المؤلفون: Budriesi, R, Cacciaguerra, S, Di Toro, R, Bolognesi, M L, Chiarini, A, Minarini, A, Rosini, M, Spampinato, S, Tumiatti, V, Melchiorre, C

مصطلحات موضوعية: Male, Receptor, Muscarinic M3, Receptor, Muscarinic M2, Dose-Response Relationship, Drug, Receptor, Muscarinic M4, Receptor, Muscarinic M1, (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride, Muscarinic Antagonists, Muscarinic Agonists, Receptors, Muscarinic, Rats, Benzodiazepines, Vas Deferens, Papers, Polyamines, Animals, Humans, Rabbits, Rats, Wistar, Muscle Contraction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::92d50fd551c998210fc6063a1d433035Test
https://europepmc.org/articles/PMC1572637Test/

المؤلفون: Giraldo E, Micheletti R, Montagna E, Giachetti A, maria alessandra vigano, Ladinsky H, Melchiorre C

المصدر: Europe PubMed Central

مصطلحات موضوعية: Binding Sites, Heart Rate, Guinea Pigs, Scopolamine Derivatives, Animals, Parasympatholytics, Heart, Diamines, In Vitro Techniques, N-Methylscopolamine, Receptors, Muscarinic, Rats

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::feb570b0ae35ed9b2671fcfd3bec25e2Test
http://europepmc.org/abstract/med/3252019Test

المؤلفون: Manuela Bartolini, Maria Laura Bolognesi, Simona Capsoni, Vincenza Andrisano, Carlo Melchiorre, Elisa Margotti, Antonino Cattaneo, Andrea Cavalli, Maurizio Recanatini

المساهمون: Cavalli, A, Bolognesi, Ml, Capsoni, Simona, Andrisano, V, Bartolini, M, Margotti, E, Cattaneo, Antonino, Recanatini, M, Melchiorre, C., Cavalli A., Bolognesi M. L., Capsoni S., Andrisano V., Bartolini M., Margotti E., Cattaneo A., Recanatini M., Melchiorre C.

مصطلحات موضوعية: Models, Molecular, Amyloid β, Drug Evaluation, Preclinical, Socio-culturale, Mice, Transgenic, Disease, Pharmacology, Catalysis, Lesion, Mice, Structure-Activity Relationship, Drug Delivery Systems, Alzheimer Disease, Alkanes, Ethylamines, medicine, Animals, Humans, Molecular Structure, Chemistry, Neurodegeneration, Stereoisomerism, General Medicine, General Chemistry, medicine.disease, Small molecule, Mice transgenic, Disease Models, Animal, Tau phosphorylation, medicine.symptom, Alzheimer's disease, Neuroscience

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e29170d53505527751bec9f667ae5aTest
http://hdl.handle.net/11392/2349941Test

المؤلفون: Maria Laura Bolognesi, Carlo Melchiorre, Anna Minarini, Michela Rosini, Vincenzo Tumiatti

المساهمون: Melchiorre C, Bolognesi ML, Minarini A, Rosini M, Tumiatti V

المصدر: Journal of Medicinal Chemistry. 53:5906-5914

مصطلحات موضوعية: Structure-Activity Relationship, Chemistry, Drug discovery, Drug Design, Models, Animal, Drug Discovery, Polyamines, Animals, Molecular Medicine, Design strategy, Ligands, Ligand (biochemistry), Combinatorial chemistry

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b5c2965b7f4133b33fcaddd8fb04e3Test
https://doi.org/10.1021/jm100293fTest

المؤلفون: Gianni Sagratini, Dario Giardinà, Ugo Gulini, Piero Angeli, Michela Buccioni, Carlo Melchiorre, Gabriella Marucci, Rodolfo Testa

المساهمون: Marucci G., Angeli P., Buccioni M., Gulini U., Melchiorre C., Sagratini G., Testa R., Giardinà D.

