle, Mice, F4/80, adhesion G protein-coupled receptor E1, GGT, gamma-glutamyl transpeptidase, Non-alcoholic Fatty Liver Disease, Insulin, rmDPP4, recombinant mouse dipeptidyl peptidase 4, rhDPP4, recombinant human dipeptidyl peptidase 4, Fatty liver, Ad, adenovirus, sWAT, subcutaneous white adipose tissue, Hep G2 Cells, Middle Aged, Dgat2, diacylglycerol O-acyltransferase 2, Cd36, Dpp4, Glp-1, Insulin Resistance, Nafld, Pparγ, TNFα, tumor necrosis factor α, Liver, Cpt1a, carnitine palmitoyltransferase 1a, MOGAT1, monoacylglycerol O-acyltransferase 1, Original Article, Female, medicine.symptom, PPARγ, peroxisome proliferator activated receptor gamma, Dpp4-Liv-Tg, transgenic mice with hepatocyte-specific Dpp4 overexpression, NFκB, nuclear factor-κB, Adult, lcsh:Internal medicine, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, Akt, Akt serine–threonine protein kinase, HOMA-IR, homeostatic model assessment for insulin resistance, IL6, interleukin 6, NASH, non-alcoholic steatohepatitis, Dipeptidyl Peptidase 4, gWAT, gonadal white adipose tissue, Inflammation, Srebf1, sterol regulatory element binding transcription factor 1, Mice, Transgenic, Biology, DPP4, 03 medical and health sciences, Insulin resistance, Internal medicine, NAFLD, ALT, alanine aminotransferase, medicine, Animals, Humans, ApoB, apolipoprotein B, GLP-1, glucagon-like peptide 1, Obesity, lcsh:RC31-1245, Molecular Biology, pAkt, phosphorylated Akt serine–threonine protein kinase, Cell Biology, medicine.disease, CD36, fatty acid translocase, DPP4, dipeptidyl peptidase 4, WT, wild-type, BAT, brown adipose tissue, Insulin receptor, Disease Models, Animal, 030104 developmental biology, Endocrinology, biology.protein, Hepatocytes, Gfp, green fluorescent protein, Steatosis, GLP-1, MCP1, chemokine (C-C motif) ligand 2, MAPK, mitogen-activated protein kinase

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec108ccaaae2e081b54e4ea79fe8b459Test

المؤلفون: Naoyuki Okita, Yuka Sudo, Yuhei Mizunoe, Hiromine Yasukawa, Masaaki Komatsu, Arisa Negishi, Masaki Kobayashi, Ayana Hoshino, Daiki Natori, Shukoh Watanabe, Yoshikazu Higami

المصدر: Redox Biology
Redox Biology, Vol 15, Iss C, Pp 115-124 (2018)

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Cellular homeostasis, medicine.disease_cause, Biochemistry, Autophagy-Related Protein 5, chemistry.chemical_compound, Mice, 0302 clinical medicine, HFD, high fat diet, NAD(P)H Dehydrogenase (Quinone), shRNA, small hairpin RNA, lcsh:QH301-705.5, Ho-1, heme oxygenase-1, GFP, green fluorescent protein, chemistry.chemical_classification, Mice, Knockout, Proto-Oncogene Proteins c-yes, lcsh:R5-920, Kelch-Like ECH-Associated Protein 1, mTOR, mechanistic target of rapamycin, TOR Serine-Threonine Kinases, p62, Cell biology, Keap1, Kelch-like ECH-associated protein 1, 030220 oncology & carcinogenesis, RFP, red fluorescent protein, ROS, reactive oxygen species, MCP1, monocyte chemoattractant protein-1, Antioxidant, lcsh:Medicine (General), LC3, microtubule-associated protein 1 light chain 3 (MAP1LC3), Nicotinamide adenine dinucleotide phosphate, Research Paper, Signal Transduction, NAFLD, non-alcoholic fatty liver disease, NF-E2-Related Factor 2, NASH, non-alcoholic steatohepatitis, Biology, DMEM, Dulbecco's Modified Eagle Medium, Keap1–Nrf2 system, 03 medical and health sciences, RT-PCR, reverse transcription polymerase chain reaction, Nqo1, nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1, ATG, autophagy-related gene, medicine, Autophagy, Animals, Humans, Nrf2, nuclear factor (erythroid-derived 2)-like 2, PI3K/AKT/mTOR pathway, Reactive oxygen species, Organic Chemistry, Trehalose, Membrane Proteins, KEAP1, MEF, mouse embryonic fibroblast, Oxidative Stress, 030104 developmental biology, chemistry, lcsh:Biology (General), Oxidative stress, Heme Oxygenase-1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20769cb875708e64386013f26c149eb6Test
http://europepmc.org/articles/PMC5730428Test