Role of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Androgen-Mediated Cell Viability in Prostate Cancer Cells
| العنوان: | Role of 20-Hydroxyeicosatetraenoic Acid (20-HETE) in Androgen-Mediated Cell Viability in Prostate Cancer Cells |
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| المؤلفون: | Cecilia Colombero, Paula Alejandra Sacca, Susana Nowicki, Daniela L. Papademetrio, Elida Alvarez, Eduardo Mormandi |
| المصدر: | Hormones and Cancer. 8:243-256 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Cell Survival, Endocrinology, Diabetes and Metabolism, Apoptosis, Biology, PROSTATE CANCER, Ciencias Biológicas, 03 medical and health sciences, Endocrinology, Cell Line, Tumor, Internal medicine, Hydroxyeicosatetraenoic Acids, LNCaP, medicine, Humans, Cytochrome P450 Family 4, Viability assay, Receptor, Cell Proliferation, Endocrine and Autonomic Systems, ANDROGEN RECEPTOR, Prostatic Neoplasms, Dihydrotestosterone, Bioquímica y Biología Molecular, LNCaP CELLS, Molecular biology, APOPTOSIS, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Receptors, Androgen, Cell culture, Cancer cell, Androgens, CYP4F2, 20-HYDROXYEICOSATETRAENOIC ACID, CIENCIAS NATURALES Y EXACTAS, Intracellular, medicine.drug |
| الوصف: | 20-Hydroxyeicosatetraenoic acid (20-HETE) is generated intracellularly through the ω-hydroxylation of arachidonic acid by the cytochrome P450 (in humans, CYP4A11 and CYP4F2). 20-HETE induces mitogenic responses in different cancer cells. The aim of this study was to analyze how 20-HETE impacts cell survival, proliferation, and apoptosis in prostate cancer cells. Incubation of the human androgen-sensitive cells (LNCaP) with 1?10 μM HET0016 (a selective inhibitor of 20-HETE synthesis) reduced cell viability by 49*?64%* (*p |
| وصف الملف: | application/pdf |
| تدمد: | 1868-8500 1868-8497 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cc0de6e4cded2804c91f4958b3ec3bTest https://doi.org/10.1007/s12672-017-0299-0Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....a9cc0de6e4cded2804c91f4958b3ec3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18688500 18688497 |
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