Treatment of Men for 'Low Testosterone': A Systematic Review
| العنوان: | Treatment of Men for 'Low Testosterone': A Systematic Review |
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| المؤلفون: | Alycia Hogenmiller, Alessandra I. Hirsch, Sean McGarvey, Anthony R. Scialli, Bugra Tugertimur, Samantha Huo, Adriane Fugh-Berman, Elizabeth Hill |
| المصدر: | PLoS ONE PLoS ONE, Vol 11, Iss 9, p e0162480 (2016) |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Physiology, lcsh:Medicine, Walking, 030204 cardiovascular system & hematology, Biochemistry, law.invention, Fats, 0302 clinical medicine, Randomized controlled trial, law, Medicine and Health Sciences, Testosterone, Biomechanics, Lipid Hormones, 030212 general & internal medicine, lcsh:Science, Musculoskeletal System, Wasting, Cognitive Impairment, Multidisciplinary, Depression, Cognitive Neurology, Muscle Analysis, Lipids, Cholesterol, Bioassays and Physiological Analysis, Neurology, Androgens, Legs, Anatomy, medicine.symptom, Research Article, medicine.medical_specialty, Cognitive Neuroscience, Research and Analysis Methods, Placebo, 03 medical and health sciences, Internal medicine, Mental Health and Psychiatry, medicine, Libido, Mood Disorders, Biological Locomotion, business.industry, lcsh:R, Limbs (Anatomy), Biology and Life Sciences, Testosterone (patch), medicine.disease, Hormones, Mood, Erectile dysfunction, Physical therapy, Cognitive Science, lcsh:Q, Sexual function, business, Neuroscience |
| الوصف: | Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of "low testosterone" (low-T) for cardiovascular health, sexual function, muscle weakness or wasting, mood and behavior, and cognition. We performed a systematic review of 156 eligible randomized controlled trials in which testosterone was compared to placebo for one or more of these conditions. We included studies in bibliographic databases between January 1, 1950 and April 9, 2016, and excluded studies involving bodybuilding, contraceptive effectiveness, or treatment of any condition in women or children. Studies with multiple relevant endpoints were included in all relevant tables. Testosterone supplementation did not show consistent benefit for cardiovascular risk, sexual function, mood and behavior, or cognition. Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo. Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido. Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function. Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality, psychological well-being, or mood. The prescription of testosterone supplementation for low-T for cardiovascular health, sexual function, physical function, mood, or cognitive function is without support from randomized clinical trials. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b435faa6704bd7bd4cc7a3f1c28f86cTest https://doi.org/10.1371/journal.pone.0162480Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b435faa6704bd7bd4cc7a3f1c28f86c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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