Animal models of major depressive disorder and the implications for drug discovery and development
| العنوان: | Animal models of major depressive disorder and the implications for drug discovery and development |
|---|---|
| المؤلفون: | Demin, K. A., Sysoev, M., Chernysh, M. V., Savva, A. K., Koshiba, M., Wappler-Guzzetta, E. A., Song, C., De Abreu, M. S., Leonard, B., Parker, M. O., Harvey, B. H., Tian, L., Vasar, E., Strekalova, T., Amstislavskaya, T. G., Volgin, A. D., Alpyshov, E. T., Wang, D., Kalueff, A. V. |
| المصدر: | Expert Opin. Drug. Discov. Expert Opinion on Drug Discovery |
| بيانات النشر: | Taylor and Francis Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | MAJOR DEPRESSIVE DISORDER, DISEASE MODELS, ANIMAL, ANIMAL MODELING, PATHOGENESIS, PATHOPHYSIOLOGY, TRANSLATIONAL RESEARCH, ANIMALS, HUMAN, HUMANS, MAJOR DEPRESSION, ANIMAL, ANIMAL MODEL, DEPRESSION, DISEASE MODEL, ANTIDEPRESSIVE AGENTS, DEPRESSIVE DISORDER, MAJOR, DRUG DISCOVERY, ANTIDEPRESSANT AGENT, ENDOPHENOTYPE, TRANSLATIONAL MEDICAL RESEARCH, PROCEDURES, NONHUMAN, REVIEW, PRIORITY JOURNAL, DRUG DEVELOPMENT |
| الوصف: | Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is often treatment-resistant and recurrent, necessitating the development of novel therapies, models and concepts in this field. Areas covered: Animal models are indispensable for translational biological psychiatry, and markedly advance the study of depression. Novel approaches continuously emerge that may help untangle the disorder heterogeneity and unclear categories of disease classification systems. Some of these approaches include widening the spectrum of model species used for translational research, using a broader range of test paradigms, exploring new pathogenic pathways and biomarkers, and focusing more closely on processes beyond neural cells (e.g. glial, inflammatory and metabolic deficits). Expert opinion: Dividing the core symptoms into easily translatable, evolutionarily conserved phenotypes is an effective way to reevaluate current depression modeling. Conceptually novel approaches based on the endophenotype paradigm, cross-species trait genetics and ‘domain interplay concept’, as well as using a wider spectrum of model organisms and target systems will enhance experimental modeling of depression and antidepressant drug discovery. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=od_______917::9d62527b98ae0d7d7a84d8918c62ce3bTest https://hdl.handle.net/10995/101790Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.od.......917..9d62527b98ae0d7d7a84d8918c62ce3b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |