المؤلفون: Paul Kinchesh, James M Thompson, Stuart Gilchrist, Barry R. Davies, Jennifer L. Martin, Mark J. O'Connor, Veerle Kersemans, Sean Smart, Yanyan Jiang, Anderson J. Ryan, Kay Shigemori, Maryam Alkadhimi, Mark A. Hill

المصدر: British Journal of Cancer

مصطلحات موضوعية: Thorax, Cancer Research, Radiation-Sensitizing Agents, Lung Neoplasms, Article, Piperazines, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Therapeutic index, Carcinoma, Non-Small-Cell Lung, medicine, Animals, Lung cancer, Cancer models, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, Radiotherapy, business.industry, Magnetic resonance imaging, Histology, medicine.disease, Disease Models, Animal, Therapeutic Index, Treatment Outcome, Oncology, chemistry, Tolerability, 030220 oncology & carcinogenesis, Toxicity, Phthalazines, Female, business, Nuclear medicine, Non-small-cell lung cancer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e600d6088887f3370444bc9ed4771b5bTest
http://europepmc.org/articles/PMC8144220Test

المؤلفون: Kyoko Nakamura, Neil H. James, Paul Farrington, Ankur Karmokar, Susan J. Bickerton, Simon J. Dovedi, Gareth Hughes, Timothy M Illidge, Elaine Cadogan, Antonio Ramos-Montoya, Barry R. Davies, Viia Valge-Archer

المصدر: Nakamura, K, Karmokar, A, Farrington, P M, James, N H, Ramos-Montoya, A, Bickerton, S J, Hughes, G D, Illidge, T M, Cadogan, E B, Davies, B R, Dovedi, S J & Valge-Archer, V 2021, ' Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control ', Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 27, no. 15, pp. 4353-4366 . https://doi.org/10.1158/1078-0432.CCR-20-3701Test

مصطلحات موضوعية: Cancer Research, Tumor microenvironment, Radiation-Sensitizing Agents, Combination therapy, Manchester Cancer Research Centre, Chemistry, DNA damage, ResearchInstitutes_Networks_Beacons/mcrc, DNA Repair Pathway, DNA-Activated Protein Kinase, Triazoles, Non-homologous end joining, Granzyme B, Mice, Immune system, Oncology, Purines, Cell Line, Tumor, Neoplasms, Interferon Type I, Cancer research, Animals, Protein Kinase Inhibitors, CD8, Pyrans

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361b99c301898bba1de98f81587a182cTest
https://research.manchester.ac.uk/en/publications/08e42339-29d6-407b-83fc-396678da590eTest

المؤلفون: Ammar Adam, David J. Owen, Justin Cidado, Claire Patterson, Matthew Skinner, Stuart Purbrick, Lorraine Graham, Petar Pop-Damkov, Michael Giannis, Srividya B. Balachander, Francis D. Gibbons, William McCoull, Marianne Ashford, Hill Kathryn Jane, Martin Wild, Eric Gangl, Stephen Fawell, Corinne Reimer, Sean Redmond, Paul D. Kemmitt, Barry R. Davies, Jamal Carlos Saeh, Shenghua Wen, J. Paul Secrist, Alwin Schuller, Edward J. Hennessy, Sonya Gales, Iain Grant, Alexander R. Harmer, Jeremy S. Parker, Brian Kelly

المصدر: Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Male, 0301 basic medicine, Drug, Dendrimers, QH301-705.5, media_common.quotation_subject, bcl-X Protein, Medicine (miscellaneous), Drug development, Antineoplastic Agents, Mice, SCID, Pharmacology, Conjugated system, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, Targeted therapies, Dogs, 0302 clinical medicine, Therapeutic index, Neoplasms, Dendrimer, Tumor Cells, Cultured, Animals, Humans, Medicine, Biology (General), Rats, Wistar, media_common, Haematological cancer, business.industry, Xenograft Model Antitumor Assays, Rats, Mice, Inbred C57BL, Therapeutic Index, 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, Tolerability, 030220 oncology & carcinogenesis, Drug delivery, Female, General Agricultural and Biological Sciences, business, Conjugate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f928851dba9fe7a39b683d8c12e8a5dTest
https://doi.org/10.1038/s42003-020-01631-8Test

