المؤلفون: David Casadevall, Anna Hernández-Prat, Sara García-Alonso, Oriol Arpí-Llucià, Silvia Menéndez, Mengjuan Qin, Cristina Guardia, Beatriz Morancho, Francisco Javier Sánchez-Martín, Sandra Zazo, Elena Gavilán, Mohammad A. Sabbaghi, Pilar Eroles, Juan Miguel Cejalvo, Ana Lluch, Federico Rojo, Atanasio Pandiella, Ana Rovira, Joan Albanell

المساهمون: Instituto de Salud Carlos III, Generalitat de Catalunya, Ministerio de Economía y Competitividad (España), Fundación CRIS contra el Cáncer, China Scholarship Council, European Commission

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
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مصطلحات موضوعية: musculoskeletal diseases, Inhibition of mTOR increases the antitumor activity of T-DM1, congenital, hereditary, and neonatal diseases and abnormalities, Cancer Research, Immunoconjugates, Receptor, ErbB-2, TOR Serine-Threonine Kinases, Breast Neoplasms, Mechanistic Target of Rapamycin Complex 1, Trastuzumab, Ado-Trastuzumab Emtansine, Antibodies, Monoclonal, Humanized, Antibody-drug conjugates warrants clinical evaluation in patients with HER2-positive breast cancer, Xenograft Model Antitumor Assays, Mice, Supporting that the combination of mTOR inhibitors, Oncology, Cell Line, Tumor, Animals, Humans, Female, Everolimus, skin and connective tissue diseases, Molecular Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3656e1cb422ad1d2aa23e9ba81826192Test
http://hdl.handle.net/10261/282954Test

المؤلفون: Gabrielle Leclercq, Hélène Haegel, Alberto Toso, Tina Zimmermann, Luke Green, Nathalie Steinhoff, Johannes Sam, Vesna Pulko, Anneliese Schneider, Anna Maria Giusti, John Challier, Anne Freimoser-Grundschober, Laurent Larivière, Alex Odermatt, Martin Stern, Pablo Umana, Marina Bacac, Christian Klein

المصدر: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)

مصطلحات موضوعية: Pharmacology, Clinical/Translational Cancer Immunotherapy, Cancer Research, Immunology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, MTOR Inhibitors, cytokines, Mice, Oncology, Antibodies, Bispecific, Molecular Medicine, Immunology and Allergy, Animals, Humans, Janus Kinase Inhibitors, immunotherapy, RC254-282, T-lymphocytes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bdedc499d9b1ef08ee71d0adbd90fbTest
https://pubmed.ncbi.nlm.nih.gov/35064010Test

المؤلفون: Jun Sang, Sheng Yin, Ming-Feng Zou, Jia-Luo Huang, Zi-Jun Lin, Gui-Hua Tang, Lu Gan, Wei Li, Run-Zhu Fan

المصدر: Cancer letters. 526

مصطلحات موضوعية: MAPK/ERK pathway, Male, Cancer Research, Transfection, Paraptosis, Mice, Cell Line, Tumor, medicine, Autophagy, Animals, Humans, Protein kinase B, Bladder cancer, Everolimus, Chemistry, Cancer, MTOR Inhibitors, medicine.disease, Temsirolimus, Oncology, Urinary Bladder Neoplasms, Cancer research, Diterpenes, Proto-Oncogene Proteins c-akt, medicine.drug, Drugs, Chinese Herbal, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a31b0bbf74b43754d9a2d99aa3ad41bTest
https://pubmed.ncbi.nlm.nih.gov/34798195Test

المؤلفون: Takayoshi Suzuki, Gabrielle Gray, Rajeshwar Rao Tekmal, Yi He, Srinath Palakurthi, Sureshkumar Mulampurath Achuthan Pillai, Prabhakar Pitta Venkata, Zhao Lai, Junhao Liu, Edward R. Kost, Salvador Alejo, Suryavathi Viswanadhapalli, Ilanna Loeffel, Gangadhara R. Sareddy, Yi Zou, Bridgitte E. Palacios, Ratna K. Vadlamudi, Uday P. Pratap, Yihong Chen

المصدر: Cancer letters. 524

مصطلحات موضوعية: Male, Cancer Research, Cell Survival, medicine.medical_treatment, Apoptosis, mTORC2, Targeted therapy, Mice, Cell Movement, medicine, Animals, Humans, Viability assay, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Histone Demethylases, Sirolimus, Chemistry, TOR Serine-Threonine Kinases, MTOR Inhibitors, Xenograft Model Antitumor Assays, Endometrial Neoplasms, Gene Expression Regulation, Neoplastic, Oncology, Cancer research, Female, Drug Screening Assays, Antitumor, Chromatin immunoprecipitation, Ex vivo, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ad2d9424beea8ece843b299524d4ecTest
https://pubmed.ncbi.nlm.nih.gov/34673129Test

المؤلفون: Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell

المصدر: Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652Test

مصطلحات موضوعية: 0301 basic medicine, Eukaryotic Initiation Factor-4E/drug effects, Colorectal cancer, Mutant, mTORC1, Biology, medicine.disease_cause, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Animals, Humans, Protein Serine-Threonine Kinases/drug effects, Phosphorylation, neoplasms, Intracellular Signaling Peptides and Proteins/drug effects, MTOR Inhibitors/pharmacology, Mutation, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, EIF4E, Translation (biology), medicine.disease, Colorectal Neoplasms/genetics, digestive system diseases, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, KRAS

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3Test
https://doi.org/10.1158/2159-8290.CD-20-0652Test

المؤلفون: Judy S. Wang, Aimee Bence Lin, Wenjuan Wu, Kathleen N. Moore, Xuejing Aimee Wang, Gregory P. Donoho, Susanna Varkey Ulahannan, Manish R. Patel, Suzanne F. Jones, Johanna C. Bendell, Daniel D. Karp, Andrew Capen, David S. Hong, Yan Ding

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 27(7)

مصطلحات موضوعية: 0301 basic medicine, Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Pyridines, Triple Negative Breast Neoplasms, Neutropenia, Quinolones, 03 medical and health sciences, Mice, 0302 clinical medicine, Breast cancer, Internal medicine, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, CHEK1, Adverse effect, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Aged, Phosphoinositide-3 Kinase Inhibitors, Leukopenia, business.industry, MTOR Inhibitors, Middle Aged, medicine.disease, Primary tumor, 030104 developmental biology, 030220 oncology & carcinogenesis, Pyrazines, Toxicity, Checkpoint Kinase 1, Pyrazoles, Female, medicine.symptom, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa715e14c089a055c0a5c77de4aafffbTest
https://pubmed.ncbi.nlm.nih.gov/33495309Test

المؤلفون: Magali Haissaguerre, Bruno Vergès, Françoise Borson-Chazot, Frédéric Albarel, Sarra Smati, C. Cortet, Benjamin Bouillet, Philippe Caron, Christine Do Cao, Delphine Drui, Philippe Chanson, Frédéric Illouz, Frederic Castinetti, E. Merlen, Perrine Buffier, Emmanuelle Kuhn, Ségolène Hescot, Bertrand Cariou, Véronique Raverot, Olivier Chabre, Claire Briet, Najiba Lahlou, F. Archambeaud, Jérôme Bertherat

