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المصدر: Biomolecules
Biomolecules, Vol 11, Iss 846, p 846 (2021)
Biomolecules, 11 (6)مصطلحات موضوعية: Nociception, 0301 basic medicine, Spinal Cord Dorsal Horn, glycine, GABA, pain, inhibition, spinal cord, dorsal horn, hyperalgesia, allodynia, circuit, mouse, Hindbrain, Review, Microbiology, Biochemistry, Protein Structure, Secondary, 03 medical and health sciences, Receptors, Glycine, 0302 clinical medicine, medicine, Animals, Humans, Propofol, Molecular Biology, Glycine receptor, business.industry, Drug discovery, Chronic pain, medicine.disease, Spinal cord, QR1-502, 3. Good health, 030104 developmental biology, Allodynia, medicine.anatomical_structure, Zonisamide, Hyperalgesia, medicine.symptom, business, Neuroscience, 030217 neurology & neurosurgery, Endocannabinoids
وصف الملف: application/application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76841fa18b1c0bfeffdf42dcf300c7cTest
http://europepmc.org/articles/PMC8228028Test -
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المؤلفون: Daniela Mennickent, Sergio Triviño, Gustavo Moraga-Cid, Claudia Pérez, Jorge Fuentealba, Luis G. Aguayo, Victoria P San Martín, José Becerra, Pamela A. Godoy, Gonzalo E. Yévenes, Patricio A. Castro, Oscar Ramirez-Molina, Javiera Gavilán, Tiare Silva-Grecchi, Leonardo Guzmán
المصدر: Journal of Alzheimer's Disease. 67:343-356
مصطلحات موضوعية: 0301 basic medicine, Sparteine, Receptors, Nicotinic, Pharmacology, Hippocampus, PC12 Cells, Neuroprotection, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Calcium Signaling, Protein kinase B, PI3K/AKT/mTOR pathway, Cytisus, Acetylcholine receptor, Neurons, Amyloid beta-Peptides, Chemistry, General Neuroscience, Neurotoxicity, Long-term potentiation, General Medicine, medicine.disease, Rats, Mice, Inbred C57BL, Oncogene Protein v-akt, Psychiatry and Mental health, Clinical Psychology, Nicotinic acetylcholine receptor, HEK293 Cells, Neuroprotective Agents, 030104 developmental biology, Nicotinic agonist, Synapses, Nerve Net, Geriatrics and Gerontology, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076ffcf172600c891bc4899b937ff333Test
https://doi.org/10.3233/jad-180945Test -
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المؤلفون: Javiera Gavilán, Luis G. Aguayo, Terrance M. Egan, Jessica D. Panes, Tiare Silva-Grecchi, Maria Cecilia Fuentes-Fuentes, Pamela A. Godoy, Gonzalo E. Yévenes, Leonardo Guzmán, Jorge Fuentealba, Francisco Saez-Orellana
المصدر: Neuropharmacology. 128:366-378
مصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, Cell Survival, Amyloid beta, Neurotransmission, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Pregnancy, Extracellular, Animals, PPADS, Receptor, Cells, Cultured, Cerebral Cortex, Neurons, Pharmacology, Neurotransmitter Agents, Amyloid beta-Peptides, biology, Apyrase, Purinergic receptor, Excitatory Postsynaptic Potentials, Embryo, Mammalian, Peptide Fragments, Rats, Cell biology, 030104 developmental biology, chemistry, Receptors, Purinergic P2X, Pyridoxal Phosphate, biology.protein, Female, Disks Large Homolog 4 Protein, Microtubule-Associated Proteins, Neuroscience, Platelet Aggregation Inhibitors, 030217 neurology & neurosurgery, Intracellular
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8158b65a275bc2e4b8a22a1abfbcb9Test
https://doi.org/10.1016/j.neuropharm.2017.10.027Test -
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المؤلفون: Jorge Fuentealba, Chunyang Jin, Leonardo Guzmán, Daniela Nova, Loreto San Martin, Fabian Cerda, Luis G. Aguayo, Tania Hernandez, Gonzalo E. Yévenes, Veronica Jimenez
المصدر: Journal of Biological Chemistry. 291:18791-18798