المصدر: European Journal of Pharmacology. 522:100-107

مصطلحات موضوعية: Male, medicine.medical_specialty, Adrenergic receptor, Aorta, Thoracic, In Vitro Techniques, Binding, Competitive, Clonidine, Methoxamine, Norepinephrine, Vas Deferens, Quinoxalines, Receptors, Adrenergic, alpha-1, medicine.artery, Internal medicine, medicine, Animals, Thoracic aorta, Rats, Wistar, Adrenergic alpha-Antagonists, Pharmacology, Aorta, Lagomorpha, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Vas deferens, Antagonist, biology.organism_classification, Rats, medicine.anatomical_structure, Endocrinology, Vasoconstriction, Adrenergic alpha-1 Receptor Antagonists, Quinazolines, Adrenergic alpha-1 Receptor Agonists, Rabbits, Antagonism, Adrenergic alpha-Agonists, Muscle Contraction, Blood vessel

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6bda297c67c05ab9cdfe68e5ce9603Test
https://doi.org/10.1016/j.ejphar.2005.08.044Test

المؤلفون: Richard H. Clothier, Anna Minarini, Vincenzo Tumiatti, Ian R. Mellor, Terence L. Parker, Carlo Melchiorre, Michela Rosini, Jane Ogilvie, Florentina Pluteanu

المساهمون: MELLOR I. R., OGILVIE J., PLUTEANU F., CLOTHIER R. H., PARKER T. L., ROSINI M., MINARINI A., TUMIATTI V., MELCHIORRE C.

المصدر: European Journal of Pharmacology. 505:37-50

مصطلحات موضوعية: Male, Patch-Clamp Techniques, Central nervous system, Diamines, Pharmacology, Biology, Models, Biological, Membrane Potentials, Structure-Activity Relationship, chemistry.chemical_compound, Fetus, Dorsal root ganglion, Pregnancy, Ganglia, Spinal, Methoctramine, medicine, Animals, Patch clamp, Rats, Wistar, Binding site, Neurons, Membrane potential, Dose-Response Relationship, Drug, Age Factors, Hydrogen-Ion Concentration, Rats, medicine.anatomical_structure, chemistry, Capsaicin, Female, Neuron, Neuroscience

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ad2169d871313efa4bd548b25f99beTest
https://doi.org/10.1016/j.ejphar.2004.10.005Test

المؤلفون: Carlo Melchiorre, Glauco Tarozzo, Andrea Cavalli, Daniela Pizzirani, Luca Goldoni, Giovanni Bottegoni, Maria Letizia Trincavelli, Angelo Reggiani, Elena Simoni, Michela Rosini, Claudia Martini, Simona Daniele, Daniele Piomelli

المساهمون: Simoni E., Daniele S., Bottegoni G., Pizzirani D., Trincavelli M.L., Goldoni L., Tarozzo G., Reggiani A., Martini C., Piomelli D., Melchiorre C., Rosini M., Cavalli A.

المصدر: Simoni, E; Daniele, S; Bottegoni, G; Pizzirani, D; Trincavelli, ML; Goldoni, L; et al.(2012). Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. Journal of Medicinal Chemistry, 55(22), 9708-9721. doi: 10.1021/jm3009458. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/86n0q0gkTest

مصطلحات موضوعية: Male, Aché, Pharmacology, Receptors, N-Methyl-D-Aspartate, Neuroprotection, Rats, Sprague-Dawley, Neuroblastoma, chemistry.chemical_compound, Alzheimer Disease, Memantine, Galantamine, medicine, Animals, Humans, Computer Simulation, MEDICINAL CHEMISTRY, Receptor, Cell Proliferation, Cerebral Cortex, Chemistry, Neurotoxicity, medicine.disease, COMPUTATIONAL CHEMISTRY, Acetylcholinesterase, language.human_language, Rats, DRUG DISCOVERY, Drug Combinations, Neuroprotective Agents, Biochemistry, ALZHEIMER'S DISEASE, nervous system, Drug Design, language, Feasibility Studies, Molecular Medicine, NMDA receptor, Cholinesterase Inhibitors, medicine.drug

