التفاصيل البيبلوغرافية
| العنوان: |
The Role of Targeted Agents in Preoperative Chemoradiation for Rectal Cancer. |
| المؤلفون: |
Wadlow, Raymond C.1, Ryan, David P.1 dpryan@partners.org |
| المصدر: |
Cancer (0008543X). 8/1/2010, Vol. 116 Issue 15, p3537-3548. 12p. |
| مصطلحات موضوعية: |
*FLUOROURACIL, *RECTAL cancer treatment, *PREOPERATIVE care, *BIOMARKERS, *OXALIPLATIN, *DRUG therapy, *RADIOTHERAPY, *THERAPEUTICS |
| مصطلحات جغرافية: |
UNITED States |
| مستخلص: |
The article discusses a study on the benefit of preoperative radiotherapy combined with infusional 5-fluorouracil (FU) followed by total mesorectal excision (TME) in treating patients with T3 or lymph node-positive rectal cancer in the U.S. Some of the novel agents used for the preoperative chemoradiation include Capecitabine, Oxaliplatin and Irinotecan. The study suggests that adding newer cytotoxic agents to preoperative fluoro-pyrimidine-based chemoradiation in patients with locally advanced rectal may enhance pathologic response rates. |
| قاعدة البيانات: |
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