Konformationelle Antikörper fragmente für amyloide Erkrankungen
| العنوان: | Konformationelle Antikörper fragmente für amyloide Erkrankungen |
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| المؤلفون: | Marcus Fändrich, Uwe Horn, Christian Haupt, Dietmar Rudolf Thal |
| المصدر: | BIOspektrum. 20:12-14 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Biochemistry, Amyloid, In vivo, Chemistry, Pharmacology toxicology, Endogeny, Amyloid fibril, Molecular Biology, Antibody fragments, In vitro, Biotechnology |
| الوصف: | Conformational diseases, such as Alzheimer’s or Parkinson’s, are characterized by the misfolding of endogenous polypeptide chains into abnormal amyloid fibril conformations. To better analyze this process and its biological consequences and to generate tools for targeted interference in vitro and in vivo, we have biotechnologically generated a set of antibody fragments that are able to discriminate by binding between different amyloid assembly states. |
| تدمد: | 1868-6249 0947-0867 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::20ef9b267ea824cefa2bcf4e48942694Test https://doi.org/10.1007/s12268-014-0397-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........20ef9b267ea824cefa2bcf4e48942694 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18686249 09470867 |
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