Topical cannabis‐based medicines – A novel paradigm and treatment for non‐uremic calciphylaxis leg ulcers: An open label trial
| العنوان: | Topical cannabis‐based medicines – A novel paradigm and treatment for non‐uremic calciphylaxis leg ulcers: An open label trial |
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| المؤلفون: | Francesco Gabriele Tatangelo Fazzari, Vincent Maida, Lydia Zomparelli, Runjie Bill Shi |
| المصدر: | International Wound Journal |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | topical cannabis‐based medicines, medicine.medical_specialty, Analgesic, Dermatology, wound closure, wound‐related pain, Cohort Studies, non‐uremic Calciphylaxis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, endocannabinoid system, Aged, Cannabis, Analgesics, Wound Healing, Calciphylaxis, integumentary system, biology, business.industry, Leg Ulcer, Integumentary system, Original Articles, biology.organism_classification, medicine.disease, Cohort, Original Article, Female, Surgery, Wound closure, Open label, business, Cohort study |
| الوصف: | Non‐Uremic Calciphylaxis (NUC) is a rare condition that often manifests as intractable and painful integumentary wounds, afflicting patients with a high burden of co‐morbidity. The Endocannabinoid System (ECS) is a ubiquitous signalling system that is theorised to be dysregulated within wound beds and associated peri‐wound tissues. Preclinical research has shown that the dominant chemical classes derived from the cannabis plant, cannabinoids, terpenes, and flavonoids, interact with the integumentary ECS to promote wound closure and analgesia. This is a prospective open label cohort study involving two elderly Caucasian females with recalcitrant NUC leg ulcers of greater than 6 months duration. Topical Cannabis‐Based Medicines (TCBM) composed of cannabinoids, terpenes, and flavonoids were applied daily to both the wound bed and peri‐wound tissues until complete wound closure was achieved. Wounds were photographed regularly, and the digital images were subjected to planimetric analysis to objectively quantify the degree of granulation and epithelization. Analgesic utilisation, as a surrogate/proxy for pain scores, was also tracked. The cohort had a mean M3 multimorbidity index score of 3.31. Complete wound closure was achieved in a mean of 76.3 days. Additionally, no analgesics were required after a mean of 63 days. The treatments were well tolerated with no adverse reactions. The positive results demonstrated in very challenging wounds such as NUC, among highly complex patients, suggest that TCBM may have an even broader role within integumentary and wound management. This treatment paradigm warrants being trialled in other wound types and classes, and ultimately should be subjected to randomised controlled trials. |
| تدمد: | 1742-481X 1742-4801 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ac3a053628ba887e02d535981decffTest https://doi.org/10.1111/iwj.13484Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....98ac3a053628ba887e02d535981decff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1742481X 17424801 |
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