دورية أكاديمية
The Amot/integrin protein complex transmits mechanical forces required for vascular expansion
العنوان: | The Amot/integrin protein complex transmits mechanical forces required for vascular expansion |
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المؤلفون: | Zhang Y., Kameishi S., Barutello G., Zheng Y., Tobin N. P., Nicosia J., Hennig K., Chiu D. K. -C., Balland M., Barker T. H., Cavallo F., Holmgren L. |
المساهمون: | Zhang Y., Kameishi S., Barutello G., Zheng Y., Tobin N.P., Nicosia J., Hennig K., Chiu D.K.-C., Balland M., Barker T.H., Cavallo F., Holmgren L. |
سنة النشر: | 2021 |
المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
مصطلحات موضوعية: | adhesome, angiogenesi, endothelial, force, integrin, mechanotransduction, migration, talin, tumor, vascular, Angiomotin, Animal, Cell Membrane, Cell Movement, Cytoskeleton, Endothelium, Fibronectin, Mice, Transgenic, Neovascularization, Physiologic, Plasma Substitute, Pseudopodia |
الوصف: | Vascular development is a complex multistep process involving the coordination of cellular functions such as migration, proliferation, and differentiation. How mechanical forces generated by cells and transmission of these physical forces control vascular development is poorly understood. Using an endothelial-specific genetic model in mice, we show that deletion of the scaffold protein Angiomotin (Amot) inhibits migration and expansion of the physiological and pathological vascular network. We further show that Amot is required for tip cell migration and the extension of cellular filopodia. Exploiting in vivo and in vitro molecular approaches, we show that Amot binds Talin and is essential for relaying forces between fibronectin and the cytoskeleton. Finally, we provide evidence that Amot is an important component of the endothelial integrin adhesome and propose that Amot integrates spatial cues from the extracellular matrix to form a functional vascular network. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34433061; info:eu-repo/semantics/altIdentifier/wos/WOS:000688508300051; volume:36; issue:8; firstpage:109616; lastpage:109651; numberofpages:36; journal:CELL REPORTS; http://hdl.handle.net/2318/1849491Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85113398825 |
DOI: | 10.1016/j.celrep.2021.109616 |
الإتاحة: | https://doi.org/10.1016/j.celrep.2021.109616Test http://hdl.handle.net/2318/1849491Test |
حقوق: | info:eu-repo/semantics/openAccess |
رقم الانضمام: | edsbas.4DB134B6 |
قاعدة البيانات: | BASE |
DOI: | 10.1016/j.celrep.2021.109616 |
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