مصطلحات موضوعية: 0301 basic medicine, G protein, Neurotransmission, Pharmacology, Inhibitory postsynaptic potential, Synaptic Transmission, Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, Receptors, Glycine, 0302 clinical medicine, Neurobiology, In vivo, GTP-Binding Protein gamma Subunits, Animals, Humans, Receptor, Molecular Biology, Glycine receptor, Ethanol, GTP-Binding Protein beta Subunits, Long-term potentiation, Cell Biology, HEK293 Cells, 030104 developmental biology, chemistry, Peptides, Alcoholic Intoxication, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d4671ab83161ff8364cff1c755e148Test
https://doi.org/10.1074/jbc.m116.740555Test -
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المؤلفون: Alessandra Di Lio, Cesar O. Lara, Gustavo Moraga-Cid, Hanns Ulrich Zeilhofer, Mario A. Acuña, Braulio Muñoz, Carlos F. Burgos, Gonzalo E. Yévenes, Pierre-Jean Corringer, Dietmar Benke, William T. Ralvenius
المساهمون: Institute of Pharmacology and Toxicology [Zurich], Universität Zürich [Zürich] = University of Zurich (UZH), Neuroscience Center Zurich, Universidad de Concepción - University of Concepcion [Chile], Drug Discovery Network Zurich, Récepteurs Canaux - Channel Receptors, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), This work was supported by grants from the Swiss National Science Foundation (SNSF, 131093) and an advanced investigator grant from the European Research Council (ERC AdG DHISP 250128) to H.U. Zeilhofer, by grants from the Fondation de la Recherche Médicale, Institut Pasteur, to G. Moraga-Cid and P.-J. Corringer and the Agence Nationale de la Recherche Grants to P.-J. Corringer, VRID-University of Concepcion 213.033.106-1.0, and FONDECYT 1140515 to G.E. Yévenes. G.E. Yévenes was supported through a Forschungskredit from the University of Zurich. W.T. Ralvenius was supported through a fellowship from the Stiftung für Forschung of the Medical Faculty, University of Zurich., European Project: 250128,EC:FP7:ERC,ERC-2009-AdG,DHISP(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2016, 126 (7), pp.2547-2560. ⟨10.1172/JCI83817⟩
Journal of Clinical Investigation, 2016, 126 (7), pp.2547-2560. ⟨10.1172/JCI83817⟩مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Protein Conformation, Phenylalanine, Protein subunit, [SDV]Life Sciences [q-bio], Pain, Mice, Transgenic, Neurotransmission, Inhibitory postsynaptic potential, Mice, 03 medical and health sciences, Receptors, Glycine, 0302 clinical medicine, Phenols, medicine, Animals, Humans, Pain Management, Phosphorylation, Receptor, Glycine receptor, Inflammation, Neurons, Chemistry, [SCCO.NEUR]Cognitive science/Neuroscience, Long-term potentiation, General Medicine, Recombinant Proteins, Cell biology, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, Spinal Cord, Biochemistry, Hyperalgesia, Female, Inflammation Mediators, medicine.symptom, Allosteric Site, 030217 neurology & neurosurgery, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63404102e8bf16d4b8ce5731eb26d008Test
https://www.jci.org/articles/view/83817Test -
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المؤلفون: Carolina Benitez, Gonzalo E. Yévenes, Luis F. Barraza, Jorge Fuentealba, Carola Díaz, Veronica Jimenez, Joel B. Alderete, Leonardo Guzmán, Felipe Vidal
المصدر: Nanomedicine : nanotechnology, biology, and medicine. 14(7)
مصطلحات موضوعية: Male, Dendrimers, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, Apoptosis, 02 engineering and technology, Polyethylene glycol, Molecular Dynamics Simulation, 010402 general chemistry, 01 natural sciences, Nanomaterials, chemistry.chemical_compound, Mice, Plasma, Folic Acid, In vivo, Dendrimer, PEG ratio, Animals, Humans, General Materials Science, Cytotoxicity, Cell Proliferation, Drug Carriers, Rational design, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Mice, Inbred C57BL, HEK293 Cells, chemistry, Biophysics, Molecular Medicine, Surface modification, 0210 nano-technology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f297d2b27648456756aeb3fd1b22bf6Test
https://pubmed.ncbi.nlm.nih.gov/30048814Test -