المؤلفون: Srividya B, Balachander, Steven W, Criscione, Kate F, Byth, Justin, Cidado, Ammar, Adam, Paula, Lewis, Terry, Macintyre, Shenghua, Wen, Deborah, Lawson, Kathleen, Burke, Tristan, Lubinski, Jeffrey W, Tyner, Stephen E, Kurtz, Shannon K, McWeeney, Jeffrey, Varnes, R Bruce, Diebold, Thomas, Gero, Stephanos, Ioannidis, Edward J, Hennessy, William, McCoull, Jamal C, Saeh, Areya, Tabatabai, Omid, Tavana, Nancy, Su, Alwin, Schuller, Mathew J, Garnett, Patricia, Jaaks, Elizabeth A, Coker, Gareth P, Gregory, Andrea, Newbold, Ricky W, Johnstone, Eric, Gangl, Martin, Wild, Michael, Zinda, J Paul, Secrist, Barry R, Davies, Stephen E, Fawell, Francis D, Gibbons

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 26(24)

مصطلحات موضوعية: bcl-X Protein, Antineoplastic Agents, Apoptosis, Mice, SCID, Thrombocytopenia, Xenograft Model Antitumor Assays, Mice, Piperidines, Proto-Oncogene Proteins c-bcl-2, Mice, Inbred NOD, Hematologic Neoplasms, Benzamides, Tumor Cells, Cultured, Animals, Humans, Female, Sulfones, Cell Proliferation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::a85a5f05ec69d49e1282eb570e6bdc06Test
https://pubmed.ncbi.nlm.nih.gov/32988967Test

المؤلفون: Mark J. O'Connor, Stephen Fawell, Barry R. Davies, Joanne Wilson, Valeria Follia, Paul W. G. Wijnhoven, M. Raymond V. Finlay, Mercedes Vazquez-Chantada, Neil H. James, Elaine Cadogan, Aaron Smith, Paul Farrington, Simon J. Hollingsworth, Lenka Oplustil O'Connor, Emma Dean, Ankur Karmokar, Sophie E. Willis, Frederick W. Goldberg, Gillian M. Lamont, Antonio Ramos-Montoya, Stephanie Ling, D. Beattie, Jacqueline H. L. Fok, Jonathan Cairns, Jenni Nikkilä

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: 0301 basic medicine, Genome instability, Lung Neoplasms, General Physics and Astronomy, Apoptosis, DNA-Activated Protein Kinase, Radiation Tolerance, Piperazines, Polyethylene Glycols, chemistry.chemical_compound, Mice, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, lcsh:Science, Multidisciplinary, Antibiotics, Antineoplastic, Drug Synergism, 030220 oncology & carcinogenesis, PARP inhibitor, Growth inhibition, medicine.symptom, Clinical pharmacology, DNA damage, Science, Drug development, Poly(ADP-ribose) Polymerase Inhibitors, General Biochemistry, Genetics and Molecular Biology, Article, Genomic Instability, Olaparib, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Protein kinase A, Protein Kinase Inhibitors, Cell Proliferation, Pyrans, Radiotherapy, General Chemistry, Triazoles, Xenograft Model Antitumor Assays, 030104 developmental biology, chemistry, Mechanism of action, A549 Cells, Doxorubicin, Purines, Cancer research, Phthalazines, lcsh:Q

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2343caeeb96aedc19f4ab9d664878eTest
http://europepmc.org/articles/PMC6838110Test

المؤلفون: Fara Brasó-Maristany, Mònica Sánchez-Guixé, Andreu Ódena, Aleix Prat, Olga Rodriguez, Yasir H. Ibrahim, Alejandra Bruna, Elza C. de Bruin, Barry R. Davies, Alan Barnicle, Laia Monserrat, Judit Grueso, Carlos Caldas, Guillermo Villacampa, Nicholas C. Turner, Avinash Reddy, Paolo Nuciforo, Albert Gris-Oliver, Joaquín Arribas, Violeta Serra, Gordon B. Mills, Maurizio Scaltriti, Caroline S. Hirst, Mafalda Oliveira, Gaia Schiavon, Cristina Saura, Marta Guzman, Marta Palafox, Pedram Razavi, Mireia Parés, Rodrigo Dienstmann

المصدر: Clin Cancer Res

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Paclitaxel, Class I Phosphatidylinositol 3-Kinases, DNA Mutational Analysis, AKT1, P70-S6 Kinase 1, Breast Neoplasms, Tuberous Sclerosis Complex 1 Protein, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Breast cancer, Antineoplastic Combined Chemotherapy Protocols, medicine, Biomarkers, Tumor, PTEN, Animals, Humans, Pyrroles, Breast, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Mastectomy, biology, Fulvestrant, business.industry, TOR Serine-Threonine Kinases, Ribosomal Protein S6 Kinases, 70-kDa, medicine.disease, Prognosis, Metastatic breast cancer, Xenograft Model Antitumor Assays, 030104 developmental biology, Pyrimidines, Oncology, Chemotherapy, Adjuvant, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, biology.protein, Cancer research, Female, business, Proto-Oncogene Proteins c-akt, medicine.drug, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef93ddf12491d1bbf7d5667c25fa96d7Test
https://pubmed.ncbi.nlm.nih.gov/32220884Test