وصف الملف: application/pdf; STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9e2da329aa1c0e8d1b4bb0f632c25bTest
http://www.escholarship.org/uc/item/86n0q0gkTest

المؤلفون: Carlo Melchiorre, Maria Laura Bolognesi, Anna Minarini, Michela Rosini, Elena Simoni, Vincenzo Tumiatti

المساهمون: Bolognesi M.L., Simoni E., Rosini M., Minarini A., Tumiatti V., Melchiorre C

مصطلحات موضوعية: Drug, media_common.quotation_subject, Computational biology, Disease, Pharmacology, Ligands, Alzheimer Disease, Alkanes, medicine, Ethylamines, Animals, Humans, Enzyme Inhibitors, media_common, Amyloid beta-Peptides, Thioctic Acid, Drug discovery, business.industry, General Medicine, DRUG DISCOVERY, Tacrine, Molecular targets, Acetylcholinesterase, business, NEURODEGENERATIVE DISEASES, medicine.drug

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd763a546e1db61961b2fdbedbe66576Test
http://hdl.handle.net/11585/108616Test

المؤلفون: Gianpaolo Chiriano, Maria Laura Bolognesi, Giovanni Bottegoni, Manfred Windisch, Vincenzo Tumiatti, Michela Rosini, Carlo Melchiorre, Manuela Bartolini, Andrea Cavalli, Vincenza Andrisano, Valentina Maestri, Anna Minarini, Stefan Czvitkovich, Francesca Mancini

المساهمون: Bolognesi ML, Chiriano G, Bartolini M, Mancini F, Bottegoni G, Maestri V, Czvitkovich S, Windisch M, Cavalli A, Minarini A, Rosini M, Tumiatti V, Andrisano V, Melchiorre C.

مصطلحات موضوعية: Models, Molecular, Aché, Stereochemistry, Cell Survival, Molecular Conformation, In Vitro Techniques, Ligands, Bivalent (genetics), chemistry.chemical_compound, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Alkanes, Ethylamines, Animals, Humans, Neurons, Amyloid beta-Peptides, ALZHEIMER’S DISEASE, Affinities, language.human_language, In vitro, Peptide Fragments, APP metabolism, Monomer, chemistry, Butyrylcholinesterase, Amyloid aggregation, language, Acetylcholinesterase, Molecular Medicine, Cholinesterase Inhibitors, Amyloid Precursor Protein Secretases, Chickens, Protein Binding

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6915ab35436d2c99c205c324dfb6ba17Test
http://hdl.handle.net/11585/109307Test

المؤلفون: Elena Simoni, Christian Bergamini, Patrizia Hrelia, Maria Laura Bolognesi, Andrea Tarozzi, Anna Minarini, Sandip Bains, Andrea Cavalli, Romana Fato, Roberto Motterlini, Carlo Melchiorre, Michela Rosini, Giorgio Lenaz

المساهمون: Simoni E., Bergamini C., Fato R., Tarozzi A., Bains S., Motterlini R., Cavalli A., Bolognesi M.L., Minarini A., Hrelia P., Lenaz G., Rosini M., Melchiorre C.

المصدر: Journal of medicinal chemistry. 53(19)

مصطلحات موضوعية: Curcumin, Antineoplastic Agents, Mitochondrion, In Vitro Techniques, Antioxidants, Cell Line, chemistry.chemical_compound, Enzyme activator, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Polyamines, Structure–activity relationship, Animals, Humans, Cytotoxicity, Heme, Cell Proliferation, Endothelial Cells, Stereoisomerism, Fibroblasts, Mitochondria, Enzyme Activation, Oxidative Stress, Neuroprotective Agents, chemistry, Biochemistry, Molecular Medicine, Cattle, Endothelium, Vascular, Drug Screening Assays, Antitumor, Polyamine, Reactive Oxygen Species, Intracellular, Heme Oxygenase-1

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5100c44fff37536eeadc99a35c449362Test
https://pubmed.ncbi.nlm.nih.gov/20831222Test