دورية أكاديمية
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy ; Proceedings of the National Academy of Sciences of the United States of America
| العنوان: | Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy ; Proceedings of the National Academy of Sciences of the United States of America |
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| المؤلفون: | Drake, Joshua C., Wilson, Rebecca J., Laker, Rhianna C., Guan, Yuntian, Spaulding, Hannah R., Nichenko, Anna S., Shen, Wenqing, Shang, Huayu, Dorn, Maya, Huang, Kian, Zhang, Mei, Bandara, Aloka B., Brisendine, Matthew H., Kashatus, Jennifer A., Sharma, Poonam R., Young, Alexander, Gautam, Jitendra, Cao, Ruofan, Wallrabe, Horst, Chang, Paul A., Wong, Michael, Desjardins, Eric M., Hawley, Simon A., Christ, George J., Kashatus, David F., Miller, Clint L., Wolf, Matthew J., Periasamy, Ammasi, Steinberg, Gregory R., Hardie, D. Grahame, Yan, Zhen |
| بيانات النشر: | National Academy of Sciences |
| سنة النشر: | 2021 |
| المجموعة: | VTechWorks (VirginiaTech) |
| مصطلحات موضوعية: | mitochondria, AMPK, skeletal muscle, exercise, mitophagy, ACTIVATED PROTEIN-KINASE, SKELETAL-MUSCLE, SUBCELLULAR-DISTRIBUTION, RAT-LIVER, MITOTIMER, RETICULUM, AUTOPHAGY, GENE, SITE, PHOSPHORYLATION, AMP-Activated Protein Kinases, Animals, Energy Metabolism, Humans, Male, Mice, Physical Conditioning, Animal |
| الوصف: | Mitochondria form a complex, interconnected reticulum that is maintained through coordination among biogenesis, dynamic fission, and fusion and mitophagy, which are initiated in response to various cues to maintain energetic homeostasis. These cellular events, which make up mitochondrial quality control, act with remarkable spatial precision, but what governs such spatial specificity is poorly understood. Herein, we demonstrate that specific isoforms of the cellular bioenergetic sensor, 5 AMP-activated protein kinase (AMPK1/ 2/2/1), are localized on the outer mitochondrial membrane, referred to as mitoAMPK, in various tissues in mice and humans. Activation of mitoAMPK varies across the reticulum in response to energetic stress, and inhibition of mitoAMPK activity attenuates exercise-induced mitophagy in skeletal muscle in vivo. Discovery of a mitochondrial pool of AMPK and its local importance for mitochondrial quality control underscores the complexity of sensing cellular energetics in vivo that has implications for targeting mitochondrial energetics for disease treatment. ; Published version |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 10 page(s); application/pdf |
| اللغة: | English |
| تدمد: | 0027-8424 34493662 1091-6490 |
| العلاقة: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000703999300020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1Test; ARTN e2025932118 (Article number); 2025932118 (PII); http://hdl.handle.net/10919/107452Test; https://doi.org/10.1073/pnas.2025932118Test; 118; 37; Bandara, Aloka [0000-0002-2562-1810]; Drake, Joshua [0000-0001-6658-4975] |
| DOI: | 10.1073/pnas.2025932118 |
| الإتاحة: | https://doi.org/10.1073/pnas.2025932118Test http://hdl.handle.net/10919/107452Test |
| حقوق: | Creative Commons Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.61D93E54 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00278424 34493662 10916490 |
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| DOI: | 10.1073/pnas.2025932118 |