المؤلفون: A. Robert MacLeod, Kazuhiro Yoshikawa, Kazuko Sakai, Youngsoo Kim, Hayley Campbell, Koichi Sugimoto, Stephanie Klein, Marco A. De Velasco, Yurie Kura, Barry R. Davies, Yuji Hatanaka, Hirotsugu Uemura, Kazuto Nishio

المصدر: JCI Insight. 4

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.drug_class, Antineoplastic Agents, Castration resistant, urologic and male genital diseases, Antiandrogen, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Pharmacotherapy, Antisense Oligonucleotide Therapy, Animals, Humans, Medicine, Pyrroles, Protein kinase B, PI3K/AKT/mTOR pathway, Mice, Knockout, business.industry, Prostatic Neoplasms, General Medicine, Oligonucleotides, Antisense, medicine.disease, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Androgen receptor, Disease Models, Animal, Prostatic Neoplasms, Castration-Resistant, Pyrimidines, 030104 developmental biology, Drug Resistance, Neoplasm, Receptors, Androgen, 030220 oncology & carcinogenesis, Cancer research, Transcriptome, business, Proto-Oncogene Proteins c-akt, Research Article, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8cf2bddeac4732db473566c0ff7ec1Test
https://doi.org/10.1172/jci.insight.122688Test

المؤلفون: Alison L. Bigley, Barry R. Davies, Daniel G. Rudmann, Stephanie Klein, Leigh Williams

المصدر: Toxicologic Pathology. 44:663-672

مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, Cell, H&E stain, Kinesins, Mitosis, Antineoplastic Agents, Biology, Toxicology, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Image Processing, Computer-Assisted, medicine, Animals, Humans, Molecular Biology, Carcinoma, Transitional Cell, Cell growth, Cell Biology, Cell cycle, medicine.disease, Xenograft Model Antitumor Assays, Rats, 030104 developmental biology, Transitional cell carcinoma, medicine.anatomical_structure, Urinary Bladder Neoplasms, 030220 oncology & carcinogenesis, Mitotic Figure, Immunohistochemistry, Algorithm, Algorithms

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247d553f4757996f3e63db7b65438105Test
https://doi.org/10.1177/0192623316629805Test

المؤلفون: Stephen Green, Sylvie Guichard, Robert McEwen, Barry R. Davies, Urszula M. Polanska, Zoe Howard, Teresa Klinowska, Celina M. D'Cruz, Michael Grondine, Christine M. Chresta, Teeru Bihani, Graham Bigley, James W.T. Yates, Kurt Gordon Pike, Jon Curwen, Sabina Cosulich, Oona Delpuech, Martin Pass

المصدر: Molecular Cancer Therapeutics. 14:2508-2518

مصطلحات موضوعية: Cancer Research, Morpholines, Immunoblotting, Breast Neoplasms, Mechanistic Target of Rapamycin Complex 2, Mice, SCID, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, Pharmacology, mTORC2, Drug Administration Schedule, Mice, Inbred NOD, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Fulvestrant, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Mice, Knockout, Serine/threonine-specific protein kinase, Estradiol, Cell growth, TOR Serine-Threonine Kinases, Xenograft Model Antitumor Assays, Tumor Burden, HEK293 Cells, Pyrimidines, Receptors, Estrogen, Oncology, Multiprotein Complexes, Benzamides, MCF-7 Cells, Hormonal therapy, Female, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689b8ba235f8b435652d9591e5d9196fTest
https://doi.org/10.1158/1535-7163.mct-15-0365Test

المؤلفون: Nicolas Floc'h, Jonathan Cairns, Maria Luisa Guerriero, Barry R. Davies, Natasha A. Karp, Antonio Ramos-Montoya

المصدر: Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 11, Iss 11 (2018)

مصطلحات موضوعية: 0301 basic medicine, Process (engineering), Computer science, Population studies, Population, Neuroscience (miscellaneous), lcsh:Medicine, Medicine (miscellaneous), Population based, Patient response, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Immunology and Microbiology (miscellaneous), lcsh:Pathology, Preclinical trial, Animals, Humans, False Positive Reactions, Resource Article, education, False Negative Reactions, Tumor xenograft, education.field_of_study, Drug discovery, lcsh:R, Dd, Xenograft Model Antitumor Assays, Treatment efficacy, Clinical trial, 030104 developmental biology, Treatment Outcome, Risk analysis (engineering), Patient-derived tumor xenografts, lcsh:RB1-214

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07527e4c60eef35286e774487f95ebffTest
https://pubmed.ncbi.nlm.nih.gov/30254068Test