دورية أكاديمية
A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers
| العنوان: | A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers |
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| المؤلفون: | Zhang, M. (Ming), Ferrari, R. (Roberto), Tartaglia, M.C. (Maria Carmela), Keith, J. (Julia), Surace, E.I. (Ezequiel I.), Wolf, U. (Uri), Sato, C. (Christine), Grinberg, M. (Mark), Liang, Y. (Yan), Xi, Z. (Zhengrui), Dupont, K. (Kyle), McGoldrick, P. (Philip), Weichert, A. (Anna), McKeever, P.M. (Paul M.), Schneider, R. (Raphael), McCorkindale, M.D. (Michael D.), Manzoni, C. (Claudia), Rademakers, S. (Suzanne), Graff-Radford, N.R. (Neill), Dickson, D. (Dennis), Parisi, J.E. (Joseph), Boeve, B.F. (Bradley), Petersen, R.C. (Ronald C.), Miller, B.L. (Bruce Lars), Seeley, W.W. (William W.), Swieten, J.C. (John) van, van Rooij, J. (Jeroen), Pijnenburg, Y.A.L. (Yolande), Zee, J. (Jill) van der, Broeckhoven, C. (Christine) van, Le Ber, I. (Isabelle), Deerlin, V.M. (Vivianna), Suh, E. (Eunran), Rohrer, J.D. (Jonathan), Mead, S. (Simon), Graff, C. (Caroline), Öijerstedt, L. (Linn), Pickering-Brown, S. (Stuart), Rollinson, S. (Sara), Rossi, G. (Giacomina), Tagliavini, F. (Fabrizio), Brooks, W.S. (William), Dobson-Stone, C. (Carol), Halliday, G.M. (Glenda Margaret), Hodges, J. (John), Piguet, O. (Olivier), Binetti, G. (Giuliano), Benussi, L. (Luisa), Ghidoni, R. (Roberta), Nacmias, B. (Benedetta), Sorbi, S. (Sandro), Bruni, A.C. (Amalia), Galimberti, D. (Daniela), Scarpini, E. (Elio), Rainero, I. (Innocenzo), Rubino, M. (Maurizio), Clarimon, J. (Jordi), Lleo, A. (Alberto), Ruiz, A. (A.), Hernández, I. (Isabel), Pastor, P. (Pau), Diez-Fairen, M. (Monica), Borroni, B. (Barbara), Pasquier, F. (Florence), Deramecourt, V. (Vincent), Lebouvier, T. (Thibaud), Perneczky, R. (Robert), Diehl-Schmid, J. (Janine), Grafman, J. (Jordan), Huey, E.D. (Edward), Mayeux, R. (Richard), Nalls, M.A. (Michael), Hernandez, D.G. (Dena), Singleton, A. (Andrew), Momeni, P. (Parastoo), Zeng, Z. (Zhen), Hardy, J. (John), Robertson, J. (Janice), Zinman, L. (Lorne), Rogaeva, E. (Ekaterina) |
| المصدر: | Brain: a journal of neurology vol. 141 no. 10, pp. 2895-2907 |
| سنة النشر: | 2018 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | C9orf72, genetic association, age of onset, amyotrophic lateral sclerosis, frontotemporal dementia |
| الوصف: | The G4C2-repeat expansion in C9orf72 is the most common known cause of amyotrophic lateral sclerosis and frontotemporal dementia. The high phenotypic heterogeneity of C9orf72 patients includes a wide range in age of onset, modifiers of which are largely unknown. Age of onset could be influenced by environmental and genetic factors both of which may trigger DNA methylation changes at CpG sites. We tested the hypothesis that age of onset in C9orf72 patients is associated with some common single nucleotide polymorphisms causing a gain or loss of CpG sites and thus resulting in DNA methylation alterations. Combined analyses of epigenetic and genetic data have the advantage of detecting functional variants with reduced likelihood of false negative results due to excessive correction for multiple testing in genome-wide association studies. First, we estimated the association between age of onset in C9orf72 patients (n = 46) and the DNA methylation levels at all 7603 CpG sites available on the 450 k BeadChip that are mapped to common single nucleotide polymorphisms. This was followed by a genetic association study of the discovery (n = 144) and replication (n = 187) C9orf72 cohorts. We found that age of onset was reproducibly associated with polymorphisms within a 124.7 kb linkage disequilibrium b |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/110902Test; urn:hdl:1765/110902 |
| DOI: | 10.1093/brain/awy238 |
| الإتاحة: | https://doi.org/10.1093/brain/awy238Test http://repub.eur.nl/pub/110902Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.84D4D816 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/brain/awy238 |
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