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المؤلفون: Luis G. Aguayo, Robert J. Harvey, Gonzalo E. Yévenes, Carlos F. Burgos, Gustavo Moraga-Cid, Andrea Sanchez, Loreto San Martin
المصدر: Journal of Pharmacology and Experimental Therapeutics. 353:80-90
مصطلحات موضوعية: Models, Molecular, G protein, Molecular Sequence Data, GTP-Binding Protein beta Subunits, Receptors, Glycine, Neuropharmacology, GTP-Binding Protein gamma Subunits, Heterotrimeric G protein, Animals, Humans, Amino Acid Sequence, Glycine receptor, Pharmacology, Ethanol, Chemistry, Protein Structure, Tertiary, Rats, Alternative Splicing, Transmembrane domain, HEK293 Cells, Biochemistry, Mutation, Biophysics, Molecular Medicine, Intracellular, Cys-loop receptors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a870e29ca8c52bd215f32cd73a91bd5Test
https://doi.org/10.1124/jpet.114.221143Test -
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المساهمون: University of Zurich, Zeilhofer, Hanns Ulrich
المصدر: Cellular and molecular life sciences : CMLS. 75(3)
مصطلحات موضوعية: 0301 basic medicine, Allosteric regulation, 2804 Cellular and Molecular Neuroscience, 10050 Institute of Pharmacology and Toxicology, Pain, 610 Medicine & health, Disinhibition, Pharmacology, Neurotransmission, Adverse effect, Inhibitory postsynaptic potential, 1307 Cell Biology, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Receptors, Glycine, Glycine Plasma Membrane Transport Proteins, Central inhibition, Drug Discovery, 1312 Molecular Biology, Therapeutic application, medicine, Animals, Humans, Molecular Targeted Therapy, Molecular Biology, Glycine receptor, Analgesics, business.industry, Drug discovery, Chronic pain, Cell Biology, Drugs, Investigational, medicine.disease, Neuropathy, 3004 Pharmacology, 030104 developmental biology, Nociception, 1313 Molecular Medicine, Glycine, 570 Life sciences, biology, Molecular Medicine, Analgesia, business, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a8efd4f98dd5d8d7df26d70f2ecd38Test
https://pubmed.ncbi.nlm.nih.gov/28791431Test -
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المؤلفون: Luis G. Aguayo, Gonzalo E. Yévenes, Carlos F. Burgos
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, GLIC, Inhibitory postsynaptic potential, Protein Structure, Secondary, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Receptors, Glycine, Animals, Humans, Receptor, Glycine receptor, Ion channel, Acetylcholine receptor, Pharmacology, Minireview—A Latin American Perspective on Ion Channels, Binding Sites, Chemistry, Strychnine, 030104 developmental biology, Biochemistry, Glycine, Biophysics, Molecular Medicine, Ion Channel Gating, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4cbcbef502170211956358a65e6d80Test
https://europepmc.org/articles/PMC4998662Test/ -
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المؤلفون: Khaled Zemoura, Marisa Schenkel, Hanns Ulrich Zeilhofer, Dietmar Benke, Gonzalo E. Yévenes, Mario A. Acuña
المصدر: The Journal of biological chemistry
مصطلحات موضوعية: Proteasome Endopeptidase Complex, Immune receptor, Biology, GABAB receptor, Endoplasmic-reticulum-associated protein degradation, Endoplasmic Reticulum, Biochemistry, gamma-Aminobutyric acid, 03 medical and health sciences, 0302 clinical medicine, Neurobiology, Cell surface receptor, medicine, Animals, Humans, Rats, Wistar, Receptor, Molecular Biology, gamma-Aminobutyric Acid, 030304 developmental biology, Neurons, 0303 health sciences, Ubiquitin, GABAA receptor, Ubiquitination, Endoplasmic Reticulum-Associated Degradation, Cell Biology, Rats, Cell biology, HEK293 Cells, Metabotropic receptor, Gene Expression Regulation, Receptors, GABA-B, nervous system, Proteolysis, 030217 neurology & neurosurgery, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ade33fa4302e1f4f70a368cdf972d0aTest
https://doi.org/10.1074/jbc.m113.514745Test
