دورية أكاديمية
Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice
| العنوان: | Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice |
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| المؤلفون: | van Swelm, Rachel P. L., Laarakkers, Coby M. M., van der Kuur, Ellen C., Morava-Kozicz, Eva, Wevers, Ron A., Augustijn, Kevin D., Touw, Daan J., Sandel, Maro H., Masereeuw, Rosalinde, Russel, Frans G. M. |
| المصدر: | van Swelm , R P L , Laarakkers , C M M , van der Kuur , E C , Morava-Kozicz , E , Wevers , R A , Augustijn , K D , Touw , D J , Sandel , M H , Masereeuw , R & Russel , F G M 2012 , ' Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice ' , PLoS ONE , vol. 7 , no. 11 , e49524 . https://doi.org/10.1371/journal.pone.0049524Test |
| سنة النشر: | 2012 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | acetylsalicylic acid, alanine aminotransferase, alendronic acid, alprazolam, amoxicillin plus clavulanic acid, biological marker, caffeine, calmodulin, carbonate dehydratase III, copper zinc superoxide dismutase, cotrimoxazole, diazepam, dipyridamole, furosemide, ibuprofen, lercanidipine, metacetamol, metoprolol, omeprazole, pantoprazole, paracetamol, adult, aged, alanine aminotransferase blood level, animal experiment, animal model, article, body weight, controlled study, female |
| الوصف: | Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) followed by 24 h urine collection. Doses of ≥275 mg/kg bw APAP resulted in hepatic centrilobular necrosis and significantly elevated plasma alanine aminotransferase (ALT) values (p |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/6a882589-f692-4f57-922d-106799a26757Test |
| DOI: | 10.1371/journal.pone.0049524 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0049524Test https://hdl.handle.net/11370/6a882589-f692-4f57-922d-106799a26757Test https://research.rug.nl/en/publications/6a882589-f692-4f57-922d-106799a26757Test https://pure.rug.nl/ws/files/48884749/Van_Swelm_2012_Identification_of_novel_translation.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CDFB1E16 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0049524 |
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