المساهمون: Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre de référence des maladies rares de l'hypophyse (HYPO), Service d'Endocrinologie, Diabète et Maladies Métaboliques, Service de Médecine interne B, Endocrinologie, Diabète, Maladies métaboliques [CHU Limoges], CHU Limoges, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'endocrinologie et maladies métaboliques (Hôpital Cochin), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Endocrinologie, Diabétologie et Maladies Métaboliques (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Biologie Neurovasculaire et Mitochondriale Intégrée (BNMI), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Service d’Endocrinologie Diabétologie Nutrition [CHU Angers), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service d'Endocrinologie [Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service d'endocrinologie, maladies métaboliques et nutrition (CHU de Toulouse), CHRU Toulouse, Service d'endocrinologie-diabétologie-nutrition [CHU Grenoble-Alpes], Centre Hospitalier Universitaire Grenoble Alpes (CHU Grenoble Alpes), Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service d'Endocrinologie et des Maladies de la Reproduction [AP-HP Hôpital de Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service d’endocrinologie, diabétologie et maladies métaboliques [CHRU LIlle], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Physiopathologie de la plasticité neuronale, Université Bordeaux Segalen - Bordeaux 2, Service d'endocrinologie, diabétologie et nutrition (CHU de Bordeaux), CHU Bordeaux [Bordeaux], Institut Curie [Paris], Service d'Endocrinologie, Diabétologie et Nutrition [CHU Angers], Service de Biochimie et Biologie moléculaire [CH Lyon Sud], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Fédération d'Endocrinologie, Hospices Civils de Lyon (HCL), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Unité de recherche de l'institut du thorax (ITX-lab), Service Endocrinologie, maladies métaboliques et nutrition [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire [Grenoble] (CHU), CHU Toulouse [Toulouse]

المصدر: Annales d'Endocrinologie
Annales d'Endocrinologie, Elsevier Masson, 2018, 79 (5), pp.591-595. ⟨10.1016/j.ando.2018.07.005⟩
Annales d'Endocrinologie, 2018, 79 (5), pp.591-595. ⟨10.1016/j.ando.2018.07.005⟩

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Consensus, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Antineoplastic Agents, 030209 endocrinology & metabolism, [SDV.CAN]Life Sciences [q-bio]/Cancer, Endocrine System Diseases, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Dysthyroidism, Neoplasms, Internal medicine, Animals, Humans, Medicine, Endocrine system, Hypophysitis, Adverse effect, MTOR inhibitors, Tyrosine kinase inhibitors, Adrenal failure, business.industry, Diabetes, General Medicine, Immunotherapy, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Discovery and development of mTOR inhibitors, 3. Good health, Dyslipidemia, Anticancer treatment, 030220 oncology & carcinogenesis, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9539fd7d895aef98ddd45ac681fecfcTest
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01979955Test

المؤلفون: Tsuneo Saga, Winn Aung, Atsushi B. Tsuji, Tatsuya Higashi, Takako Furukawa, Yoshikazu Kurosawa, Aya Sugyo, Yoshinori Ukai, Hitomi Sudo, Katsushi Kouda

المصدر: World Journal of Gastroenterology

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Yttrium-90, medicine.medical_treatment, Mice, Nude, Antineoplastic Agents, Integrin alpha6, 03 medical and health sciences, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Combined treatment, Internal medicine, Pancreatic cancer, Cell Line, Tumor, medicine, Animals, Humans, Yttrium Radioisotopes, PI3K/AKT/mTOR pathway, business.industry, Anti-integrin α6β4 antibody, Integrin beta4, Gastroenterology, Imidazoles, Antibodies, Monoclonal, General Medicine, Basic Study, Radioimmunotherapy, medicine.disease, Discovery and development of mTOR inhibitors, Xenograft Model Antitumor Assays, NVP-BEZ235, Pancreatic Neoplasms, 030104 developmental biology, 030220 oncology & carcinogenesis, Quinolines, Female, business, Proto-Oncogene Proteins c-akt, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57e70b20205353d38f0cdc6ccaf2846Test
http://europepmc.org/articles/PMC5698248Test

المؤلفون: Zatelli, Maria Chiara, Fanciulli, Giuseppe, Malandrino, Pasqualino, NIKE GROUP: Albertelli M, Arvat E, Baldelli R, Berruti A, Bianchi A, Bodei L, Botti G, Corcione F, Daví MV, Delle Fave G, De Marinis L, Di Sarno A, Dicitore A, Fazio N, Ferolla P, Ferone D, Filice A, Gallo M, Giordano C, Giuffrida D, Guarnotta V, Lania A, Lastoria S, Logoluso F, Loli P, Manzoni M, Marchetti M, Martini C, Messina E, Modica R, Motta C, Papotti M, Partelli S, Persico G, Pia A, Piovesan A, Pontecorvi A, Razzore P, Rota F, Scavuzzo F, Sciammarella C, Vitale G., RAMUNDO, VALERIA, FAGGIANO, ANTONGIULIO, COLAO, ANNAMARIA, DE ROSA, GAETANO

