دورية أكاديمية
Drug-induced endocrinopathies and diabetes: a combo-endocrinology overview
| العنوان: | Drug-induced endocrinopathies and diabetes: a combo-endocrinology overview |
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| المؤلفون: | Diamanti-Kandarakis, E, Duntas, L, Kanakis, GA, Kandaraki, E, Karavitaki, N, Kassi, E, Livadas, S, Mastorakos, G, Migdalis, I, Miras, AD, Nader, S, Papalou, O, Poladian, R, Popovic, V, Rachon, D, Tigas, S, Tsigos, C, Tsilchorozidou, T, Tzotzas, T, Bargiota, A, Pfeifer, M |
| المصدر: | R105 ; R73 |
| بيانات النشر: | BioScientifica |
| سنة النشر: | 2019 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, ANDROGEN-DEPRIVATION THERAPY, GLUCOCORTICOID-INDUCED OSTEOPOROSIS, IMMUNE CHECKPOINT BLOCKADE, PROSTATE-CANCER SURVIVORS, POLYCYSTIC-OVARY-SYNDROME, VITAMIN-D DEFICIENCY, HIV-INFECTED ADULTS, POSTMENOPAUSAL WOMEN, WEIGHT-GAIN, NANDROLONE DECANOATE, Animals, Diabetes Mellitus, Endocrine System, Endocrine System Diseases, Endocrinology, Humans, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine |
| الوصف: | In the currently overwhelming era of polypharmacy, the balance of the dynamic and delicate endocrine system can easily be disturbed by interfering pharmaceutical agents like medications. Drugs can cause endocrine abnormalities via different mechanisms, including direct alteration of hormone production, changes in the regulation of the feedback axis, on hormonal transport, binding and signaling, as well as similar changes to counter-regulatory hormone systems. Furthermore, drugs can interfere with the hormonal assays, leading to erroneous laboratory results that disorientate clinicians from the right diagnosis. The purpose of this review is to cover a contemporary topic, the drug-induced endocrinopathies, which was presented in the monothematic annual Combo Endo Course 2018. This challenging part of endocrinology is constantly expanding particularly during the last decade, with the new oncological therapeutic agents, targeting novel molecular pathways in the process of malignancies. In this new context of drug-induced endocrine disease, clinicians should be aware that drugs can cause endocrine abnormalities via different mechanisms and mimic a variety of clinical scenarios. Therefore, it is extremely important for clinicians not only to promptly recognize drug-induced hormonal and metabolic abnormalities, but also to address the therapeutic issues for timely intervention. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0804-4643 |
| العلاقة: | European Journal of Endocrinology; http://hdl.handle.net/10044/1/72481Test; https://doi.org/10.1530/EJE-19-0154Test |
| DOI: | 10.1530/EJE-19-0154 |
| الإتاحة: | https://doi.org/10.1530/EJE-19-0154Test http://hdl.handle.net/10044/1/72481Test |
| حقوق: | © 2019 European Society of Endocrinology 2019 |
| رقم الانضمام: | edsbas.B96E40AF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 08044643 |
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| DOI: | 10.1530/EJE-19-0154 |