التفاصيل البيبلوغرافية
العنوان:
Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes
المؤلفون:
Parving, Hh , Brenner, Bm , Mcmurray, Jj , de Zeeuw, D , Haffner, Sm , Solomon, Sd , Chaturvedi, N , Persson, F , Desai, As , Nicolaides, M , Richard, A , Xiang, Z , Brunel, P , Pfeffer, Ma , Viberti, G , Lachin, Jm , Zinman, B , Pedersen, Tr , Villamil, As , Juncos, L , Prager, R , Verpooten, G , Zanella, Mt , Leiter, L , Pan, C , Wang, H , Botero, R , Cifkova, R , Christiansen, Js , Groop, Ph , Marre, M , Haller, H , Nickenig, G , Siamopoulos, K , Gero, L , Maggioni, A , Remuzzi, G , Katayama, Ss , Kim, Sg , Petrulioniene, Z , Lok, D , Kooy, A , Jorde, R , Medina, F , Polonia, J , Wong, Ks , Dukat, A , Rayner, Bl , Ruilope, L , Weiss, L , Wuethrich, R , Sheu, W , Sritara, P , Comlekci, A , Bilous, R , Toto, R , Jamerson, K , Carillo, E , Orias, M , Kuschnir, E , Rusculleda, M , Garcia, S , Farias, E , Lema, L , Hominal, M , Montaña, O , Sala, J , Diaz, M , Piskorz, D , Vita, N , Litwak, L , Sinay, I , Marin, M , Massari, P , Majul, C , Aizemberg, D , Azize, Gm , Bartolacci, I , Reboredo, A , Vico, M , Milesi, R , Sessa, H , Wassermann, A , Margulis, F , Zangroniz, P , Watschinger, B , Toplak, H , Paulweber, B , Drexel, H , Francesconi, C , Foeger, B , Mayer, G , Braun, Rk , Brath, H , Gaal, Lv , Niepen, Pv , Persu, A , Vercammen, C , Vriese, Ad , Coucke, F , Mathieu, C , Fery, F , Treille, S , Meeus, G , Acker, Kv , Scheen, A , Tits, J , Ruige, J , Krzesinski, Jm , Hollanders, G , Liénart, F , Dendale, P , Quinonez, M , Arnouts, P , Vanuytsel, J , Zanella, M , Mion D., Jr , Forti, A , Almeida, F , Cunha, R , de Paula RB , Brandao, A , Rocha, J , Krieger, E , Feitosa, G , Saraiva, J , Martin, J , Hissa, Mn , Schmid, H , Felicio, J , Sgarbi, J , Oigman, W , Bowering, K , Garceau, C , Berlingieri, Jc , Weisnagel, Sj , Hardin, P , Powell, C , Turcot, R , Muirhead, N , Aronson, R , Barima, Yt , Steele, Aw , Pandey, S , Woo, V , Cha, J , Dattani, D , Godin, C , Gupta, M , Saunders, K , Tellier, G , Ting, R , Tobe, S , Chouinard, G , Schlosser, R , Khandwala, H , Ekoe, Jm , Harris, Sb , Pichette, V , Lachance, P , Ooi, Tc , Tildesley, H , Barrett, B , Cournoyer, S , Lu, J , Zhang, H , Liu, X , Yan, S , Qi, X , Li, Q , Li, H , Lv, X , Yang, J , Sun, N , Xia, W , Wang, N , Tong, N , Mei, C , Gu, S , Zhang, J , Chen, X , Li, L , Su, B , Wang, L , Qiu, M , Wu, X , Liu, Z , Jia, W , Xu, G , Dong, J , Zhu, D , Zhang, M , Yan, J , Liu, B , Chen, J , Fu, J , Yan, L , Zhan, X , Zhong, L , Yang, T , Ma, J , Xu, M , Xu, X , Shi, B , Ji, Q , Zhong, H , He, R , Yuan, Z , Zhou, Z , Lin, H , Yang, W , Ke, Y , Hong, T , Franco, C , Casas, L , Triana, A , Jaramillo, C , Hernandez, E , Barrera, C , Blanco, D , Stipal, R , Widimsky, P , Dohnalova, L , Komroskova, M , Kvapil, M , Belobradkova, J , Tesar, V , Vodnansky, P , Kocourkova, B , Lervang, Hh , Perrild, H , Rossing, P , Oestergaard, O , Juhl, H , Thorsteinsson, B , Snorgaard, O , Urhammer, S , Egstrup, K , Tikkanen, T , Helin, K , Rinne, J , Lahtela, J , Strand, J , Valtonen, E , Saari, M , Kananen, K , Savela, K , Blacher, J , Aldigier, Jc , Zaoui, P , Fauvel, Jp , Gouet, D , Valensi, Pe , Charpentier, G , Marechaud, R , Penfornis, A , Ovize, M , Kovalchuck, Aa , Dellanna, F , Schoen, N , Groeschel, W , Eickhoff, F , Hanefeld, M , Merke, J , Rambausek, M , Zimmermann, U , Stuetz, W , Vosskuehler, A , Hevendehl, G , Schax, U , Lehmann, G , Haack, A , Hilgenberg, J , Klausmann, G , Adelberger, V , Gessner, S , Fiesselmann, A , Oerter, E , Hohenstatt, T , Groeschel, A , Behnke, T , Sisting, Rt , Schoch, D , Bieler, T , Schleyer, S , Altes, U , Klepzig, C , Rudofsky, G , Mueller, G , Burkhardt, F , Reschke, K , Senftleber, I , Wiesweg, Ck , Herrmann, Hj , Brandstetter, R , Segner, A , Schmitt, H , Rippert, R , Goebel, R , Schreibmueller, F , Pencz, I , Ott, P , Migdalis, I , Pappas, S , Pagkalos, E , Yalouris, A , Tsapas, A , Maltezos, E , Tentolouris, N , Papadakis, I , Ioannidis, G , Goumenos, D , Corona, V , Gonzalez, R , Haase, F , Monterroso, V , Sánchez, V , Turcios, E , Wyss, F , Arango, Jl , Bako, B , Deak, L , Dömötör, E , Dudas, M , Fulop, T , Kiss, I , Koranyi, L , Lengyel, Z , Nyirati, G , Oroszlan, T , Aniko, S , Vörös, P , Kapocsi, J , Wittmann, I , Paragh, G , Abraham, G , Tandon, N , Thomas, N , Mohan, V , Sahay, R , Sethi, B , Rao, V , Kumar, S , Chowdhury, S , Dharmalingam, M , Seshiah, V , Bantwal, G , Viswanathan, V , Yajnik, C , Adhikari, P , Krishnan, U , Varthakavi, P , Hiremath, J , Bhattacharyya, A , Dani, S , Modi, Kk , Glorioso, N , Morosetti, M , Veglio, Franco , Perticone, F , Dotta, F , Quarello, F , Sesti, G , Aiello, A , D'Ospina, A , Giordano, C , Novo, S , Santoro, A , Ferri, C , Capuano, V , Trimarco, B , Tonolo, G , Villa, G , De Pellegrin, A , Zanette, G , Federici, M , Aucello, G , Piatti, P , Vinciguerra, A , Mannarino, E , Taddei, S , Filetti, S , Grandaliano, G , Marchionni, N , Lambiase, C , Locatelli, F , Scanferla, F , Lembo, G , Leotta, S , Mos, L , Calatola, P , Fogari, R , David, S , Pedrinelli, R , Pignone, Am , Cozzolino, D , Bevilacqua, Mt , Catena, C , Del Prato, S , Cerasola, G , Frontoni, S , Falcone, C , Porta, A , Bonora, E , Cocchi, R , Fucili, A , Frisinghelli, A , Volpe, M , Carugo, S , Gambardella, S , Spagnuolo, V , Maglia, G , D'Angelo, Ar , Corsi, A , Limone, Pp , Guarnieri, A , Ghigo, Ezio , Ronchi, E , Ravera, M , Scioli, Ga , Sekiguchi, M , Aoki, S , Ogawa, Y , Seino, H , Onishi, Y , Tojo, A , Narimiya, M , Iwaita, Y , Takeda, H , Shimizu, H , Yamada, T , Kojima, S , Zushi, S , Kaneko, S , Matsumoto, A , Kajiyama, S , Fujita, H , Shikata, K , Tone, A , Matsubayashi, S , Tanaka, S , Sekigami, T , Tatsukawa, Y , Abe, N , Kawahara, K , Kasahara, H , Maeda, Y , Suzuki, Y , Okamoto, H , Tachi, K , Yamada, K , Uzu, T , Itou, T , Fukui, T , Kim, S , Kim, Y , Cho, W , Kwak, I , Chae, D , Oh, H , Ha, S , Shin, Y , Cha, D , Kang, S , Lim, C , Song, J , Kwon, Y , Badariene, J , Labutiniene, Ip , Zabuliene, L , Poteliuniene, V , Miglinas, M , van den Meiracker AH , Gregoor, Pj , Luik, Aj , van Loon BJ , Feenstra, Hj , Kaasjager, Ha , Viergever, Pp , Woittiez, Aj , van Bemmel, T , Lieverse, Ag , Simsek, S , Gaillard, Ca , van der Zwaan, C , Lok, Dj , Spiering, W , Nierop, Pr , Baggen, Mg , Leendert, Rj , de Jong, A , Leurs, Pb , Vincent, Hh , Wins, Eh , Voors, Aa , Ronner, E , Heeg, Je , van Hal JM , Boermans, T , Feis, Wl , Mostard, G , Bakker, Rc , Dunselman, Ph , Skeie, S , Istad, H , Skjelvan, G , Gronert, J , Tomala, T , Gudnason, S , Torvik, Dt , Risberg, K , Abedini, S , Cabrera, W , Medina, B , Herrada, B , Saavedra, A , Polonia, Dj , Providencia, Dl , Carvalho, D , Vasconcelos, Mp , da Silva GF , Branco, P , Gil, Dv , da Costa AG , da Silva PM , Arez, L , Martins, L , Birne, R , Dzuponova, J , Surovcikova, M , Culak, J , Filipova, S , Andre, I , Stevlik, J , Uhliar, R , Fabryova, L , Benacka, J , Koleny, D , Szentivanyi, M , Spisak, V , Pella, D , Pastrnakova, E , Martinka, E , Chua, T , Lau, T , Ng, Tg , Yeoh, Ly , Bhana, Sa , Rayner, B , Wellmann, H , Amod, A , Ranjith, N , Ahmed, F , Rheeder, P , Makan, H , Naicker, P , Podgorski, G , De Teresa, E , Olivan, J , Fernandez, Vl , Povedano, St , Terns, M , Ricart, W , Gonzalez, Jm , Fernandez, P , Parreño Lde, T , Redon, J , Parra, J , Calvo, C , Lopez, I , Puig, Jg , Calle, A , Garcia, Jc , Lopez, Jm , Jimenez, Ml , Fraile, B , Perez, Js , Nadal, Jj , Guija, E , Calviño, J , Barrios, V , Iglesias, Jn , Armario, P , Garcia, M , Aranda, P , Brotons, C , Gomez, P , Catelao, Am , Cusachs, Ar , Sarro, M , Martinez, V , dell Valle MH , Trias, F , Comas, A , Salvador, N , Martinez, F , Hernandez, F , Martinez, J , Mateos, C , Peral, Jl , Tolosana, J , Sobrino, J , Isart, J , Vizcaino, J , Vega, Ff , Zamorano, Jl , Bacariza, M , Soubriet, A , Fernández Cruz, A , Querejeta, R , Leira, Vm , Iglesias, Fe , Ibrik, O , Martin, D , Nanclares, Ms , Mediavilla, Jd , Galceran, Jm , Lopez, A , Muros, T , Pascual, J , Casalla, F , Tornero, F , Fernandez, G , Pettersson, P , Olsen, H , Franke, F , Stroembom, U , Furuland, H , Larnefelt, H , Allemann, Y , Krapf, R , Gerber, P , Munger, R , Hayoz, D , Graf, Hj , Burnier, M , Petrillo, A , Batt, R , Constam, En , Moccetti, T , Bianda, T , Rickli, H , Bulliard, C , Wu, Kd , Lin, Sh , Wu, Cj , Sheu, Wh , Su, Sl , Chen, Sc , Chou, Cw , Lee, Ct , Yang, Tc , Chen, Hc , Sukonthasarn, A , Sriratanasathavorn, C , Eiam Ong, S , Supasyndh, O , Chanchairujira, T , Kitiyakara, C , Arici, M , Usalan, C , Guneri, S , Koc, M , Kalender, B , Ates, K , Gurgun, C , Araz, M , Demirbas, B , Biernacki, W , Calvert, J , Eavis, P , Kerrane, J , Litchfield, J , Middleton, A , Roberts, J , Simpson, H , Charles, H , Jardine, A , Fisher, M , Banerjee, D , Gallen, I , Gnudi, L , Harvey, J , O'Hare, P , Vora, J , Winocour, P , Soran, H , Browne, D , Darko, D , Mancebo, Jg , de Roa ER , Antepara, N , Carrillo, E , Berrizbeitia, M , Guevara, L , Pernalete, N , Ontiveros, C , Zigrang, W , Blakney, E , Rosenblit, P , Weinstein, R , Klaff, L , Lipetz, R , Busick, E , Tung, P , Cooperman, M , Michael, S , Sun, Ch , Hart, T , Maddux, A , Bowden, R , East, C , Arakaki, R , Villafuerte, B , Mamish, Z , Mendez, R , Connery, L , Nour, K , Wynne, A , Busch, R , Zamora, B , Sachson, R , Prasad, J , Lasala, G , Smith, M , Fitz Patrick, D , Ruiz Rivera, L , Barranco, E , Solomon, R , Woolley, A , Brown, C , Freedman, Z , Schmidt, S , Pollock, J , Ruddy, M , Kopyt, Np , Bazzi, A , Horowitz, B , Feng, W , Wahl, T , Duprez, D , Gilbert, J , Steigerwalt, S , Jacqmein, J , Gorton, S , 3rd, Allison J. , Pino, J , Lock, J , Leimbach, W , Anderson, J , Beacom, M , Craig, W , Gorson, D , Kerstein, H , Segal, S , Downey, H , Ledger, G , Mcgill, J , Gabriel, J , Nolen, T , Levinson, L , Williams, T , Levenson, D , Lerman, S , Minehart, C , Agarwal, N , Verma, S , Valitutto, M , Demetry, K , Mersey, J , Koeper, D , Fanti, P , Eng, G , Grimm, R , Fagan, T , Bajaj, M , Katz, L , Portnay, G , Altschuller, A , Desai, V , Bilazarian, S , Ipp, E , Rodelas, R , Burstein, D , Berg, J , Velez, J , Lund, R , Rekhi, A , Martin, E , Robertson, D , Singh, N , Narayan, P , Moustafa, M , Lanier, D , Seidner, M , Phillips, A , Vaughters, B , Sprague, A , Swartz, S , Lopez, R , Kumar, J , Bressler, P , Sadler, L , Wise, J , Kilbane, A.
المساهمون:
Groningen Kidney Center (GKC)
المصدر:
Parving, Hans-Henrik; Brenner, Barry M.; McMurray, John J.V.; de Zeeuw, Dick; Haffner, Steven M.; Solomon, Scott D.; Chaturvedi, Nish; Persson, Frederik; Desai, Akshay S.; Nicolaides, Maria; Richard, Alexia; Xiang, Zhihua; Brunel, Patrick; Pfeffer, Marc A.; for the ALTITUDE, incl.; Allemann, Yves (2012). Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes. New England journal of medicine NEJM, 367(23), pp. 2204-2213. Waltham, Mass.: Massachusetts Medical Society MMS 10.1056/NEJMoa1208799 <http://dx.doi.org/10.1056/NEJMoa1208799Test >https://doi.org/10.1056/NEJMoa1208799Test
بيانات النشر:
Massachusetts Medical Society MMS, 2012.
سنة النشر:
2012
مصطلحات موضوعية:
Male , Hyperkalemia , CARDIOVASCULAR MORTALITY , BLOOD-PRESSURE , Angiotensin-Converting Enzyme Inhibitors , Type 2 diabetes , GLOMERULAR-FILTRATION-RATE , DOUBLE-BLIND , chemistry.chemical_compound , Fumarates , cardiovascular disease , Renin , Treatment Failure , Settore MED/49 - Scienze Tecniche Dietetiche Applicate , 610 Medicine & health , diabetes , Medicine (all) , Hazard ratio , aliskiren , diabete , trial clinico , Liter , General Medicine , Middle Aged , hypertension , Cardiovascular Diseases , Combination , HEART-FAILURE , Drug Therapy, Combination , Female , Kidney Diseases , type 2 diabetes , medicine.symptom , Type 2 , medicine.medical_specialty , Patient Dropouts , Urology , Hypokalemia , Aliskiren , chronic kidney disease , Placebo , Angiotensin Receptor Antagonists , LEFT-VENTRICULAR DYSFUNCTION , Drug Therapy , Double-Blind Method , Diabetes Mellitus , medicine , Humans , CONVERTING-ENZYME INHIBITORS , Antihypertensive Agents , Aged , Amides , Diabetes Mellitus, Type 2 , Follow-Up Studies , business.industry , medicine.disease , Confidence interval , Surgery , Blood pressure , MYOCARDIAL-INFARCTION , chemistry , SYSTOLIC DYSFUNCTION , FOLLOW-UP , business
الوصف:
BACKGROUND This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both. METHODS In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level. RESULTS The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P = 0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, = 6 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P CONCLUSIONS The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful. (Funded by Novartis; ALTITUDE ClinicalTrials.gov number, NCT00549757.)
وصف الملف:
application/pdf
اللغة:
English
تدمد:
0028-4793
DOI:
10.7892/boris.15598
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5677047544fe7663fe50b57da467abbcTest
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....5677047544fe7663fe50b57da467abbc
قاعدة البيانات:
OpenAIRE
