Transformation of a cold to hot tumor and a durable response to immunotherapy in a patient with non-small cell lung cancer after chemoradiotherapy: a case report
| العنوان: | Transformation of a cold to hot tumor and a durable response to immunotherapy in a patient with non-small cell lung cancer after chemoradiotherapy: a case report |
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| المؤلفون: | Biao Wu, Longfeng Zhang, Qian Miao, Xiaobin Zheng, Gen Lin, Kan Jiang |
| المصدر: | Annals of Palliative Medicine. 10:4982-4986 |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Population, non-small cell lung cancer (NSCLC), B7-H1 Antigen, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Internal medicine, Tumor Microenvironment, medicine, Humans, Lung cancer, education, Advanced and Specialized Nursing, Tumor microenvironment, education.field_of_study, business.industry, Combination chemotherapy, Chemoradiotherapy, Immunotherapy, Middle Aged, medicine.disease, Radiation therapy, 030104 developmental biology, Anesthesiology and Pain Medicine, 030220 oncology & carcinogenesis, Mutation, business |
| الوصف: | Immune checkpoint inhibitors (ICIs) have become an important milestone in the treatment of non-small cell lung cancer (NSCLC). High expression of protein ligand 1 (PD-L1) and tumor mutation burden (TMB) can help to select the dominant population for immunotherapy, but the expression of PD-L1 does not seem to be unchanged. A 61-year-old man with adenocarcinoma of the lung experienced postoperative recurrence. PD-L1 expression was negative before recurrence, and TMB was stable by next-generation sequencing (NGS) test. However, after radiotherapy and chemotherapy, PD-L1 positive expression was found in a re-biopsy specimen, and NGS detection indicated the loss of immune negative predictive genes. The patient achieved a durable response to a posterior-line immunotherapy combined chemotherapy. The tumor microenvironment maybe changed after chemoradiotherapy, which provides an opportunity for patients to benefit from immunotherapy. The use of NGS in dynamic detection and PD-L1 expression may help monitor this change in the tumor microenvironment, the transition from cold to hot tumor. This case maybe provides new clinical evidence that a non-immuno-dominant population in the initial state can be converted to a population with the benefit of immunotherapy after chemoradiotherapy. However, patients who are initially unsuitable for immunotherapy may still need to undergo combined immunotherapy to achieve a clinical benefit. |
| تدمد: | 2224-5839 2224-5820 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa0135a87fb293551dfe4a6e4aa210eTest https://doi.org/10.21037/apm-21-761Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2aa0135a87fb293551dfe4a6e4aa210e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22245839 22245820 |
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