Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2
| العنوان: | Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2 |
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| المؤلفون: | Nitin Kamble, Angila Gurung, Benedikt B. Kaufer, Ansar Ahmed Pathan, Shahriar Behboudi |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | congenital, hereditary, and neonatal diseases and abnormalities, 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche, animal structures, T-Lymphocytes, animal diseases, viruses, Immunology, COX2 = cyclooxygenase 2, Lymphocyte Activation, Marek’s disease virus, Dinoprostone, T cell proliferation, hemic and lymphatic diseases, Immune Tolerance, Marek Disease, Animals, Immunology and Allergy, Herpesvirus 2, Gallid, Cell Proliferation, Original Research, immunosuppression, virus diseases, RC581-607, Marek���s disease virus, Enzyme Activation, Cyclooxygenase 2, cyclooxygenase 2 (COX2), PGE2, Immunologic diseases. Allergy, Chickens |
| الوصف: | Copyright © 2021 Kamble, Gurung, Kaufer, Pathan and Behboudi. Marek’s disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection. However, the exact mechanisms involved in MDV-induced immunosuppression are yet to be identified. Here, our results demonstrate that MDV infection in vitro and in vivo induces activation of cyclooxygenase-2 (COX-2) and production of prostaglandin E2 (PGE2). This exerts its inhibitory effects on T cell proliferation at day 21 post infection via PGE2 receptor 2 (EP2) and receptor 4 (EP4). Impairment of the MDV-induced T cell proliferation was associated with downregulation of IL-2 and transferrin uptake in a COX-2/PGE2 dependent manner in vitro. Interestingly, oral administration of a COX-2 inhibitor, meloxicam, during MDV infection inhibited COX-2 activation and rescued T cell proliferation at day 21 post infection. Taken together, our results reveal a novel mechanism that contributes to immunosuppression in the MDV-infected chickens. U.K. Research and Innovation Biotechnology and Biological Sciences Research Council Grants BBS/E/I/00001825, BBS/E/I/00007030, BBS/E/I/00007031, BB/S01506X/1, BBS/E/I/00002529, BBS/E/I/00007039, BBS/E/I/00007032, BB/N002598/1 and BB/V019031/1. |
| وصف الملف: | Electronic |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a38ff0ac8093bc1a558703939707992Test http://europepmc.org/articles/PMC8727754Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3a38ff0ac8093bc1a558703939707992 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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