Animal Models of Neointimal Hyperplasia and Restenosis
| العنوان: | Animal Models of Neointimal Hyperplasia and Restenosis |
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| المؤلفون: | Melanie A. Kimm, Vanessa Franziska Schmidt, Max L.A. Ebert, Lena Pfaff, Anne von Thaden, Moritz Wildgruber |
| المصدر: | JACC: Basic to Translational Science |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Vascular smooth muscle, medicine.medical_treatment, HDL, high-density lipoprotein, Cell, neointimal hyperplasia, Bioinformatics, PDGF, platelet-derived growth factor, VSMC, vascular smooth muscle cell, Fibroblast migration, restenosis, Restenosis, LDL, low-density lipoprotein, Angioplasty, medicine, VLDL, very low-density lipoprotein, TGF, transforming growth factor, Neointimal hyperplasia, business.industry, animal model, angioplasty, Stent, Lipid metabolism, medicine.disease, ECM, extracellular matrix, FGF, fibroblast growth factor, CETP, cholesteryl ester transferase protein, LDLr, LDL receptor, medicine.anatomical_structure, Apo, apolipoprotein, State-of-the-Art Review, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Central Illustration Highlights • Neointimal hyperplasia is the major factor contributing to restenosis after angioplasty procedures. • Multiple animal models exist to study basic and translational aspects of restenosis formation. • Animal models differ substantially, and species-specific differences have major impact on the pathophysiology of the model. • Genetic, dietary, and mechanical interventions determine the translational potential of the animal model used and have to be considered when choosing the model. Summary The process of restenosis is based on the interplay of various mechanical and biological processes triggered by angioplasty-induced vascular trauma. Early arterial recoil, negative vascular remodeling, and neointimal formation therefore limit the long-term patency of interventional recanalization procedures. The most serious of these processes is neointimal hyperplasia, which can be traced back to 4 main mechanisms: endothelial damage and activation; monocyte accumulation in the subintimal space; fibroblast migration; and the transformation of vascular smooth muscle cells. A wide variety of animal models exists to investigate the underlying pathophysiology. Although mouse models, with their ease of genetic manipulation, enable cell- and molecular-focused fundamental research, and rats provide the opportunity to use stent and balloon models with high throughput, both rodents lack a lipid metabolism comparable to humans. Rabbits instead build a bridge to close the gap between basic and clinical research due to their human-like lipid metabolism, as well as their size being accessible for clinical angioplasty procedures. Every different combination of animal, dietary, and injury model has various advantages and disadvantages, and the decision for a proper model requires awareness of species-specific biological properties reaching from vessel morphology to distinct cellular and molecular features. |
| تدمد: | 2452-302X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88165634a122d3faf899cdcac81ed099Test https://doi.org/10.1016/j.jacbts.2021.06.006Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....88165634a122d3faf899cdcac81ed099 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2452302X |
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