دورية أكاديمية
Development of a Model of Pediatric Lung Failure Pathophysiology
| العنوان: | Development of a Model of Pediatric Lung Failure Pathophysiology |
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| المؤلفون: | Trahanas, John M., Alghanem, Fares, Ceballos-Muriel, Catalina, Hoffman, Hayley R., Xu, Alice, Deatrick, Kristopher Barry, Cornell, Marie S., Rojas-Pena, Alvaro, Bartlett, Robert H. |
| بيانات النشر: | Wolters Kluwer Health ASAIO Journal |
| مصطلحات موضوعية: | Prótesis e implantes, Mortalidad del niño, trasplante de pulmón, lung failure, Animal mode, Pulmonary hypertension |
| الوصف: | A pediatric artificial lung (PAL) is under development as a bridge to transplantation or lung remodeling for children with end-stage lung failure (ESLF). To evaluate the efficiency of a PAL, a disease model mimicking the physiologic derangements of pediatric ESLF is needed. Our previous right pulmonary artery (rPA) ligation model (rPA-LM) achieved that goal, but caused immediate mortality in nearly half of the animals. In this study, we evaluated a new technique of gradual postoperative right pulmonary artery occlusion using a Rummel tourniquet (rPA-RT) in seven (25–40 kg) sheep. This technique created a stable model of ESLF pathophysiology, characterized by high alveolar dead space (58.0% ± 3.8%), pulmonary hypertension (38.4 ± 2.2 mm Hg), tachypnea (79 ± 20 breaths per minute), and intermittent supplemental oxygen requirement. This improvement to our technique provides the necessary physiologic derangements for testing a PAL, whereas avoiding the problem of high immediate perioperative mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1538-943X |
| العلاقة: | ASAIO Journal, 1538-943X, Vol. 63, Nro. 2, 2017, p. 216-222; https://journals.lww.com/asaiojournal/Fulltext/2017/03000/Development_of_a_Model_of_Pediatric_Lung_Failure.18.aspxTest; http://hdl.handle.net/20.500.12495/3436Test; https://doi.org/10.1097/mat.0000000000000463Test; instname:Universidad El Bosque; reponame:Repositorio Institucional Universidad El Bosque; https://repositorio.unbosque.edu.coTest |
| DOI: | 10.1097/mat.0000000000000463 |
| الإتاحة: | https://doi.org/20.500.12495/3436Test https://doi.org/10.1097/mat.0000000000000463Test https://hdl.handle.net/20.500.12495/3436Test https://repositorio.unbosque.edu.coTest |
| حقوق: | Acceso abierto ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess ; 2017-04 |
| رقم الانضمام: | edsbas.C2949D03 |
| قاعدة البيانات: | BASE |
| تدمد: | 1538943X |
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| DOI: | 10.1097/mat.0000000000000463 |