المؤلفون: Scarini, João Figueira, de Lima-Souza, Reydson Alcides, Lavareze, Luccas, Emerick, Carolina, Miyaok, Rafaella Dini, Kinasz, Letícia Raysa Schiavon, Maunsell, Rebecca, Egal, Erika Said Abu, Altemani, Albina, Mariano, Fernanda Viviane

المساهمون: Fundação de Amparo à Pesquisa do Estado de São Paulo

المصدر: International Journal of Surgical Pathology ; volume 31, issue 6, page 1122-1125 ; ISSN 1066-8969 1940-2465

مصطلحات موضوعية: Pathology and Forensic Medicine, Surgery, Anatomy

الوصف: We present a 21-day-old female child presenting with a large oral epithelialized tumor implanted at the rhinopharynx and ethmoid plate through a cleft palate, associated with feeding and respiratory difficulties. The histopathological exam showed mature central adipose tissue, hair follicles, sebaceous glands, and neurovascular structures, lined by keratinized stratified squamous epithelium. Proliferative cartilaginous, glandular, lymphatic, bony, and immature myxoid tissue was seen at the posterior region and insertion. Despite the characterization of the tumor as a teratoma containing structures derived from the three embryonic leaflets, the anterior portion presented a microscopic bigeminal pattern fully compatible with hairy polyp.

الإتاحة: https://doi.org/10.1177/10668969221129889Test

المؤلفون: Mariano, Fernanda Viviane, Gondak, Rogério Oliveira, Scarini, João Figueira, da Silva, Eduardo Caetano Albino, Caravina, Gisele, Scapulatempo-Neto, Cristovam, Almeida, Oslei Paes, Altemani, Albina, Mosqueda Taylor, Adalberto

المساهمون: fundação de amparo à pesquisa do estado de são paulo

المصدر: International Journal of Surgical Pathology ; volume 28, issue 2, page 181-187 ; ISSN 1066-8969 1940-2465

مصطلحات موضوعية: Pathology and Forensic Medicine, Surgery, Anatomy

الوصف: Dentinoid has been mentioned as a frequent component in several types of benign odontogenic tumors; however, there are some other very rare dentinoid-producing odontogenic tumors that have been described, which are not recognized in the current World Health Organization Histological Classification of Odontogenic Tumours. In this context, we report an unusual malignant odontogenic tumor containing dentinoid located in the left maxilla of a 41-year-old man. The lesion was initially diagnosed and treated as a cemento-ossifying fibroma. After 7 years, a tumor was noted at the same location and was diagnosed as pleomorphic adenoma. The patient developed a new lesion 2 years later. Histological features included an epithelial proliferation of basaloid and clear cells, some with peripheral palisading, which were scattered both in a fibrous stroma and within an amorphous eosinophilic dentinoid product. Because of doubts about the first 2 diagnoses and the current situation, all histopathological slides were reviewed in our service as a consultation case, and the findings were consistent with the diagnosis of an odontogenic carcinoma with dentinoid. Immunohistochemical analysis was performed and an ultrastructural study by scanning electronic microscopy and energy-dispersive X-ray microanalysis was made to characterize dentinoid material. After 1 year of follow-up, the patient is alive and free of the disease. This case highlights the wide variability regarding cytological evidence of malignancy, and adds a new case of odontogenic carcinoma with dentinoid, which represents a distinct entity with locally aggressive behavior and should be considered be included in a future World Health Organization Histological Classification of Tumours.

الإتاحة: https://doi.org/10.1177/1066896919871662Test