دورية أكاديمية
Electrophysiological characterization of BmK MI, an alpha-like toxin from Buthus martensi Karsch vernom
| العنوان: | Electrophysiological characterization of BmK MI, an alpha-like toxin from Buthus martensi Karsch vernom |
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| المؤلفون: | Goudet, Cyril, Huys, Isabelle, Clynen, Elke, Schoofs, Liliane, Wang, DC, Waelkens, Etienne, Tytgat, Jan |
| بيانات النشر: | Elsevier on behalf of the Federation of European Biochemical Societies |
| سنة النشر: | 2001 |
| المجموعة: | KU Leuven: Lirias |
| مصطلحات موضوعية: | Animals, Dose-Response Relationship, Drug, Gene Expression, Humans, Insect Proteins, Membrane Potentials, Microinjections, Molecular Sequence Data, Neurotoxins, Oocytes, Patch-Clamp Techniques, RNA, Complementary, Research Support, Non-U.S. Gov't, Scorpion Venoms, Scorpions, Sequence Homology, Amino Acid, Sodium Channel Blockers, Sodium Channels, Xenopus |
| الوصف: | The present study investigates the electrophysiological actions of BmK M1, an alpha-like toxin purified from the venom of the scorpion Buthus martensi Karsch, on voltage-gated Na+ channels. Using the voltage clamp technique, we assessed the BmK M1 activity on the cardiac Na+ channel (hH1) functionally expressed in Xenopus oocytes. The main actions of the toxin are a concentration-dependent slowing of the inactivation process and a hyperpolarizing shift of the steady-state inactivation. This work is the first electrophysiological characterization of BmK M1 on a cloned Na+ channel, demonstrating that this toxin belongs to the class of scorpion alpha-toxins. Our results also show that BmK M1 can be considered as a cardiotoxin. ; status: published |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0014-5793 |
| العلاقة: | FEBS Letters vol:495 issue:1-2 pages:61-65; https://lirias.kuleuven.be/handle/123456789/246820Test; http://linkinghub.elsevier.com/retrieve/pii/S0014-5793Test(01)02365-1; https://lirias.kuleuven.be/bitstream/123456789/246820/3//Goudet+et+al._2001_FEBS+Letters_vol495_p61-65.pdfTest |
| الإتاحة: | https://lirias.kuleuven.be/handle/123456789/246820Test http://linkinghub.elsevier.com/retrieve/pii/S0014-5793Test(01)02365-1 https://lirias.kuleuven.be/bitstream/123456789/246820/3//Goudet+et+al._2001_FEBS+Letters_vol495_p61-65.pdfTest |
| رقم الانضمام: | edsbas.6A69AE3B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00145793 |
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