The Effect of Metformin on Adipose Tissue Metabolism and Peripheral Blood Flow in Subjects With NIDDM
| العنوان: | The Effect of Metformin on Adipose Tissue Metabolism and Peripheral Blood Flow in Subjects With NIDDM |
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| المؤلفون: | P. N. Lönnroth, O. K. Andersson, H. S. Gudbjörnsdottir, Per-Anders Jansson |
| المصدر: | Diabetes Care. 19:160-164 |
| بيانات النشر: | American Diabetes Association, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Blood Glucose, Glycerol, Male, medicine.medical_specialty, Microdialysis, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Adipose tissue, Body Mass Index, Reference Values, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Muscle, Skeletal, Advanced and Specialized Nursing, Analysis of Variance, Glucose tolerance test, medicine.diagnostic_test, business.industry, Blood flow, Glucose Tolerance Test, Middle Aged, medicine.disease, Sulfonylurea, Metformin, Endocrinology, Adipose Tissue, Diabetes Mellitus, Type 2, Regional Blood Flow, Metabolic control analysis, Body Composition, Lactates, business, medicine.drug |
| الوصف: | OBJECTIVE To examine the effect of metformin on net lactate and glycerol release in NIDDM subjects, we used abdominal subcutaneous microdialysis combined with 133Xe clearance. Skeletal muscle blood flow (MBF) was assessed simultaneously both before and after metformin treatment. RESEARCH DESIGN AND METHODS Nine male patients with NIDDM (age 53 ± 2 years [mean ± SE]; BMI 30.2 ± 1.4 kg/m2; body fat 23.0 ± 2.6 kg; diabetes duration 4.6 ± 1.5 years; six of nine receiving sulfonylurea treatment) were recruited into an open study. They were studied after an overnight fast, both before and after 1 week of additional treatment with 500 mg metformin three times daily. Nine weight- and age-matched nondiabetic subjects served as a control group. RESULTS Postabsorptive net subcutaneous lactate release increased (149 ± 50 vs. 475 ± 127 nmol · 100 g1 · min−1, P < 0.05) whereas plasma lactate was unchanged after metformin treatment in the NIDDM patients. The net decrease of glycerol release 90 min after an oral glucose tolerance test was more pronounced (110 ± 30 vs. 199 ± 20 nmol · 100 g−1 · min−1, P < 0.05) after metformin treatment. Both adipose tissue blood flow (ATBF) (1.5 ± 0.1 vs. 2.3 ± 0.2 ml · 100 g−1 · min−1, P < 0.01) and MBF (3.2 ± 0.4 vs. 4.2 ± 0.5 ml · 100 ml−1 · min−1, P < 0.05) increased after metformin treatment. CONCLUSIONS In this open study, postabsorptive net lactate release in abdominal subcutaneous adipose tissue was clearly increased in NIDDM patients after metformin treatment. Basal ATBF as well as MBF was improved after metformin treatment. Whether this reflects enhanced metabolic control or is a drug-specific effect remains to be established. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e164b2f1c4148a4c4d562a5ae09cbdc6Test https://doi.org/10.2337/diacare.19.2.160Test |
| رقم الانضمام: | edsair.doi.dedup.....e164b2f1c4148a4c4d562a5ae09cbdc6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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