التفاصيل البيبلوغرافية
| العنوان: |
Effect of Priming With Seasonal Influenza A(H3N2) Virus on the Prevalence of Cross-Reactive Hemagglutination-Inhibition Antibodies to Swine-Origin A(H3N2) Variants. |
| المؤلفون: |
Feng Liu, Veguilla, Vic, Gross, F. Liaini, Gillis, Eric, Rowe, Thomas, Xiyan Xu, Tumpey, Terrence M., Katz, Jacqueline M., Levine, Min Z., Xiuhua Lu, Liu, Feng, Xu, Xiyan, Lu, Xiuhua |
| المصدر: |
Journal of Infectious Diseases; 2017 Supplement, Vol. 216, pS539-S547, 9p |
| مصطلحات موضوعية: |
INFLUENZA A virus, H3N2 subtype, BLOOD agglutination, SWINE diseases, ANTIBODY formation, DISEASE prevalence, INFLUENZA epidemiology, ANIMAL experimentation, ANTIGEN-antibody reactions, EPIDEMIOLOGICAL research, HEMAGGLUTINATION tests, INFLUENZA, MAMMALS, RESEARCH funding, SWINE, VIRAL antibodies, VIRAL antigens, ORTHOMYXOVIRUS infections |
| مستخلص: |
Background: Recent outbreaks of swine-origin influenza A(H3N2) variant (H3N2v) viruses have raised public health concerns. Previous studies indicated that older children and young adults had the highest levels of hemagglutination-inhibition (HI) antibodies to 2010-2011 H3N2v viruses. However, newly emerging 2013 H3N2v have acquired antigenic mutations in the hemagglutinin at amino acid position 145 (N145K/R). We estimated the levels of serologic cross-reactivity among humans primed with seasonal influenza A(H3N2) (sH3N2), using postinfection ferret antisera. We also explored age-related HI antibody responses to 2012-2013 H3N2v viruses.Methods: Human and ferret antisera were tested in HI assays against 1 representative 2012 H3N2v (145N) and 2 2013 H3N2v (145K/R) viruses, together with 9 sH3N2 viruses circulating since 1968.Results: Low levels of cross-reactivity between the H3N2v and sH3N2 viruses from the 1970s-1990s were observed using postinfection ferret antisera. The overall seroprevalence among the sH3N2-primed population against 2012-2013 H3N2v viruses was >50%, and age-related seroprevalence was observed. Seroprevalence was significantly higher to 2013 H3N2v than to 2012 H3N2v viruses among some children likely to have been primed with A/Sydney/5/97-like (145K) or A/Wuhan/359/95-like viruses (145K).Conclusions: A single substitution (N145K/R) was sufficient to affect seropositivity to H3N2v viruses in some individuals. Insight into age-related antibody responses to newly emerging H3N2v viruses is critical for risk assessment and pandemic preparedness. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
