دورية أكاديمية
Chemotherapy management for unfit patients with metastatic castration-resistant prostate cancer
| العنوان: | Chemotherapy management for unfit patients with metastatic castration-resistant prostate cancer |
|---|---|
| المؤلفون: | Anido Herranz, Urbano, Fernández Nuñez, Natalia, Afonso-Afonso, J., Santome-Couto, L., Medina-Colmenero, A., Fernandez-Calvo, O., Lazaro-Quintela, M., Vázquez Estévez, Sergio |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Humans, Karnofsky Performance Status, Prostatic Neoplasms, Physical Fitness, Aged, Antineoplastic Combined Chemotherapy Protocols, Algorithms, protocolos de quimioterapia antineoplásica combinada, anciano, neoplasias de la próstata, algoritmos, aptitud física, grado de actividad de Karnofsky, humanos, CHUS, HULA |
| الوصف: | Administration of chemotherapy in prostate cancer depends on patient fitness. In unfit patients, physiological impairment determines the optimum treatment. Although no consensus on assessing patient fitness currently exists, this article proposes an algorithm combining the available information for administering chemotherapy, and in particular docetaxel, in unfit patients. It was constructed by reviewing factors that can influence treatment, such as performance status, taxane-related comorbidities and nutritional status. Geriatric scales for prostate cancer patients and alternative treatment regimens for this population are also reviewed. In summary, patients require overall assessment to optimise treatment. Use of docetaxel should be restricted in unfit patients, and other options must be evaluated, because of high toxicity and low efficacy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1699-048X |
| العلاقة: | https://link.springer.com/content/pdf/10.1007/s12094-018-1928-y.pdfTest; https://www.ncbi.nlm.nih.gov/pubmed/30051212Test; http://hdl.handle.net/20.500.11940/16076Test; 34974 |
| DOI: | 10.1007/s12094-018-1928-y |
| الإتاحة: | https://doi.org/20.500.11940/16076Test https://doi.org/10.1007/s12094-018-1928-yTest https://hdl.handle.net/20.500.11940/16076Test https://www.ncbi.nlm.nih.gov/pubmed/30051212Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.1542655D |
| قاعدة البيانات: | BASE |
| تدمد: | 1699048X |
|---|---|
| DOI: | 10.1007/s12094-018-1928-y |