Endurance Performance: Genes or Gene Combinations?
| العنوان: | Endurance Performance: Genes or Gene Combinations? |
|---|---|
| المؤلفون: | Catalina Santiago, Félix Gómez-Gallego, Marta Gonzalez-Freire, Carlos A. Muniesa, Alejandro Lucia, M. Fernández del Valle, Carl Foster, Margarita Pérez |
| المصدر: | International Journal of Sports Medicine. 30:66-72 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Genotype, Peptidyl-Dipeptidase A/*Genetics, Ace genotype, Peak power output, Physical Therapy, Sports Therapy and Rehabilitation, Peptidyl-Dipeptidase A, Biology, Fisiología humana, Respiratory compensation, Physical Endurance/*Genetics, Pulmonary Ventilation/Physiology, Atleta, Internal medicine, medicine, Humans, Actinin, Orthopedics and Sports Medicine, Gross efficiency, Gene, Analysis of Variance, Bicycling, Deporte, Respiratory Function Tests, Phenotype, Endocrinology, Physical Endurance, Exercise Test, Physical therapy, Analysis of variance, Pulmonary Ventilation, human activities |
| الوصف: | We assessed the possible association between variants of the genes encoding for the angiotensin-converting enzyme ( ACE) and alpha-actinin-3 ( ACTN3) (both individually and combined) and several endurance phenotypic traits, e.g., peak power output (PPO), ventilatory (VT) and respiratory compensation threshold (RCT), among others, in professional road cyclists and sedentary controls (n = 46 each). We applied an ANCOVA test using the aforementioned phenotype traits as dependent variables, ACE and/or ACTN3 genotype as the fixed (independent) factor and age and body mass as covariates. We only found a significant genotype effect with no concomitant covariate effect for ACTN3, with cyclists who were not alpha-actinin-3 deficient (RR + RX genotypes) having higher PPO and VT values than their XX counterparts (mean [SEM]: 7.4 (0.1) vs. 7.1 (0.1) W/kg, p = 0.035; and 4.5 (0.1) vs. 4.3 (0.1) W/kg, p = 0.029, respectively). Cyclists with an "extreme" ACTN3 and ACE genotype combination, i.e., most strength/power oriented (DD + RR/RX), had higher RCT values than those with the "intermediate" combinations (II + RX/RR, p = 0.036; and DD + XX, p = .0004) but similar to those with the most endurance oriented genotype (II + XX). No significant differences (p > 0.05) were found in controls. In summary, in world-class cyclists, we only found an association between ACTN3 genotypes and VT and PPO, and between ACTN3/ACE genotype combinations and RCT. 1.589 JCR (2009) Q2, 27/73 Sport sciences UEM |
| تدمد: | 1439-3964 0172-4622 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce293dfc17acd560fff18570bee4e91Test https://doi.org/10.1055/s-2008-1038677Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8ce293dfc17acd560fff18570bee4e91 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14393964 01724622 |
|---|