Experimental Combination Chemotherapy: Intracarotid versus Intravenous Administration of Aziridinylbenzoquinone, BCNU, and Cisplatin in Dogs
| العنوان: | Experimental Combination Chemotherapy: Intracarotid versus Intravenous Administration of Aziridinylbenzoquinone, BCNU, and Cisplatin in Dogs |
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| المؤلفون: | L. C. Stephens, Sidney Wallace, Kenneth C. Wright, Lynn G. Feun, Niramol Savaraj |
| المصدر: | Chemotherapy. 33:437-444 |
| بيانات النشر: | S. Karger AG, 1987. |
| سنة النشر: | 1987 |
| مصطلحات موضوعية: | Lung Diseases, Male, Aziridines, Drug Evaluation, Preclinical, Antineoplastic Agents, Pharmacology, Route of administration, Dogs, Animal model, Antineoplastic Combined Chemotherapy Protocols, Drug Discovery, Benzoquinones, Animals, Infusions, Intra-Arterial, Medicine, Pharmacology (medical), Infusions, Intravenous, Lymphatic Diseases, Cisplatin, Carmustine, Diaziquone, business.industry, Combination chemotherapy, General Medicine, Carotid Arteries, Infectious Diseases, Oncology, Anesthesia, Toxicity, Female, Chemical and Drug Induced Liver Injury, business, medicine.drug |
| الوصف: | Sixteen adult beagles (10-12 kg) were used to evaluate combinations of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ, aziridinylbenzoquinone), 1,3-bis-2-chloroethyl-1-nitrosourea (BCNU, carmustine), and cis-dichlorodiammineplatinum(II) (CDDP, cisplatin) administered by intravenous or intracarotid infusion. Moderate to severe systemic toxicities resulted from all drug infusions, but no histopathologic changes were found in the central nervous system (CNS) of any of the dogs. Results indicated that the toxicities were not dependent on the route of administration or the recipient's gender, and they were reversible in most cases with intravenous supportive therapy. Cisplatin seemed to have an additive effect when administered in combination with AZQ and/or BCNU. |
| تدمد: | 1421-9794 0009-3157 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bdb1e8ca71c092467b46b5eae975cfTest https://doi.org/10.1159/000238532Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b1bdb1e8ca71c092467b46b5eae975cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219794 00093157 |
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