المساهمون: Zatelli, M, Fanciulli, G, Malandrino, P, Ramundo, V, Faggiano, A, Colao, A, Giordano, C, Zatelli, Mc, Nike, Group, Partelli, S, Zatelli, Maria Chiara, Fanciulli, Giuseppe, Malandrino, Pasqualino, Ramundo, Valeria, Faggiano, Antongiulio, Colao, Annamaria, NIKE GROUP: Albertelli, M, Arvat, E, Baldelli, R, Berruti, A, Bianchi, A, Bodei, L, Botti, G, Corcione, F, Daví, Mv, Delle Fave, G, De Marinis, L, DE ROSA, Gaetano, Di Sarno, A, Dicitore, A, Fazio, N, Ferolla, P, Ferone, D, Filice, A, Gallo, M, Giuffrida, D, Guarnotta, V, Lania, A, Lastoria, S, Logoluso, F, Loli, P, Manzoni, M, Marchetti, M, Martini, C, Messina, E, Modica, R, Motta, C, Papotti, M, Persico, G, Pia, A, Piovesan, A, Pontecorvi, A, Razzore, P, Rota, F, Scavuzzo, F, Sciammarella, C, Vitale, G.

المصدر: Endocrine-Related Cancer. 23:R173-R183

مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, mTOR inhibitor, Endocrinology, Diabetes and Metabolism, Neuroendocrine tumors, Antineoplastic Agent, 0302 clinical medicine, Endocrinology, Neuroendocrine tumours, neuroendocrine tumour, Treatment resistance, MTOR inhibitors, Tumor, Medical treatment, TOR Serine-Threonine Kinases, Discovery and development of mTOR inhibitors, Response to treatment, Patient management, Diabetes and Metabolism, Neuroendocrine Tumors, 030220 oncology & carcinogenesis, Neuroendocrine Tumor, Human, Predictors, Animals, Antineoplastic Agents, Biomarkers, Tumor, Diagnostic Imaging, Humans, Protein Kinase Inhibitors, medicine.medical_specialty, Protein Kinase Inhibitor, Early detection, predictor, Biology, NO, 03 medical and health sciences, mTOR inhibitors, neuroendocrine tumours, predictors, response to treatment, Internal medicine, medicine, mTOR inhibitors,neuroendocrine tumours,predictors,response to treatment, mTOR inhibitors, neuroendocrine tumours, predictors, response to treatment, Animal, medicine.disease, 030104 developmental biology, Immunology, Biomarkers, Resource utilization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6655e53dd15554bad67e602ff7f2473Test
https://doi.org/10.1530/erc-15-0413Test

المؤلفون: Ji Nie, Xuelei Ma, Jing Yang, Xiawei Wei, Yong Peng, Yuquan Wei

المصدر: Molecular Cancer
Molecular Cancer, Vol 18, Iss 1, Pp 1-28 (2019)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Antineoplastic Agents, Review, Biology, lcsh:RC254-282, PI3K signaling, PI3K, Target therapy, 03 medical and health sciences, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Neoplasms, medicine, Animals, Humans, Molecular Targeted Therapy, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cancer, Phosphoinositide-3 Kinase Inhibitors, Clinical Trials as Topic, TOR Serine-Threonine Kinases, Master regulator, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Discovery and development of mTOR inhibitors, Clinical trial, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Tumor progression, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, mTOR, Molecular Medicine, Proto-Oncogene Proteins c-akt, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760fbcdfb07da0c9e7201f544add6b61Test
http://europepmc.org/articles/PMC6379961Test