Bilirubin Measurement for Neonates: Comparison of 9 Frequently Used Methods
| العنوان: | Bilirubin Measurement for Neonates: Comparison of 9 Frequently Used Methods |
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| المؤلفون: | Matthias Nauck, Ada Goerlach-Graw, Cornelia Müller, Ingrid Kadow, Boris Rolinski, H. Küster, Markus Roser, Karina Grohmann |
| المصدر: | Pediatrics. 117:1174-1183 |
| بيانات النشر: | American Academy of Pediatrics (AAP), 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, Analyte, Pediatrics, medicine.medical_specialty, Bilirubin, Sensitivity and Specificity, chemistry.chemical_compound, Neonatal Screening, Predictive Value of Tests, medicine, Humans, Skin, Chromatography, business.industry, Infant, Newborn, Skin test, Jaundice, medicine.disease, Bilirubin measurement, ROC Curve, chemistry, Pediatrics, Perinatology and Child Health, Kernicterus, Female, Hyperbilirubinemia, Neonatal, medicine.symptom, Bilirubin levels, business, Blood sampling |
| الوصف: | OBJECTIVE. High blood concentrations of bilirubin are toxic to the brain and may cause kernicterus. Therefore, determination of bilirubin levels is performed for many newborns, and several different methods are available. We compared 9 frequently used methods for bilirubin determination among newborns under routine conditions, to define their sequence of use. METHODS. In a prospective study, bilirubin concentrations were determined with 9 different methods, ie, 3 skin test devices, 3 nonchemical photometric devices (including 2 blood gas analyzers), and 3 laboratory analyzers. RESULTS. A total of 124 samples were obtained. All 3 laboratory methods showed very strong correlations with each other, and their means were used as comparison values. To these comparison values, the skin test devices had correlation coefficients between 0.961 and 0.966, and the nonchemical photometric devices between 0.980 and 0.994. Bland-Altman plots demonstrated good agreement with the comparison values for all nonchemical photometric devices. All skin test devices and 1 nonchemical photometric device underestimated bilirubin levels, particularly at high concentrations. CONCLUSIONS. In the routine care of newborns, the first method for bilirubin testing should be a skin test. If the skin test result exceeds 200 μmol/L and other analytes are to be determined with a nonchemical photometric device, then bilirubin can be included in this analysis and the result trusted up to 250 μmol/L. If the skin test result exceeds 200 μmol/L and only bilirubin concentrations are needed, then a standard laboratory method is the first choice, to avoid repeated blood sampling. Bilirubin concentrations from nonchemical photometric devices that exceed 250 μmol/L should be confirmed with standard laboratory methods. |
| تدمد: | 1098-4275 0031-4005 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cdfe24aee5e1169ecb437e3b11008cTest https://doi.org/10.1542/peds.2005-0590Test |
| رقم الانضمام: | edsair.doi.dedup.....f5cdfe24aee5e1169ecb437e3b11008c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10984275 00314005 |
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