التفاصيل البيبلوغرافية
| العنوان: |
Treatment of advanced HIV disease in antiretroviral-naïve HIV-1-infected patients receiving once-daily atazanavir/ritonavir or twice-daily lopinavir/ritonavir, each in combination with tenofovir disoproxil fumarate and emtricitabine. |
| المؤلفون: |
Uy, Jonathan, Yang, Rong, Wirtz, Victoria, Sheppard, Louise, Farajallah, Awny, McGrath, Donnie |
| المصدر: |
AIDS Care; Nov2011, Vol. 23 Issue 11, p1500-1504, 5p |
| مصطلحات موضوعية: |
ANTIVIRAL agents, ANALYSIS of variance, BLOOD cell count, COMBINATION drug therapy, CONFIDENCE intervals, HIV infections, RESEARCH funding, T cells |
| مستخلص: |
Current guidelines for HIV therapy recommend initiating treatment at a CD4 cell count of 500 cells/mm3. However, a large proportion of patients with HIV infection begin antiretroviral treatment at a more advanced stage. In the CASTLE study, patients with the most advanced HIV disease (CD4 cell count <50 cells/mm3) showed that 78% (45/58) vs. 58% (28/48) of the patients achieved HIV RNA <50 copies/mL in the intent-to-treat analysis at week 96 for atazanavir/ritonavir and lopinavir/ritonavir, respectively. This current sub-analysis of the CASTLE study describes demographics, virologic failure, discontinuations, safety, tolerability, immunologic response, and clinical outcomes for the following baseline strata: CD4 cell count (cells/mm3) <50, 50 to <100, 100 to <200, and ≥200 and HIV RNA (copies/mL) <100,000, 100,000 to <500,000, and ≥500,000. In the lowest CD4 cell count stratum (<50 cells/mm3), the proportion of discontinuations was 2-fold greater for the lopinavir/ritonavir arm (33%) than for the atazanavir/ritonavir arm (16%) with a similar rate of virologic failure between the two groups. Also in this CD4 cell count stratum, grades 2–4 treatment-related adverse events occurred in 25% in the atazanavir/ritonavir group and in 43% of lopinavir/ritonavir group, and the rate was also higher than in the higher CD4 cell count strata within the lopinavir/ritonavir treatment group (range: 29–34%). Grades 2–4 treatment-related diarrhea and nausea occurred in more patients receiving lopinavir/ritonavir than atazanavir/ritonavir in all strata. The atazanavir/ritonavir group had more grades 2–4 treatment-related jaundice than in the lopinavir/ritonavir group. These results highlight the importance of tolerability of antiretroviral therapy (ART) in the patients at greatest risk of morbidity and mortality when using regimens of similar potency. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
